CAS 2272976-28-8

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-

Description:

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- is a complex organic compound characterized by its multi-cyclic structure, which includes a pyrazolo-pyrimidine core and various functional groups that contribute to its biological activity. The presence of a spirocyclic moiety and multiple nitrogen atoms suggests potential interactions with biological targets, making it of interest in medicinal chemistry. The compound's structure indicates it may exhibit properties such as enzyme inhibition or receptor modulation, which are common in drug candidates. Additionally, the presence of substituents like hydroxy and alkyl groups may influence its solubility, stability, and overall pharmacokinetic profile. As a relatively novel compound, its specific applications and mechanisms of action would require further investigation through experimental studies to elucidate its potential therapeutic uses.

Formula: C₂₈H₃₁N₇O₂

InChI: InChI=1S/C28H31N7O2/c1-5-13-34-25(36)20-15-29-26(32-24(20)35(34)23-8-6-7-22(31-23)27(2,3)37)30-19-9-10-21-18(14-19)16-33(4)17-28(21)11-12-28/h5-10,14-15,37H,1,11-13,16-17H2,2-4H3,(H,29,30,32)

InChI key: JSZFIXAMFNNRKS-UHFFFAOYSA-N

SMILES: CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC5=C(C=C4)C6(CC6)CN(C5)C)O

Synonyms:

• JUN76288
• WEE1-IN-3
• 3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-

WEE1-IN-3

CAS: 2272976-28-8

WEE1-IN-3

Formula: C₂₈H₃₁N₇O₂

Purity: ≥98%

Molecular weight: 497.59

Ref: 54-BUP08074

2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

CAS: 2272976-28-8

Ref: IN-DA01V3LF

WEE1-IN-3

CAS: 2272976-28-8

WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.

Formula: C₂₈H₃₁N₇O₂

Purity: 98.33%

Color and Shape: Solid

Molecular weight: 497.5914

Ref: TM-T8916

WEE1-IN-3

CAS: 2272976-28-8

WEE1-IN-3 is a peptide inhibitor that binds to the ATP-binding pocket of WEE1. The binding site of this peptide is different from that of other inhibitors, such as GSK2606414 and Iressa, which bind to the ATP hydrolysis site. WEE1-IN-3 blocks the activation of WEE1 in response to DNA damage and inhibits cell proliferation by blocking protein synthesis. This peptide is a research tool for studying the role of WEE1 in many cellular processes, including ion channels and cell cycle regulation.

Formula: C₂₈H₃₁N₇O₂

Purity: Min. 95%

Molecular weight: 497.6 g/mol

Ref: 3D-XQD97628