CAS 24584-09-6

Dexrazoxane

Description:

Dexrazoxane is a synthetic compound primarily used as a cardioprotective agent in cancer therapy, particularly to mitigate the cardiotoxic effects of anthracycline chemotherapy agents like doxorubicin. It functions as a topoisomerase II inhibitor and is also known for its ability to chelate iron, thereby reducing oxidative stress and free radical formation in cardiac tissues. Dexrazoxane is typically administered intravenously and is characterized by its relatively low solubility in water, which can influence its formulation and delivery. The compound has a molecular formula that reflects its complex structure, and it is classified as a member of the class of compounds known as benzamides. Its efficacy and safety profile have been evaluated in various clinical settings, leading to its approval for use in specific patient populations. While it is generally well-tolerated, potential side effects may include myelosuppression and gastrointestinal disturbances. Overall, dexrazoxane plays a crucial role in enhancing the therapeutic index of certain chemotherapeutic regimens by protecting the heart from damage.

Formula: C₁₁H₁₆N₄O₄

InChI: InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1

InChI key: InChIKey=BMKDZUISNHGIBY-ZETCQYMHSA-N

SMILES: C([C@H](C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2

Synonyms:

• 4,4'-(2S)-Propan-1,2-diyldipiperazin-2,6-dion
• 4,4'-(2S)-propane-1,2-diyldipipérazine-2,6-dione
• (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane
• Eucardion
• 4,4′-[(1S)-1-Methyl-1,2-ethanediyl]bis[2,6-piperazinedione]
• 2,6-piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-
• 4,4'-(2S)-Propane-1,2-diyldipiperazine-2,6-dione
• 2,6-Piperazinedione, 4,4′-(1-methyl-1,2-ethanediyl)bis-, (S)-
• 2,6-Piperazinedione, 4,4′-propylenedi-, (+)-
• (+)-4,4'-Propylenedi-2,6-piperazinedione
• (+)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione
• 4,4'-[(2S)-1,2-Propanediyl]di(2,6-piperazinedione)
• (S)-4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-2,6-PIPERAZINEDIONE

Dexrazoxane

CAS: 24584-09-6

Formula: C₁₁H₁₆N₄O₄

Purity: >98.0%(T)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 268.27

Ref: 3B-D4227

4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione

CAS: 24584-09-6

Formula: C₁₁H₁₆N₄O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 268.2691

Ref: IN-DA002ONZ

Dexrazoxane ((S)-Razoxane)

CAS: 24584-09-6

Formula: C₁₁H₁₆N₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 268.27

Ref: 4Z-R-088001

Dexrazoxane

CAS: 24584-09-6

Dexrazoxane

Purity: ≥98%

Molecular weight: 268.27g/mol

Ref: 54-BUP14015

Dexrazoxane

CAS: 24584-09-6

Dexrazoxane

Purity: 98%

Molecular weight: 268.27g/mol

Ref: 54-OR1027793

Dexrazoxane

CAS: 24584-09-6

Dexrazoxane (ICRF-187) is a mitosis-blocking anticancer drug, iron chelator, and anthracycline cardioprotectant.

Formula: C₁₁H₁₆N₄O₄

Purity: 99.88%

Color and Shape: Solid

Molecular weight: 268.27

Ref: TM-T22305

Dexrazoxane

CAS: 24584-09-6

Formula: C₁₁H₁₆N₄O₄

Purity: ≥ 98.0% (dried basis)

Color and Shape: White to off-white, pale yellow or beige powder or crysals

Molecular weight: 268.27

Ref: 7W-GP2739

(S)-Razoxane

CAS: 24584-09-6

Formula: C₁₁H₁₆N₄O₄

Molecular weight: 268.27

Ref: ST-EA-CP-R94001

Dexrazoxane

Controlled Product

CAS: 24584-09-6

Applications Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
References Walker, D., et al.: Pediatr. Blood Cancer 60,616 (2013); Kang, M., et al.: J. Chemother., 24, 292 (2012); Lipshultz, S., et al.: New England J. Med., 35, 145 (2004)

Formula: C₁₁H₁₆N₄O₄

Color and Shape: Neat

Molecular weight: 268.27

Ref: TR-D299050

Dexrazoxane

CAS: 24584-09-6

Topoisomerase II inhibitor; iron chelator

Formula: C₁₁H₁₆N₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 268.27 g/mol

Ref: 3D-FD65001

Dexrazoxane - Bio-X ™

CAS: 24584-09-6

Dexrazoxane is a cytoprotective drug that is used in chemotherapy to provide cardio-protection against anthracycline toxicity. It is an antimitotic agent with immunosuppressive properties. Dexrazoxane works by binding to iron in the cell, preventing it from being released. Dexrazoxane is also a catalytic inhibitor of topoisomerase II.

Formula: C₁₁H₁₆N₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 268.27 g/mol

Ref: 3D-BD164365

(S)-4,4′-(Propane-1,2-diyl)bis(piperazine-2,6-dione)

CAS: 24584-09-6

Formula: C₁₁H₁₆N₄O₄

Purity: 98% (HPLC)

Color and Shape: Solid

Molecular weight: 268.273

Ref: 10-F093447