CAS 32854-75-4

Lappaconitine

Description:

Lappaconitine is a naturally occurring alkaloid derived from various species of the Aconitum plant, commonly known as monkshood or wolfsbane. It is characterized by its complex bicyclic structure, which includes a nitrogen atom in its ring system, contributing to its pharmacological properties. Lappaconitine exhibits analgesic and anti-inflammatory effects, making it of interest in medicinal chemistry. It acts primarily on the central nervous system, where it can influence pain pathways. The compound is known for its potential toxicity, as many Aconitum species contain other toxic alkaloids, necessitating careful handling and dosage considerations. Lappaconitine's solubility is generally low in water but may vary in organic solvents, which is important for its extraction and formulation in pharmaceutical applications. Additionally, its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for understanding its therapeutic potential and safety profile. Overall, Lappaconitine represents a significant area of research in natural product chemistry and pharmacology, with ongoing studies exploring its mechanisms of action and potential therapeutic uses.

Formula: C₃₂H₄₄N₂O₈

InChI: InChI=1S/C32H44N2O8/c1-6-34-16-29(42-28(36)18-9-7-8-10-21(18)33-17(2)35)12-11-25(40-4)31-23(29)14-20(26(31)34)30(37)15-22(39-3)19-13-24(31)32(30,38)27(19)41-5/h7-10,19-20,22-27,37-38H,6,11-16H2,1-5H3,(H,33,35)/t19-,20+,22+,23-,24+,25+,26-,27+,29-,30+,31+,32+/m1/s1

InChI key: InChIKey=NWBWCXBPKTTZNQ-QOQRDJBUSA-N

SMILES: O(C)[C@@H]1[C@@]23[C@]4([C@](OC(=O)C5=C(NC(C)=O)C=CC=C5)(CN(CC)[C@@]2([C@](C4)([C@]6(O)[C@]7(O)[C@]3(C[C@@]([C@@H]7OC)([C@@H](OC)C6)[H])[H])[H])[H])CC1)[H]

Synonyms:

• (14Alpha,16Beta)-20-Ethyl-8,9-Dihydroxy-1,14,16-Trimethoxyaconitan-4-Yl 2-(Acetylamino)Benzoate
• (1A,14A,16B)-20-Ethyl-1,14,16-Trimethoxyaconitane-4,8,9-Triol 4-(2-Acetylamino)Benzoate)
• (1Alpha,10Alpha,13Alpha,14Alpha,16Beta,17Xi)-20-Ethyl-8,9-Dihydroxy-1,14,16-Trimethoxyaconitan-4-Yl 2-(Acetylamino)Benzoate
• 2H-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-4,8,9-triol deriv.
• Acetyl-10-deoxysepaconitine
• Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-, 4-(2-acetylamino)benzoate), (1-alpha,14-alpha,16-beta)-
• Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-, 4-[2-(acetylamino)benzoate], (1α,14α,16β)-
• Brn 0072755
• Lannaconitine
• Lappaconitine
• 5-21-06-00291 (Beilstein Handbook Reference)

Lappaconitine Hydrobromide

CAS: 32854-75-4, 97792-45-5

Formula: C₃₂H₄₄N₂O₈·HBr

Purity: >95.0%(N)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 665.62

Ref: 3B-L0272

Lappaconitine

CAS: 32854-75-4

Lappaconitine ((+)-Lappaconitine), isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.

Formula: C₃₂H₄₄N₂O₈

Purity: 99.68%

Color and Shape: White Powder

Molecular weight: 584.7

Ref: TM-T2806

Lappaconitine

CAS: 32854-75-4

Formula: C₃₂H₄₄N₂O₈

Molecular weight: 584.70

Ref: 7W-GP3479

Lappaconitine

CAS: 32854-75-4

Formula: C₃₂H₄₄N₂O₈

Color and Shape: White To Off-White Solid

Molecular weight: 584.71

Ref: 4Z-L-130001

Lappaconitine

CAS: 32854-75-4

Formula: C₃₂H₄₄N₂O₈

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 584.71

Ref: 3B-L0442

Lappaconitine

CAS: 32854-75-4

Formula: C₃₂H₄₅N₂O₈

Purity: 95%~99%

Molecular weight: 585.718

Ref: BP-BP0842

Lappaconitine

Controlled Product

CAS: 32854-75-4

Traditionally used for pain relief, lappaconitine is a plant-derived C18-diterpenoid alkaloid. The molecular structure of lappaconitine was first reported in 1895. In rats, the antinociceptive action of lappaconitine has been shown to be based on the enhanced expression of dynorphin A in the spinal microglia. Lappaconitine hydrobromide is clinically used to reduce swelling and inflammation while providing a local anesthetic effect.

Formula: C₃₂H₄₄N₂O₈

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 584.7 g/mol

Ref: 3D-FL74135

(+)-Lappaconitine >90%

Controlled Product

CAS: 32854-75-4

Stability Hygroscopic
Applications (+)-Lappaconitine is a potential antitumor agent agent that induces HL-60 differentiation and apoptosis with analgesic activity as well.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Xu, M. et al.: Lat. Am. J. