CAS 25316-40-9: Doxorubicin hydrochloride

Description: Doxorubicin hydrochloride is an anthracycline antibiotic commonly used in cancer chemotherapy. It is characterized by its bright red color and is known for its potent antitumor activity. The compound works by intercalating DNA, thereby inhibiting the synthesis of nucleic acids and disrupting the replication of cancer cells. Doxorubicin is soluble in water and exhibits a pH-dependent solubility profile, which is important for its formulation and administration. Its mechanism of action also involves the generation of free radicals, contributing to its cytotoxic effects. However, the use of doxorubicin is associated with several side effects, including cardiotoxicity, which limits its cumulative dose. It is typically administered intravenously and is often used in combination with other chemotherapeutic agents to enhance efficacy against various malignancies, including breast cancer, leukemia, and lymphomas. Due to its significant therapeutic benefits and potential risks, careful monitoring and management are essential during treatment.

Formula: C₂₇H₂₉NO₁₁·ClH

InChI: InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

InChI key: InChIKey=MWWSFMDVAYGXBV-RUELKSSGSA-N

SMILES: Cl.O=C1C=2C=CC=C(OC)C2C(=O)C=3C(O)=C4C(=C(O)C13)CC(O)(C(=O)CO)CC4OC5OC(C)C(O)C(N)C5

Synonyms:

• (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1)
• (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride (1:1)
• (8S-Cis)-10-((3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxynaphthacene-5,12-Dione Hydrochloride
• (8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid
• (8S-cis)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
• (8S-cis)-10-[(3-amino-2,3,6-tridesoxi-α-L-lyxo-hexopiranosil)oxi]-7,8,9,10-tetrahidro-6,8,11-trihidroxi-8-(hidroxiacetil)-1-metoxinaftaceno-5,12-diona, clorhidrato
• (8S-cis)-10-[(3-amino-2,3,6-tridesoxy-α-L-lyxo-hexopyrannosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphtacene-5,12-dione, chlorhydrate
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
• ADM hydrochloride
• ADR
• Adriablastina CS
• Adriacin
• Adriamycin
• Adriamycin, hydrochloride
• Adriblastin
• Adriblastina
• Adriblastina RD
• Adrosal
• Ameisu hydrochloride
• Caelyx pegylated liposomal
• DOX HCl
• Doxolipad
• Doxorubicin, HCl
• Doxorubicin-LANS
• Doxorubicin-TEVA
• Doxourbicin HCl
• Fi 106
• Fi 6804
• Hydroxydaunorubicin hydrochloride
• Lipo-Dox
• Lipodox
• Myocet liposomal
• Doxorubicin hydrochloride

Doxorubicin Hydrochloride

CAS: 23214-92-8 25316-40-9

• Formula: C₂₇H₂₉NO₁₁·HCl
• Purity: >95.0%(HPLC)
• Color and Shape: Light yellow to Brown powder to crystal
• Molecular weight: 579.98

Doxorubicin hydrochloride

CAS: 25316-40-9

Antitumor antibiotic agent that inhibits DNA topoisomerase II.Doxorubicin hydrochloride is used as an antineoplastic, antibiotic …

• Formula: C₂₇H₃₀ClNO₁₁
• Color and Shape: Crystalline powder or granular, Red to orange
• Molecular weight: 579.98

Doxorubicin hydrochloride RS

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁
• Molecular weight: 543.5193

Doxorubicin hydrochloride CRS

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁
• Color and Shape: Crystalline Powder. Orange. Red. Powder.
• Molecular weight: 543.5193

Doxorubicin hydrochloride

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁HCl
• Purity: 99.0%
• Color and Shape: Orange To Dark Red
• Molecular weight: 579.15074

Doxorubicin Hydrochloride

CAS: 25316-40-9

Antibiotics nesoi

• Formula: C₂₇H₂₉NO₁₁·ClH
• Color and Shape: Red Orange Crystalline Powder Amorphous Powder
• Molecular weight: 579.15074

Doxorubicin hydrochloride

CAS: 25316-40-9

Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of …

• Formula: C₂₇H₂₉NO₁₁·HCl
• Purity: 98% - 99.57%
• Color and Shape: Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)
• Molecular weight: 579.99

(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride

CAS: 25316-40-9

• Formula: C₂₇H₃₀ClNO₁₁
• Purity: %
• Color and Shape: Solid
• Molecular weight: 579.9802

Doxorubicin HCl (Daunorubicin EP Impurity D HCl, Epirubicin EP Impurity C HCl)

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁·HCl
• Color and Shape: Red Solid
• Molecular weight: 543.53 36.46

Doxorubicin hydrochloride

CAS: 25316-40-9

• Purity: ≥98%
• Molecular weight: 579.99g/mol

Doxorubicin hydrochloride

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁·ClH
• Purity: 99%
• Color and Shape: orange red crystalline powder
• Molecular weight: 579.98g/mol

Doxorubicin hydrochloride, 98%

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁·HCl
• Purity: (HPLC) 98.0 - 102.0 % (anhydrous, solvent free)
• Color and Shape: Orange-red to red crystalline powder
• Molecular weight: 579.99

Doxorubicin hydrochloride

CAS: 25316-40-9

• Purity: 95.0%
• Color and Shape: Solid, Crystalline Powder or Granules or Powder
• Molecular weight: 579.15073846

Doxorubicin Hydrochloride

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁·ClH
• Color and Shape: Neat
• Molecular weight: 579.98

Doxorubicin hydrochloride, USP grade

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁·HCl
• Purity: ≥ 98.0% (anhydrous, solvent-free)
• Color and Shape: Orange-red to red crystalline powder
• Molecular weight: 579.99

Doxorubicin-13C-d3 HCl

CAS: 25316-40-9

• Formula: CC₂₂H₂₆NO₁₁D₃·HCl
• Molecular weight: 547.56 36.45

Doxorubicin Hydrochloride RS

CAS: 25316-40-9

• Color and Shape: Red-Orange Solid Crystalline Powder

Doxorubicin Hydrochloride

CAS: 25316-40-9

Stability Hygroscopic, Light Sensitive Applications Doxorubicin Hydrochloride is an antineoplastic agent. References Di Marco, A., …

• Formula: C₂₇H₂₉NO₁₁·ClH
• Color and Shape: Neat
• Molecular weight: 579.98

Doxorubicin hydrochloride - Bio-X ™

CAS: 25316-40-9

Doxorubicin hydrochloride is an inhibitor of topoisomerase II with anti-neoplastic activity and belongs to the …

• Formula: C₂₇H₂₉NO₁₁•HCl
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 579.98 g/mol

Doxorubicin HCl

CAS: 25316-40-9

Inhibitor of topoisomerase II with anti-neoplastic activity. The compound interferes with the topoisomerase II-mediated repair …

• Formula: C₂₇H₂₉NO₁₁·HCl
• Purity: Min. 98 Area-%
• Color and Shape: Red Powder
• Molecular weight: 579.98 g/mol