CAS 288383-20-0: Cediranib

Description: Cediranib, with the CAS number 288383-20-0, is a small molecule inhibitor primarily known for its role as a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR) tyrosine kinases. It is classified as an anti-cancer agent, particularly in the treatment of various solid tumors, including non-small cell lung cancer and ovarian cancer. Cediranib exhibits characteristics such as a relatively low molecular weight and a specific chemical structure that allows it to effectively block angiogenesis, the process through which new blood vessels form from pre-existing ones, which is crucial for tumor growth and metastasis. The compound is typically administered orally and has been studied in clinical trials for its efficacy and safety profile. Its mechanism of action involves the inhibition of VEGF signaling pathways, leading to reduced tumor vascularization and growth. As with many targeted therapies, potential side effects may include hypertension, fatigue, and gastrointestinal disturbances, necessitating careful monitoring during treatment.

Formula: C₂₅H₂₇FN₄O₃

InChI: InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3

InChI key: InChIKey=XXJWYDDUDKYVKI-UHFFFAOYSA-N

SMILES: FC1=C(OC2=NC=NC=3C=C(OCCCN4CCCC4)C(OC)=CC23)C=CC=5NC(=CC15)C

Synonyms:

• 4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline
• 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline
• 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline
• 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline
• Azd 2171
• Azd2171
• Quinazoline, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-
• Zd 2171
• Cediranib

Quinazoline,4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-

CAS: 288383-20-0

• Formula: C₂₅H₂₇FN₄O₃
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 450.5053

Cediranib

CAS: 288383-20-0

• Formula: C₂₅H₂₇FN₄O₃
• Molecular weight: 450.51

Cediranib

CAS: 288383-20-0

• Purity: 99.78%
• Molecular weight: 450.51g/mol

Cediranib

CAS: 288383-20-0

• Formula: C₂₅H₂₇FN₄O₃
• Purity: >95.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 450.51

Cediranib

CAS: 288383-20-0

Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, …

• Formula: C₂₅H₂₇FN₄O₃
• Purity: 97.21% - 99.94%
• Color and Shape: Solid
• Molecular weight: 450.51

Cediranib

CAS: 288383-20-0

• Formula: C₂₅H₂₇FN₄O₃
• Purity: 99.82% (Typical Value in Batch COA)
• Color and Shape: off-white solid
• Molecular weight: 450.51g/mol

Cediranib

CAS: 288383-20-0

• Purity: 99.0%
• Molecular weight: 450.5140075683594

Cediranib

CAS: 288383-20-0

Inhibitor of VEGF receptor tyrosine kinases and non-receptor tyrosine kinases

• Formula: C₂₅H₂₇FN₄O₃
• Purity: Min. 98 Area-%
• Color and Shape: White To Off-White Solid
• Molecular weight: 450.20672

Cediranib

CAS: 288383-20-0

Applications Cediranib is a drug for blocking angiogenesis, study on cervical cancer molecular targeted drug …

• Formula: C₂₅H₂₇FN₄O₃
• Color and Shape: Neat
• Molecular weight: 450.51