CAS 24584-09-6: Dexrazoxane

Description: Dexrazoxane is a synthetic compound primarily used as a cardioprotective agent in cancer therapy, particularly to mitigate the cardiotoxic effects of anthracycline chemotherapy agents like doxorubicin. It functions as a topoisomerase II inhibitor and is also known for its ability to chelate iron, thereby reducing oxidative stress and free radical formation in cardiac tissues. Dexrazoxane is typically administered intravenously and is characterized by its relatively low solubility in water, which can influence its formulation and delivery. The compound has a molecular formula that reflects its complex structure, and it is classified as a member of the class of compounds known as benzamides. Its efficacy and safety profile have been evaluated in various clinical settings, leading to its approval for use in specific patient populations. While it is generally well-tolerated, potential side effects may include myelosuppression and gastrointestinal disturbances. Overall, dexrazoxane plays a crucial role in enhancing the therapeutic index of certain chemotherapeutic regimens by protecting the heart from damage.

Formula: C₁₁H₁₆N₄O₄

InChI: InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1

InChI key: InChIKey=BMKDZUISNHGIBY-ZETCQYMHSA-N

SMILES: O=C1NC(=O)CN(C1)CC(N2CC(=O)NC(=O)C2)C

Synonyms:

• 4,4'-(2S)-Propan-1,2-diyldipiperazin-2,6-dion
• 4,4'-(2S)-propane-1,2-diyldipipérazine-2,6-dione
• (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane
• Eucardion
• 4,4′-[(1S)-1-Methyl-1,2-ethanediyl]bis[2,6-piperazinedione]
• 2,6-piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-
• 4,4'-(2S)-Propane-1,2-diyldipiperazine-2,6-dione
• 2,6-Piperazinedione, 4,4′-(1-methyl-1,2-ethanediyl)bis-, (S)-
• 2,6-Piperazinedione, 4,4′-propylenedi-, (+)-
• (+)-4,4'-Propylenedi-2,6-piperazinedione
• (+)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione
• 4,4'-[(2S)-1,2-Propanediyl]di(2,6-piperazinedione)
• (S)-4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-2,6-PIPERAZINEDIONE
• 2,6-Piperazinedione, 4,4′-[(1S)-1-methyl-1,2-ethanediyl]bis-

Dexrazoxane

CAS: 24584-09-6

• Formula: C₁₁H₁₆N₄O₄
• Purity: >98.0%(T)
• Color and Shape: White to Light yellow to Light orange powder to crystal
• Molecular weight: 268.27

2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-

CAS: 24584-09-6

• Formula: C₁₁H₁₆N₄O₄
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 268.2691

Dexrazoxane ((S)-Razoxane)

CAS: 24584-09-6

• Formula: C₁₁H₁₆N₄O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 268.27

Dexrazoxane

CAS: 24584-09-6

Dexrazoxane (ICRF-187) is a mitosis-blocking anticancer drug, iron chelator, and anthracycline cardioprotectant.

• Formula: C₁₁H₁₆N₄O₄
• Purity: 99.45%
• Color and Shape: Solid
• Molecular weight: 268.27

Dexrazoxane

CAS: 24584-09-6

• Formula: C₁₁H₁₆N₄O₄
• Purity: ≥ 98.0% (dried basis)
• Color and Shape: White to off-white, pale yellow or beige powder or crysals
• Molecular weight: 268.27

(S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione)

CAS: 24584-09-6

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 268.27301025390625

Dexrazoxane

CAS: 24584-09-6

Topoisomerase II inhibitor; iron chelator

• Formula: C₁₁H₁₆N₄O₄
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 268.27 g/mol

Dexrazoxane - Bio-X ™

CAS: 24584-09-6

Dexrazoxane is a cytoprotective drug that is used in chemotherapy to provide cardio-protection against anthracycline …

• Formula: C₁₁H₁₆N₄O₄
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 268.27 g/mol

Dexrazoxane

CAS: 24584-09-6

Applications Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced …

• Formula: C₁₁H₁₆N₄O₄
• Color and Shape: Neat
• Molecular weight: 268.27