CAS 25953-19-9

Cefazolin

Description:

Cefazolin is a first-generation cephalosporin antibiotic, primarily used for the treatment of bacterial infections. It is effective against a variety of gram-positive bacteria and some gram-negative organisms. Cefazolin works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. The compound is typically administered via injection, as it is not well absorbed from the gastrointestinal tract. Its chemical structure includes a beta-lactam ring, which is essential for its antibacterial activity. Cefazolin is often used in surgical prophylaxis and for treating infections such as skin and soft tissue infections, urinary tract infections, and respiratory tract infections. It is generally well-tolerated, but potential side effects may include allergic reactions, gastrointestinal disturbances, and alterations in blood clotting. As with all antibiotics, it is crucial to use cefazolin judiciously to prevent the development of antibiotic resistance. Its CAS number, 25953-19-9, uniquely identifies this compound in chemical databases.

Formula: C₁₄H₁₄N₈O₄S₃

InChI: InChI=1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1

InChI key: InChIKey=MLYYVTUWGNIJIB-BXKDBHETSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(CN3C=NN=N3)=O)C2=O)(SCC1CSC=4SC(C)=NN4)[H]

Synonyms:

• (6R,7R)-3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R-trans)-3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[(1H-tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[(1H-tetrazol- 1-ylacetyl)amino]-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-, (6R-trans)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-, (6R,7R)-
• 7-(1-(1H)-Tetrazolylacetamido)-3-[2-(5-methyl-1,3,4-thiadiazolyl)thiomethyl]-Δ3-cephem-4-carboxylic acid
• 7-(1-(1H)-Tetrazolylacetamido)-3-[2-(5-methyl-1,3,4-thiadiazolyl)thiomethyl]-Δ³-cephem-4-carboxylic acid
• 7-(1H-Tetrazol-1-ylacetamido)-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid
• 7-[1-(1H)-tetrazolylacetoamido]-3-[2-(5-methyl-1,3,4-thiadiazolyl)-thiomethyl]-Δ-3-cephem-4-carboxylic acid
• CEZ
• Cefamedin
• Cefamezin
• Cefaprim
• Cefazolin,sodium salt
• Cefazolina
• Cefazoline
• Cephamezine
• Cephazolin
• Cephazolin,sodium salt
• Cephazoline
• Elzogram
• Sefazol
• Zinol
• CEFAZOLIN
• 7-(1-(1h-)-tetrazolylacetamido)-3-[2-(5-methyl-1,3,4-thiadiazolyl)thiomethyl]d
• diazol-2-yl)thio)methyl)-8-oxo-7-(2-(1h-tetrazol-1-yl)acetamido)-
• CEFAZOLIN ACID
• diazol-2-yl)thio)methyl)-8-oxo-7-((1h-tetra
• diazol-2-yl)thio)methyl)-8-oxo-7-(2-(1h-t-
• elta3-cephem-4-carboxylicacid
• (6r-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[(1h-tetr
• CefazoilnV
• Cefazoline sodium sterile IP/Bp
• azol-1-yl)acetyl]-amino]-5-thia-1-azabicylo

Cefazolin Sodium Salt

CAS: 25953-19-9, 27164-46-1

Formula: C₁₄H₁₃N₈NaO₄S₃

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 476.48

Ref: 3B-C2242

CEFAZOLIN CRS

CAS: 25953-19-9

CEFAZOLIN CRS

Formula: C₁₄H₁₄N₈O₄S₃

Molecular weight: 454.5072

Ref: 41-C0682800

Cefazolin

CAS: 25953-19-9

Antibiotics nesoi

Formula: C₁₄H₁₄N₈O₄S₃

Color and Shape: White Powder

Molecular weight: 454.51

Ref: 45-1097603

Cefazolin

CAS: 25953-19-9

Formula: C₁₄H₁₄N₈O₄S₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 454.5072

