CAS 31282-04-9

Hygromycin B

Description:

Hygromycin B is an aminoglycoside antibiotic produced by the bacterium *Micromonospora hygroscopicus*. It is primarily known for its ability to inhibit protein synthesis in bacteria and some eukaryotic cells, making it a valuable tool in molecular biology for selecting genetically modified organisms. Hygromycin B is effective against a broad spectrum of microorganisms, including certain Gram-positive and Gram-negative bacteria, as well as fungi. Its mechanism of action involves binding to the ribosomal RNA, disrupting the translation process. The compound is typically used in laboratory settings for the selection of cells that have been transformed with hygromycin resistance genes. Hygromycin B is soluble in water and exhibits stability under various pH conditions, although it is sensitive to light and should be stored in a dark environment. Safety precautions are necessary when handling this compound, as it can be toxic to humans and other organisms at high concentrations. Overall, Hygromycin B is a crucial reagent in genetic engineering and cell biology research.

Formula: C₂₀H₃₇N₃O₁₃

InChI: InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20?/m1/s1

InChI key: InChIKey=GRRNUXAQVGOGFE-HUCHGKBZSA-N

SMILES: O[C@H]1C2(O[C@]3([C@@](O2)([C@@H](O)[C@@H](CO)O[C@H]3O[C@H]4[C@H](O)[C@@H](NC)C[C@@H](N)[C@@H]4O)[H])[H])O[C@]([C@H](CO)N)([C@H](O)[C@@H]1O)[H]

Synonyms:

• (3'R,3aS,4S,4'R,5'R,6R,6'R,7S,7aS)-4-{[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)octahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-3',4',5',7-tetrol (non-preferred name)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-<smallcap>L</smallcap>-glycero-<smallcap>D</smallcap>-galacto-heptopyranosylidene-(1→2-3)-O-β-<smallcap>D</span>-talopyranosyl-(1→5)-2-deoxy-N³-methyl-
• Antihelmycin
• Hygromix 2.4
• Hygromix-8
• Hygromycin B
• Hygromycin B - Solution
• Hygromycin B Streptomyces hygroscopicus
• Hygromycin B solution Streptomyces hygroscopicus
• Hygrovetin
• Hygrovetine
• O-6-Amino-6-deoxy-<span class="text-smallcaps">L</smallcap>-glycero-<smallcap>D</smallcap>-galacto-heptopyranosylidene-(1→2-3)-O-β-<smallcap>D</smallcap>-talopyranosyl-(1→5)-2-deoxy-N³-methyl-<smallcap>D</span>-streptamine
• hygromycin B aqueous solution
• hygromycin B from streptomyces*hygroscopicus
• hygromycin B plant cell culture tested
• D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1→2-3)-O-β-D-talopyranosyl-(1→5)-2-deoxy-N3-methyl-

Hygromycin B

CAS: 31282-04-9

Formula: C₂₀H₃₇N₃O₁₃

Purity: >90.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 527.52

Ref: 3B-H1509

Hygromycin B

CAS: 31282-04-9

Hygromycin B, 31282-04-9, is an aminoglycoside antibiotic which exhibits activity against eukaryotic and prokaryotic cells through inhibition of protein synthesis. Learn more.

Formula: C₂₀H₃₇N₃O₁₃

Color and Shape: Cream to plale brown, Powder

Molecular weight: 527.52

Ref: 02-J60681

Hygromycin B, 50 mg/ml in distilled water, sterile-filtered

CAS: 31282-04-9

Hygromycin B, 50mg/mL in distilled water, sterile-filtered

Formula: C₂₀H₃₇N₃O₁₃

Color and Shape: Liquid, Pale yellow to brown

Molecular weight: 527.52

Ref: 02-J67371

Hygromycin B, PBS solution, 1 pack = 20ml

CAS: 31282-04-9

Hygromycin B, PBS solution, 1 pack = 20ml

Formula: C₂₀H₃₇N₃O₁₃

Purity: ≥95%

Color and Shape: Liquid

Molecular weight: 527.52008

Ref: 54-BIH0125

Hygromycin B, powder

CAS: 31282-04-9

Hygromycin B, powder

Formula: C₂₀H₃₇N₃O₁₃

Purity: By hplc: 99.4% (Typical Value in Batch COA)

Color and Shape: Beige Solid-Powder

Molecular weight: 527.52008

Ref: 54-BIH4302

Hygromycin B

CAS: 31282-04-9

Hygromycin B disrupts protein synthesis in 70S ribosomes, used as an anthelmintic in swine.

