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RET V804M-IN-1
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RET V804M-IN-1

CAS: 2414909-94-5

Ref. 3D-EP176311

5mg
68.00 €
10mg
108.00 €
25mg
217.00 €
50mg
325.00 €
100mg
406.00 €
Estimated delivery in United States, on Tuesday 28 May 2024

Product Information

Name:
RET V804M-IN-1
Synonyms:
  • 4-[5-(3-Pyridylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide
Description:

Selective inhibitor of the mutated RET variant RETV804M, which is the anticipated drug-resistant RET mutant that can occur in tumours treated with kinase inhibitors. The compound has a biochemical IC50 of 0.02 µM and selectivity for purified RETV804M over purified RET and KDR of 3.7 and 110, respectively. The efficacy of the compound was shown also in cell cultures with IC50 of 4.4 µM, and cell assay selectivity for RETV804M over RET and KDR of 0.89 and 2.3, respectively.

Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
344.37 g/mol
Formula:
C19H16N6O
Purity:
Min. 97 Area-%
Color/Form:
White Powder
InChI:
InChI=1S/C19H16N6O/c20-18(26)15-5-3-14(4-6-15)16-12-23-25-9-7-17(24-19(16)25)22-11-13-2-1-8-21-10-13/h1-10,12H,11H2,(H2,20,26)(H,22,24)
InChI key:
InChIKey=LMGXQBQAUALFTB-UHFFFAOYSA-N
SMILES:
NC(=O)c1ccc(-c2cnn3ccc(NCc4cccnc4)nc23)cc1
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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