Ref: IN-DA007N59

Cefazolin

CAS: 25953-19-9

Cefazolin

Purity: ≥98%

Molecular weight: 454.51g/mol

Ref: 54-BUP16461

Cefazolin Impurity 45

CAS: 2101505-58-0, 25953-19-9

Formula: C₁₃H₁₄N₆O₆S

Color and Shape: White To Off-White Solid

Molecular weight: 382.35

Ref: 4Z-C-9666

Cefazolin

CAS: 25953-19-9

Formula: C₁₄H₁₄N₈O₄S₃

Purity: ≥ 98.0% (dry basis)

Color and Shape: White to off-white powder

Molecular weight: 454.51

Ref: 7W-GA2577

Cefazolin 1000 µg/mL in Acetonitrile

Controlled Product

CAS: 25953-19-9

Formula: C₁₄H₁₄N₈O₄S₃

Color and Shape: Single Solution

Molecular weight: 454.51

Ref: 04-A11064090AL-1000

Cefazolin

CAS: 25953-19-9

Cefazolin is a semi-synthetic cephalosporin that has a broad spectrum of antibacterial activity and inhibits the synthesis of bacterial cell walls.

Formula: C₁₄H₁₄N₈O₄S₃

Purity: 99.51%

Color and Shape: Needles From Aqueous Acetone Solid

Molecular weight: 454.51

Ref: TM-T8390

Cefazolin RS

CAS: 25953-19-9

Color and Shape: White To Pale Yellowish White Solid Crystalline Powder

Ref: 2K-7000390021

Cefazolin

Controlled Product

CAS: 25953-19-9

Applications Cefazolin is an antibacterial compound derived from 7-amino-cephalosporanic acid.
References Kozatani, et al.: Chem. Pharm. Bull., 20, 1105 (1972), Birkhead, H.A., et al.: J. Infect. Dis., 128, 379 (1973), Zappala, A.E., et al.: Anal. Profiles Drug Subs., 4, 1 (1975),

Formula: C₁₄H₁₄N₈O₄S₃

Color and Shape: White To Off-White

Molecular weight: 454.51

Ref: TR-C242495

Cefazolin

CAS: 25953-19-9

Purity: 98%

Molecular weight: 454.5

Ref: 10-F863147

L-Cefazolin

Controlled Product

CAS: 25953-19-9

Formula: C₁₄H₁₄N₈O₄S₃

Color and Shape: Neat

Molecular weight: 454.507

Ref: TR-L242600

Cefazolin, Antibiotic for Culture Media Use Only

CAS: 25953-19-9

Cefazolin is a semi-synthetic, non-beta lactam antibiotic used for the treatment of a variety of bacterial infections. It inhibits cell wall synthesis by binding to one or more of penicillin-binding proteins (PBPs), which are bacterial transpeptidases that crosslink peptidoglycan strands. Cefazolin binds to PBPs present on the surface of all Gram-negative bacteria as well as many Gram-positive bacteria. It is not effective against methicillin-resistant staphylococcus and MRSA unless combined with another antibiotic such as vancomycin or flucloxacillin. A study showed that cefazolin can decrease inflammation and tumor necrosis factor-beta levels in pregnant women with systemic inflammatory disease. It has been tested in the development of an anti-inflammatory agent for use in patients with autoimmune diseases such as rheumatoid arthritis and lupus erythe.

Formula: C₁₄H₁₄N₈O₄S₃

Molecular weight: 454.51 g/mol

Ref: 3D-W-107209

Cefazolin

CAS: 25953-19-9

Cefazolin is a broad-spectrum antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria. It is an effective cephalosporin antibiotic against both aerobic and anaerobic bacteria. Cefazolin is used in clinical isolates to inhibit the growth of methicillin-resistant staphylococcus, resistant microorganisms, and systemic inflammation. Some studies has shown good results to inhibit tumor necrosis factor-α (TNFα) production in cell culture.

Formula: C₁₄H₁₄N₈O₄S₃

Purity: Min. 95%

Molecular weight: 454.51 g/mol

Ref: 3D-AC172185