CAS 28957-04-2

Oridonin

Description:

Oridonin is a natural compound classified as a diterpenoid, primarily derived from the plant Rabdosia rubescens, which is known for its traditional medicinal uses in Chinese herbal medicine. This compound exhibits a range of biological activities, including anti-inflammatory, anti-tumor, and antimicrobial properties, making it a subject of interest in pharmacological research. Oridonin's structure features a fused ring system typical of many diterpenoids, contributing to its biological activity. It is soluble in organic solvents but has limited solubility in water, which can influence its bioavailability and therapeutic applications. The compound has been studied for its potential effects on various cancer cell lines, showing promise in inducing apoptosis and inhibiting cell proliferation. Additionally, oridonin's mechanism of action may involve the modulation of signaling pathways related to cell survival and death. Overall, oridonin represents a significant area of interest for further research in drug development and natural product chemistry.

Formula: C₂₀H₂₈O₆

InChI: InChI=1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13?,15+,16?,18+,19-,20+/m0/s1

InChI key: InChIKey=SDHTXBWLVGWJFT-VSKLWXMZSA-N

SMILES: O[C@]12[C@]34[C@]([C@]5(C([C@@H]1O)(C(C)(C)CC[C@@H]5O)[H])CO2)(CC[C@]([C@H]3O)(C(=C)C4=O)[H])[H]

Synonyms:

• (1alpha,5beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R)-1,6,7,14-tetrahydroxy-7,20-epoxykaur-16-en-15-one
• (1alpha,5beta,6beta,7beta,9xi,10xi,14S)-1,6,7,14-tetrahydroxy-7,20-epoxykaur-16-en-15-one
• (1alpha,5beta,6beta,9beta,14S)-1,6,7,14-tetrahydroxy-7,20-epoxykaur-16-en-15-one
• (1α,6β,7α,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one
• (6Beta,7Beta)-1,6,7,14-Tetrahydroxy-7,20-Epoxykaur-16-En-15-One
• 6,11b-(Epoxymethano)-6a,9-methano-1H-cyclohepta[a]naphthalene, kaur-16-en-15-one deriv.
• Isodonal
• Isodonol
• Kaur-16-en-15-one, 7,20-epoxy-1,6,7,14-tetrahydroxy-, (1α,6β,7α,14R)-
• Kaur-16-en-15-one, 7α,20-epoxy-1α,6β,7,14-tetrahydroxy-, (14R)-
• NSC 250682
• Oridonine
• rubescensin A

Kaur-16-en-15-one, 7,20-epoxy-1,6,7,14-tetrahydroxy-, (1α,6β,7α,14R)-

CAS: 28957-04-2

Formula: C₂₀H₂₈O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 364.4327

Ref: IN-DA002UZH

Oridonin

CAS: 28957-04-2

Oridonin

Purity: 98%

Molecular weight: 364.43g/mol

Ref: 54-OR1027893

Oridonin

CAS: 28957-04-2

Oridonin

Purity: ≥90%

Molecular weight: 364.44g/mol

Ref: 54-BUP14473

Oridonin

CAS: 28957-04-2

Oridonin has anticancer activity, might be useful as adjunctive therapy for individuals with lymphoid malignancies, including the lethal disease adult T-cell leukemia.It inhibits tumor growth in glioma by inducing cell cycle arrest and apoptosis, inhibits BxPC-3 cell growth through cell apoptosis.

Formula: C₂₀H₂₈O₆

Purity: 95%~99%

Molecular weight: 364.438

Ref: BP-BP1041

Oridonine

CAS: 28957-04-2

Formula: C₂₀H₂₈O₆

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 364.44

Ref: 3B-O0387

Oridonin

CAS: 28957-04-2

Formula: C₂₀H₂₈O₆

Molecular weight: 364.44

Ref: 4Z-O-099001

Oridonin

CAS: 28957-04-2

Oridonin, a diterpenoid from Rabdosia rubescens, has anti-tumor, anti-bacterial, and anti-inflammatory properties, inhibiting AKT1/2.

Formula: C₂₀H₂₈O₆

Purity: 94.25% - >99.99%

Color and Shape: Powder

Molecular weight: 364.44

Ref: TM-T2790

Rubescensin

CAS: 28957-04-2

Formula: C₂₀H₂₈O₆

Molecular weight: 364.43

Ref: 7W-GP6560

Oridonin

CAS: 28957-04-2

Oxygen-heterocyclic compound

Formula: C₂₀H₂₈O₆

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 364.44

Ref: 5G-89745

Oridonin

CAS: 28957-04-2

A diterpenoid from Chinese medicinal plant Rabdosia rubescens with anti-inflammatory activity. It is a potent inhibitor of NF-κB and MAPK activation and suppresses the release of proinflammatory cytokines. It is also a covalent inhibitor of NLRP3, a sensor component of NLRP3 inflammasome. In a rodent model for cerebral amyloidosis, oridonin effectively prevented neuroinflammation and Alzheimer’s disease-associated neuropathological changes. It reduced numbers of amyloid-β plaques in mice brain and reversed behaviour and social impairment.

Formula: C₂₀H₂₈O₆

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 364.44 g/mol

Ref: 3D-FO09522

Oridonin - Bio-X ™

CAS: 28957-04-2

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₀H₂₈O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 364.44 g/mol

Ref: 3D-BO300107

Oridonin

CAS: 28957-04-2

Formula: C₂₀H₂₈O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 364.438

Ref: 10-F462709

Oridonin

Controlled Product

CAS: 28957-04-2

Applications Oridonin is an effective anticancer agent due to its ability to inhibit proliferation and induce apoptosis of human osteosarcoma cells. Blocks Wnt/β-catenin signalling.
References Liu, Y. et al.: Int. J. Onc., 45, 795 (2014);

Formula: C₂₀H₂₈O₆

Color and Shape: Neat

Molecular weight: 364.43

Ref: TR-O674700