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CAS 298-57-7

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Cinnarizine

Description:
Cinnarizine is a chemical compound classified as a piperazine derivative and is primarily used as an antihistamine and antiemetic. Its chemical formula is C26H28N2, and it features a complex structure that includes a diphenylmethyl group and a piperazine ring. Cinnarizine is known for its ability to inhibit calcium channels, which contributes to its effectiveness in treating motion sickness and vertigo. It exhibits moderate lipophilicity, allowing it to cross the blood-brain barrier, which is significant for its central nervous system effects. The compound is typically administered in oral form and is well-absorbed in the gastrointestinal tract. Cinnarizine may cause side effects such as drowsiness, dry mouth, and gastrointestinal disturbances. It is important to note that while it is effective for certain conditions, its use should be monitored due to potential interactions with other medications and its sedative properties. Overall, cinnarizine is a valuable therapeutic agent in the management of vestibular disorders and motion-related ailments.
Formula:C26H28N2
InChI:InChI=1/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-12,14-18,26H,13,19-22H2/b18-10+
InChI key:InChIKey=DERZBLKQOCDDDZ-UHFFFAOYSA-N
SMILES:C(N1CCN(CC=CC2=CC=CC=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4
Synonyms:
  • 1-(3-Phenylallyl)-4-(diphenylmethyl)piperazine
  • 1-(Diphenylmethyl)-4-(3-phenyl-2-propen-1-yl)piperazine
  • 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine
  • 1-(diphenylmethyl)-4-[(1E)-3-phenylprop-1-en-1-yl]piperazine
  • 1-Benzhydryl-4-Trans-Cinnamylpiperazine
  • 1-Benzhydryl-4-cinnamylpiperazine
  • 1-Cinnamyl-4-(diphenylmethyl)piperazine
  • 1-Cinnamyl-4-benzhydrylpiperazine
  • 1-Cynnamyl-4-diphenylmethylpiperazine
  • 1-Diphenylmethyl-4-cinnamoylpiperazine
  • See more synonyms
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