CAS 319460-85-0: Axitinib

Description: Axitinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of advanced renal cell carcinoma. It selectively inhibits vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3), which play a crucial role in tumor angiogenesis and growth. The chemical formula of Axitinib is C19H18N4O4, and it has a molecular weight of approximately 358.37 g/mol. This compound is characterized by its ability to interfere with the signaling pathways that promote blood vessel formation in tumors, thereby inhibiting tumor growth and metastasis. Axitinib is administered orally and is known for its relatively high bioavailability. Its pharmacokinetics include a moderate half-life, necessitating careful dosing to maintain therapeutic levels. Common side effects may include hypertension, fatigue, and gastrointestinal disturbances. Due to its mechanism of action, Axitinib is classified as an antineoplastic agent and is often used in combination with other therapies to enhance treatment efficacy in cancer patients.

Formula: C₂₂H₁₈N₄OS

InChI: InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+

InChI key: InChIKey=RITAVMQDGBJQJZ-FMIVXFBMSA-N

SMILES: O=C(NC)C=1C=CC=CC1SC=2C=CC=3C(=NNC3C2)C=CC4=NC=CC=C4

Synonyms:

• Ag 013736
• Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-
• Inlyta
• N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
• N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide
• N-methyl-2-({3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
• Axitinib

Axitinib

CAS: 319460-85-0

• Formula: C₂₂H₁₈N₄OS
• Purity: >95.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 386.47

(E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

CAS: 319460-85-0

• Formula: C₂₂H₁₈N₄OS
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 386.4695

Axitinib

CAS: 319460-85-0

Axitinib (AG-013736) is a multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1/2/3 and PDGFRβ. Axitinib has …

• Formula: C₂₂H₁₈N₄OS
• Purity: 98.9% - 99.81%
• Color and Shape: Off-White Solid
• Molecular weight: 386.47

Axitinib

CAS: 319460-85-0

• Purity: 98%
• Molecular weight: 386.47g/mol

Axitinib

CAS: 319460-85-0

• Formula: C₂₂H₁₈N₄OS
• Purity: ≥ 98.0%
• Color and Shape: White to off-white powder
• Molecular weight: 386.47

Axitinib

CAS: 319460-85-0

• Purity: 99.52%
• Molecular weight: 386.47g/mol

Axitinib

CAS: 319460-85-0

• Formula: C₂₂H₁₈N₄OS
• Color and Shape: Off-White Solid
• Molecular weight: 386.47

Axitinib

CAS: 319460-85-0

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₂₂H₁₈N₄OS
• Color and Shape: Crystalline powder, Almost white to yellow
• Molecular weight: 386.47

Axitinib

CAS: 319460-85-0

• Formula: C₂₂H₁₈N₄OS
• Color and Shape: Neat
• Molecular weight: 386.47

Axitinib

CAS: 319460-85-0

Inhibits VEGFR1, VEGFR2, VEGFR3, c-kit and PDGFR tyrosine kinases

• Formula: C₂₂H₁₈N₄OS
• Purity: Min. 98 Area-%
• Color and Shape: White Yellow Powder
• Molecular weight: 386.47 g/mol

N-methyl-2-[[3-[(1E)-2-(pyridinyl) ethenyl]-[N-[(5hydroxy methyl furanyl)-hydroxymethyl]-1H-indazol-6-yl-thiol]]-benzamide

CAS: 319460-85-0

• Formula: C₂₈H₂₄N₄O₄S
• Color and Shape: Neat
• Molecular weight: 512.58

Axitinib

CAS: 319460-85-0

• Formula: C₂₂H₁₈N₄OS
• Color and Shape: Off-White To Beige
• Molecular weight: 386.47