CAS 31282-04-9: Hygromycin B

Description: Hygromycin B is an aminoglycoside antibiotic produced by the bacterium *Micromonospora hygroscopicus*. It is primarily known for its ability to inhibit protein synthesis in bacteria and some eukaryotic cells, making it a valuable tool in molecular biology for selecting genetically modified organisms. Hygromycin B is effective against a broad spectrum of microorganisms, including certain Gram-positive and Gram-negative bacteria, as well as fungi. Its mechanism of action involves binding to the ribosomal RNA, disrupting the translation process. The compound is typically used in laboratory settings for the selection of cells that have been transformed with hygromycin resistance genes. Hygromycin B is soluble in water and exhibits stability under various pH conditions, although it is sensitive to light and should be stored in a dark environment. Safety precautions are necessary when handling this compound, as it can be toxic to humans and other organisms at high concentrations. Overall, Hygromycin B is a crucial reagent in genetic engineering and cell biology research.

Formula: C₂₀H₃₇N₃O₁₃

InChI: InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20?/m1/s1

InChI key: InChIKey=GRRNUXAQVGOGFE-HUCHGKBZSA-N

SMILES: OCC1OC(OC2C(O)C(N)CC(NC)C2O)C3OC4(OC3C1O)OC(C(O)C(O)C4O)C(N)CO

Synonyms:

• (3'R,3aS,4S,4'R,5'R,6R,6'R,7S,7aS)-4-{[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)octahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-3',4',5',7-tetrol (non-preferred name)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-<smallcap>L</smallcap>-glycero-<smallcap>D</smallcap>-galacto-heptopyranosylidene-(1→2-3)-O-β-<smallcap>D</span>-talopyranosyl-(1→5)-2-deoxy-N³-methyl-
• Antihelmycin
• Hygromix 2.4
• Hygromix-8
• Hygromycin B
• Hygromycin B - Solution
• Hygromycin B Streptomyces hygroscopicus
• Hygromycin B solution Streptomyces hygroscopicus
• Hygrovetin
• Hygrovetine
• O-6-Amino-6-deoxy-<span class="text-smallcaps">L</smallcap>-glycero-<smallcap>D</smallcap>-galacto-heptopyranosylidene-(1→2-3)-O-β-<smallcap>D</smallcap>-talopyranosyl-(1→5)-2-deoxy-N³-methyl-<smallcap>D</span>-streptamine
• hygromycin B aqueous solution
• hygromycin B from streptomyces*hygroscopicus
• hygromycin B plant cell culture tested
• D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1→2-3)-O-β-D-talopyranosyl-(1→5)-2-deoxy-N3-methyl-
• O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1→2-3)-O-β-D-talopyranosyl-(1→5)-2-deoxy-N3-methyl-D-streptamine

Hygromycin B

CAS: 31282-04-9

• Formula: C₂₀H₃₇N₃O₁₃
• Purity: >80.0%(HPLC)
• Color and Shape: White to Light yellow to Light orange powder to crystal
• Molecular weight: 527.52

Hygromycin B

CAS: 31282-04-9

An aminoglycoside antibiotic that kills bacteria by inhibiting protein synthesisHygromycin B is used for the …

• Formula: C₂₀H₃₇N₃O₁₃
• Color and Shape: Cream to plale brown, Powder
• Molecular weight: 527.52

Hygromycin B, 50 mg/ml in distilled water, sterile-filtered

CAS: 31282-04-9

Hygromycin B was used for hygro resistance effect in the following cells transfected 293T cells …

• Formula: C₂₀H₃₇N₃O₁₃
• Color and Shape: Liquid, Pale yellow to brown
• Molecular weight: 527.52

Hygromycin B

CAS: 31282-04-9

Hygromycin B disrupts protein synthesis in 70S ribosomes, used as an anthelmintic in swine.

• Formula: C₂₀H₃₇N₃O₁₃
• Purity: 98% - 99.78%
• Color and Shape: solid
• Molecular weight: 527.52

Hygromycin B

CAS: 31282-04-9

• Purity: ≥98%
• Molecular weight: 527.52g/mol

Hygromycin B

CAS: 31282-04-9

• Formula: C₂₀H₃₇N₃O₁₃
• Purity: ≥ 90.0%
• Color and Shape: White to beige powder
• Molecular weight: 527.53

Hygromycin B

CAS: 31282-04-9

• Formula: C₂₀H₃₇N₃O₁₃
• Color and Shape: Neat
• Molecular weight: 527.52

Hygromycin B

CAS: 31282-04-9

• Formula: C₂₀H₃₇N₃O₁₃
• Molecular weight: 527.52

Hygromycin B, PBS solution

CAS: 31282-04-9

• Formula: C₂₀H₃₇N₃O₁₃
• Purity: (hplc) min. 90.0% 91.5% (Typical Value in Batch COA)
• Color and Shape: Liquid
• Molecular weight: 527.52g/mol

Hygromycin B, powder

CAS: 31282-04-9

• Formula: C₂₀H₃₇N₃O₁₃
• Purity: By hplc: 99.4% (Typical Value in Batch COA)
• Color and Shape: light tan powder
• Molecular weight: 527.52g/mol

Hygromycin B Deuterated (d4 major)

CAS: 31282-04-9

• Formula: C₂₀H₃₃D₄N₃O₁₃
• Color and Shape: Neat
• Molecular weight: 531.54

Hygromycin B - min 90%

CAS: 31282-04-9

Inhibitor of protein synthesis; aminoglycoside

• Formula: C₂₀H₃₇N₃O₁₃
• Purity: Min. 90 Area-%
• Color and Shape: Powder
• Molecular weight: 527.52 g/mol

Hygromycin B

CAS: 31282-04-9

Hygromycin B binds near the A site of 16S rRNA and induces errors in the …

• Formula: C₂₀H₃₇N₃O₁₃
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 527.52 g/mol

Hygromycin B

CAS: 31282-04-9

Applications Hygromycin B is an aminoglycoside and a selective antibiotic agent for the hph gene. …

• Formula: C₂₀H₃₇N₃O₁₃
• Color and Shape: Off-White
• Molecular weight: 527.52

Hygromycin B (HGR) for tissue culture, 90%

CAS: 31282-04-9

• Formula: C₂₀H₃₇N₃O₁₃
• Purity: min. 90%
• Color and Shape: White to off white, Powder
• Molecular weight: 527.52

Hygromycin B (HGR), 90%

CAS: 31282-04-9

• Formula: C₂₀H₃₇N₃O₁₃
• Purity: min. 90%
• Color and Shape: White to off - white, Powder
• Molecular weight: 527.52

Hygromycin B (HGR Solution), 50mg/ml in Aq. Solution

CAS: 31282-04-9

• Formula: C₂₀H₃₇N₃O₁₃
• Color and Shape: Light yellow to very dark yellow to brown-yellow or light orange to very dark orange, Liquid, Clear to slight hazy
• Molecular weight: 527.52