CAS 32854-75-4: Lappaconitine

Description: Lappaconitine is a naturally occurring alkaloid derived from various species of the Aconitum plant, commonly known as monkshood or wolfsbane. It is characterized by its complex bicyclic structure, which includes a nitrogen atom in its ring system, contributing to its pharmacological properties. Lappaconitine exhibits analgesic and anti-inflammatory effects, making it of interest in medicinal chemistry. It acts primarily on the central nervous system, where it can influence pain pathways. The compound is known for its potential toxicity, as many Aconitum species contain other toxic alkaloids, necessitating careful handling and dosage considerations. Lappaconitine's solubility is generally low in water but may vary in organic solvents, which is important for its extraction and formulation in pharmaceutical applications. Additionally, its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for understanding its therapeutic potential and safety profile. Overall, Lappaconitine represents a significant area of research in natural product chemistry and pharmacology, with ongoing studies exploring its mechanisms of action and potential therapeutic uses.

Formula: C₃₂H₄₄N₂O₈

InChI: InChI=1S/C32H44N2O8/c1-6-34-16-29(42-28(36)18-9-7-8-10-21(18)33-17(2)35)12-11-25(40-4)31-23(29)14-20(26(31)34)30(37)15-22(39-3)19-13-24(31)32(30,38)27(19)41-5/h7-10,19-20,22-27,37-38H,6,11-16H2,1-5H3,(H,33,35)/t19-,20+,22+,23-,24+,25+,26-,27+,29-,30+,31+,32+/m1/s1

InChI key: InChIKey=NWBWCXBPKTTZNQ-QOQRDJBUSA-N

SMILES: O=C(OC12CN(CC)C3C4CC1C3(C(OC)CC2)C5CC6C(OC)CC4(O)C5(O)C6OC)C=7C=CC=CC7NC(=O)C

Synonyms:

• (14Alpha,16Beta)-20-Ethyl-8,9-Dihydroxy-1,14,16-Trimethoxyaconitan-4-Yl 2-(Acetylamino)Benzoate
• (1A,14A,16B)-20-Ethyl-1,14,16-Trimethoxyaconitane-4,8,9-Triol 4-(2-Acetylamino)Benzoate)
• (1Alpha,10Alpha,13Alpha,14Alpha,16Beta,17Xi)-20-Ethyl-8,9-Dihydroxy-1,14,16-Trimethoxyaconitan-4-Yl 2-(Acetylamino)Benzoate
• 2H-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-4,8,9-triol deriv.
• Acetyl-10-deoxysepaconitine
• Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-, 4-(2-acetylamino)benzoate), (1-alpha,14-alpha,16-beta)-
• Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-, 4-[2-(acetylamino)benzoate], (1α,14α,16β)-
• Brn 0072755
• Lannaconitine
• Lappaconitine
• 5-21-06-00291 (Beilstein Handbook Reference)

Lappaconitine Hydrobromide

CAS: 32854-75-497792-45-5

• Formula: C₃₂H₄₄N₂O₈·HBr
• Purity: >95.0%(N)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 665.62

Lappaconitine

CAS: 32854-75-4

Lappaconitine ((+)-Lappaconitine), isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.

• Formula: C₃₂H₄₄N₂O₈
• Purity: 99.68%
• Color and Shape: White Powder
• Molecular weight: 584.7

Lappaconitine

CAS: 32854-75-4

• Formula: C₃₂H₄₄N₂O₈
• Molecular weight: 584.70

Lappaconitine

CAS: 32854-75-4

• Formula: C₃₂H₄₄N₂O₈
• Color and Shape: White To Off-White Solid
• Molecular weight: 584.71

Lappaconitine

CAS: 32854-75-4

• Formula: C₃₂H₄₄N₂O₈
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 584.71

Lappaconitine

CAS: 32854-75-4

• Formula: C₃₂H₄₅N₂O₈
• Purity: 95%~99%
• Molecular weight: 585.718

Lappaconitine

CAS: 32854-75-4

Traditionally used for pain relief, lappaconitine is a plant-derived C18-diterpenoid alkaloid. The molecular structure of …

• Formula: C₃₂H₄₄N₂O₈
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 584.7 g/mol

(+)-Lappaconitine >90%

CAS: 32854-75-4

Stability Hygroscopic Applications (+)-Lappaconitine is a potential antitumor agent agent that induces HL-60 differentiation and …

• Formula: C₃₂H₄₄N₂O₈
• Purity: >90%
• Color and Shape: Neat
• Molecular weight: 584.70