CAS 319460-85-0

Axitinib

Description:

Axitinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of advanced renal cell carcinoma. It selectively inhibits vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3), which play a crucial role in tumor angiogenesis and growth. The chemical formula of Axitinib is C19H18N4O4, and it has a molecular weight of approximately 358.37 g/mol. This compound is characterized by its ability to interfere with the signaling pathways that promote blood vessel formation in tumors, thereby inhibiting tumor growth and metastasis. Axitinib is administered orally and is known for its relatively high bioavailability. Its pharmacokinetics include a moderate half-life, necessitating careful dosing to maintain therapeutic levels. Common side effects may include hypertension, fatigue, and gastrointestinal disturbances. Due to its mechanism of action, Axitinib is classified as an antineoplastic agent and is often used in combination with other therapies to enhance treatment efficacy in cancer patients.

Formula: C₂₂H₁₈N₄OS

InChI: InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+

InChI key: InChIKey=RITAVMQDGBJQJZ-FMIVXFBMSA-N

SMILES: C(=C/C1=CC=CC=N1)\C=2C=3C(=CC(SC4=C(C(NC)=O)C=CC=C4)=CC3)NN2

Synonyms:

• Ag 013736
• Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-
• Inlyta
• N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
• N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide
• N-methyl-2-({3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
• Axitinib

Axitinib

CAS: 319460-85-0

Formula: C₂₂H₁₈N₄OS

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 386.47

Ref: 3B-A3479

(E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

CAS: 319460-85-0

Formula: C₂₂H₁₈N₄OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 386.4695

Ref: IN-DA0037NX

Axitinib

CAS: 319460-85-0

Axitinib (AG-013736) is a multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1/2/3 and PDGFRβ. Axitinib has antitumor activity. Cost-effective and quality-assured.

Formula: C₂₂H₁₈N₄OS

Purity: 98.9% - 99.74%

Color and Shape: Off-White Solid

Molecular weight: 386.47

Ref: TM-T1452

Axitinib

CAS: 319460-85-0

Axitinib

Purity: 98%

Molecular weight: 386.47g/mol

Ref: 54-OR1027894

Axitinib

CAS: 319460-85-0

Formula: C₂₂H₁₈N₄OS

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 386.47

Ref: 7W-GP9798

Axitinib

CAS: 319460-85-0

Axitinib

Purity: ≥98%

Molecular weight: 386.47g/mol

Ref: 54-BUP17829

Axitinib

CAS: 319460-85-0

Formula: C₂₂H₁₈N₄OS

Color and Shape: Off-White Solid

Molecular weight: 386.47

Ref: 4Z-A-188008

Axitinib

CAS: 319460-85-0

Color and Shape: Neat

Ref: 86-MM3922.00

Axitinib

Controlled Product

CAS: 319460-85-0

Formula: C₂₂H₁₈N₄OS

Color and Shape: Off-White To Beige

Molecular weight: 386.47

Ref: TR-A794650

Axitinib

CAS: 319460-85-0

Inhibits VEGFR1, VEGFR2, VEGFR3, c-kit and PDGFR tyrosine kinases

Formula: C₂₂H₁₈N₄OS

Purity: Min. 98 Area-%

Color and Shape: White Yellow Powder

Molecular weight: 386.47 g/mol

Ref: 3D-FA18036

N-methyl-2-[[3-[(1E)-2-(pyridinyl) ethenyl]-[N-[(5hydroxy methyl furanyl)-hydroxymethyl]-1H-indazol-6-yl-thiol]]-benzamide

Controlled Product

CAS: 319460-85-0

Formula: C₂₈H₂₄N₄O₄S

Color and Shape: Neat

Molecular weight: 512.58

Ref: TR-M330435