CAS 234772-64-6

CGP77675

Description:

CGP77675, with the CAS number 234772-64-6, is a chemical compound that functions primarily as a selective inhibitor of the protein kinase mTOR (mechanistic target of rapamycin). This compound is notable for its role in research related to cancer and metabolic diseases, as mTOR is a critical regulator of cell growth, proliferation, and survival. CGP77675 exhibits a specific binding affinity for the mTOR kinase domain, which allows it to effectively modulate signaling pathways associated with cellular metabolism and growth. The compound is typically characterized by its molecular structure, which includes specific functional groups that contribute to its biological activity. In laboratory settings, CGP77675 is often utilized in preclinical studies to explore its therapeutic potential and to understand the underlying mechanisms of diseases where mTOR signaling is dysregulated. As with many research chemicals, safety and handling precautions are essential, and its use is generally confined to controlled environments such as research laboratories.

Formula: C₂₆H₂₉N₅O₂

InChI: InChI=1S/C26H29N5O2/c1-33-22-4-2-3-19(15-22)23-16-31(26-24(23)25(27)28-17-29-26)20-7-5-18(6-8-20)9-12-30-13-10-21(32)11-14-30/h2-8,15-17,21,32H,9-14H2,1H3,(H2,27,28,29)

InChI key: WUPXZZWTHIZICK-UHFFFAOYSA-N

SMILES: COC1=CC=CC(=C1)C2=CN(C3=NC=NC(=C23)N)C4=CC=C(C=C4)CCN5CCC(CC5)O

Synonyms:

• 1-(2-{4-[4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl}ethyl)piperidin-4-ol
• CGP77675 >=98% (HPLC)
• CGP77675
• 1-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol
• CGP 77675; CGP-77675
• 4-Piperidinol, 1-[2-[4-[4-aMino-5-(3-Methoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-7-yl]phenyl]ethyl]-

CGP77675

CAS: 234772-64-6

CGP77675

Formula: C₂₆H₂₉N₅O₂

Purity: 99.5%

Molecular weight: 443.54

Ref: 54-BUP11566

CGP77675

CAS: 234772-64-6

Formula: C₂₆H₂₉N₅O₂

Purity: 98%

Molecular weight: 443.5408

Ref: IN-DA002NCF

CGP 77675

CAS: 234772-64-6

CGP 77675 is a voltage-dependent calcium channel inhibitor that has shown to be an effective chemotherapeutic agent in prostate cancer cells. It has been shown to inhibit the activity of MMP-9, which is an enzyme involved in the degradation of the extracellular matrix and tumor growth. CGP 77675 also inhibits the activity of growth factor-β1, which is a protein that regulates cell proliferation and differentiation. In addition, it inhibits dna binding activity and chemical inhibitors in prostate cancer cells. The drug has significant cytotoxicity on carcinoma cell lines and basic fibroblast cells. CGP 77675 selectively binds to kinases with basic amino acid residues near the ATP binding site (e.g., epidermal growth factor receptor).

Formula: C₂₆H₂₉N₅O₂

Purity: Min. 95%

Molecular weight: 443.54 g/mol

Ref: 3D-JJA77264

CGP77675

CAS: 234772-64-6

CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and

Formula: C₂₆H₂₉N₅O₂

Purity: 99.66%

Color and Shape: White Solid

Molecular weight: 443.5408

Ref: TM-T30855