CAS 25775-90-0

Zucapsaicin

Description:

Zucapsaicin is a topical analgesic that was approved in Canada in July 2010 for use in conjunction with oral COX-2 inhibitors or NSAIDs to relieve severe pain in adults with osteoarthritis of the knee. Zucapsaicin is the cis-isomer of the natural product capsaicin. Capsaicin is available without a prescription in creams, lotions, and patches for the treatment of neuropathic and musculoskeletal pain. Zucapsaicin is available as a 0.075% by weight cream. The advantages of zucapsaicin compared with capsaicin are reported to be a lesser degree of local irritation (stinging, burning, erythema) in patients and a greater degree of efficacy in preclinical animal models of pain. The analgesic action of zucapsaicin and capsaicin is mediated through the transient receptor potential vanilloid type 1 (TRPV1) channel.

Formula: C₁₈H₂₇NO₃

InChI: InChI=1/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+

InChI key: InChIKey=YKPUWZUDDOIDPM-VURMDHGXSA-N

SMILES: C(NC(CCCC/C=C\C(C)C)=O)C1=CC(OC)=C(O)C=C1

Synonyms:

• (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide
• (6Z)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide
• (6Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
• (Z)-8-Methyl-N-vanillyl-6-nonenamide
• (Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
• 6-Nonenamide, 8-methyl-N-vanillyl-, (Z)-
• 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6Z)-
• 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (Z)-
• Capsaicin, cis-
• Civamide
• Zucapsaicin
• cis-Capsaicin
• Zucapsaicin（cis-Capsaicin）
• (Z)-CAPSAICIN / Zucapsaicin
• ZUCAPSAICIN;CIS-CAPSAICIN;CIVAMIDE;(Z)-CAPSAICIN
• (Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
• (Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide
• (Z)-N-(4-Hydroxy-3-Methoxybenzyl)-8-Methylnon-6-enaMide
• (Z)-8-Methyl-N-(4-hydroxy-3-methoxybenzyl)-6-noneneamide
• Civamide (Zucapsaicin)
• (Z)-N-[(4-Hydoxy-3-methoxyphenyl)methyl]-8-metyl-6-nonenamide
• (Z)-Capsaicin、Civamide
• Zucapsaicin,civaMide
• (z)-6-nonenamid
• (Z)-CAPSAICIN
• 8-Methyl-N-vanillyl-6-nonenamide
• n-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide(z)-
• cis-Capsaicine

(Z)-Capsaicin

CAS: 25775-90-0

(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer of

Formula: C₁₈H₂₇NO₃

Purity: 97.33% - 98.91%

Color and Shape: Solid

Molecular weight: 305.41

Ref: TM-T1109

(6Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide

CAS: 25775-90-0

Formula: C₁₈H₂₇NO₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 305.4119

Ref: IN-DA00I4X6

(Z)-Capsaicin

CAS: 25775-90-0

(Z)-Capsaicin

Formula: C₁₈H₂₇NO₃

Purity: ≥95%

Molecular weight: 305.41

Ref: 54-BUP14497

(Z)-N-(4-HYDROXY-3-METHOXYBENZYL)-8-METHYLNON-6-ENAMIDE

CAS: 25775-90-0

(Z)-N-(4-HYDROXY-3-METHOXYBENZYL)-8-METHYLNON-6-ENAMIDE

Formula: C₁₈H₂₇NO₃

Purity: 95%

Molecular weight: 305.41

Ref: 54-OR1025832

Zucapsaicin

Controlled Product

CAS: 25775-90-0

Formula: C₁₈H₂₇NO₃

Color and Shape: White Solid

Molecular weight: 305.41

Ref: 86-MM3732.00

cis-Capsaicin

CAS: 25775-90-0

Formula: C₁₈H₂₇NO₃

Molecular weight: 305.42

Ref: 4Z-C-874

Cis Capsaicin

CAS: 25775-90-0

Formula: C₁₈H₂₇NO₃

Molecular weight: 305.42

Ref: ST-EA-CP-C168006

cis-Capsaicin

Controlled Product

CAS: 25775-90-0

Stability Light Sensitive
Applications Capsaicin analogue (C175680). It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Artursson., et al.: J. Pharma. Sci., 73, 1507 (1984), Fu., et al.: Pharma. Res., 2000, 17, 100 (2000),

Formula: C₁₈H₂₇NO₃

Color and Shape: Neat

Molecular weight: 305.41

Ref: TR-C175690

cis-Capsaicin

CAS: 25775-90-0

cis-Capsaicin is an isomeric form of capsaicin, which is a naturally occurring compound primarily derived from chili peppers of the genus Capsicum, such as Capsicum annuum. While trans-Capsaicin is the most prevalent form, cis-Capsaicin differs in its geometric configuration. This structural variation influences its interaction with biological systems.

Formula: C₁₈H₂₇NO₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 305.41 g/mol

Ref: 3D-FC19671