CAS 3109024-12-3

PROTAC CBP/p300/BRD4 Degrader-1

CAS: 3109024-12-3

PROTAC CBP/p300/BRD4 Degrader-1 is a dual-targeting PROTAC degrader with DC50 values of 8.8 pM for BRD4, 6.55 nM for CBP, and 1.05 nM for p300. It facilitates CRBN and proteasome-dependent degradation of BRD4 and CBP/p300, leading to the downregulation of c-Myc and acetyl-H3K27, and triggers apoptosis. As an antiproliferative and antitumor agent, PROTAC CBP/p300/BRD4 Degrader-1 demonstrates tumor growth inhibition in xenograft models. It is applicable in research on prostate and colorectal cancers.

Formula: C₄₁H₄₂F₃N₇O₇

Molecular weight: 801.81

Ref: TM-T217857