Formula: C₂₀H₃₇N₃O₁₃

Purity: 98% - 99.95%

Color and Shape: White Solid

Molecular weight: 527.52

Ref: TM-T1022

Hygromycin B

CAS: 31282-04-9

Hygromycin B

Formula: C₂₀H₃₇N₃O₁₃

Purity: 99.5%

Color and Shape: Solid

Molecular weight: 527.52

Ref: 54-BUP17695

Hygromycin B

CAS: 31282-04-9

Formula: C₂₀H₃₇N₃O₁₃

Purity: ≥ 90.0%

Color and Shape: White to beige powder

Molecular weight: 527.53

Ref: 7W-GA7834

Hygromycin B

Controlled Product

CAS: 31282-04-9

Formula: C₂₀H₃₇N₃O₁₃

Color and Shape: Neat

Molecular weight: 527.52

Ref: 04-C14260000

Hygromycin B (Standard)

CAS: 31282-04-9

Hygromycin B (Standard) is the standard substance of Hygromycin B, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hygromycin B (Hygrovetine) is an aminoglycoside antibiotic that inhibits protein synthesis in both prokaryotic and eukaryotic cells by interfering with translocation and causing mistranslation by the 70S ribosome. It is commonly used for the selection of cells transfected with the hph or hyg resistance gene.

Formula: C₂₀H₃₇N₃O₁₃

Color and Shape: Solid

Molecular weight: 527.52

Ref: TM-TMSM-1343

Hygromycin B

Controlled Product

CAS: 31282-04-9

Applications Hygromycin B is an aminoglycoside and a selective antibiotic agent for the hph gene. Hygromycin B inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cha, T.S., et al.: World. J. Microbiol. Biotechnol., 28, 1771 (2012); Herrero, L., et al.: Biochem., 52, 171 (2013);

Formula: C₂₀H₃₇N₃O₁₃

Color and Shape: Neat

Molecular weight: 527.52

Ref: TR-H997600

Hygromycin B Deuterated (d4 major)

Controlled Product

CAS: 31282-04-9

Formula: C₂₀H₃₃D₄N₃O₁₃

Color and Shape: Neat

Molecular weight: 531.54

Ref: TR-H997604

Hygromycin B

CAS: 31282-04-9

Formula: C₂₀H₃₇N₃O₁₃

Molecular weight: 527.52

Ref: 4Z-H-062002

Hygromycin B - min 90%

CAS: 31282-04-9

Inhibitor of protein synthesis; aminoglycoside

Formula: C₂₀H₃₇N₃O₁₃

Purity: Min. 90 Area-%

Color and Shape: Powder

Molecular weight: 527.52 g/mol

Ref: 3D-AH159881

Hygromycin B

CAS: 31282-04-9

Hygromycin B binds near the A site of 16S rRNA and induces errors in the code by inhibition of translocation of peptydil-tRNA, however to a lesser extent compared to other aminoglycosides. Hygromycin B is efficient against bacteria, fungi and other eukaryotic cells, but more often used for the selection of eukaryotic cells including yeasts, such as, P. pastoris and S. cerevisiae, and mammalian cell lines, such as, CHO.

Formula: C₂₀H₃₇N₃O₁₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 527.52 g/mol

Ref: 3D-AH11348

Hygromycin B

CAS: 31282-04-9

Formula: C₂₀H₃₇N₃O₁₃

Color and Shape: Amorphous solid or tan powder. (NTP, 1992)

Molecular weight: 527.5

Ref: BE-RMCH082002

Hygromycin B

CAS: 31282-04-9

Formula: C₂₀H₃₇N₃O₁₃

Color and Shape: Amorphous solid or tan powder. (NTP, 1992)

Molecular weight: 527.5

Ref: BE-BePure-23468

Hygromycin B

CAS: 31282-04-9

(3aS,3'R,4S,4'S,5'R,6R,6'R,7S,7aS)-4-(((1R,2S,3R,5S,6R)-3-Amino-2,6-dihydroxy-5-(methylamino)cyclohexyl)oxy)-6'-((S)-1-amino-2-hydroxyethyl)-6-(hydroxymethyl)octahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2'-pyran]-3',4',5',7-tetraol

Formula: C₂₀H₃₇N₃O₁₃

Purity: ≥950U/mg

Molecular weight: 527.52

Ref: IN-DG134243

Hygromycin B

CAS: 31282-04-9

Formula: C₂₀H₃₇N₃O₁₃

Molecular weight: 527.52

Ref: ST-EA-CP-H48000

Hygromycin B (HGR), 90%

CAS: 31282-04-9

Formula: C₂₀H₃₇N₃O₁₃

Purity: min. 90%

Color and Shape: White to off - white, Powder

Molecular weight: 527.52

Ref: SR-67317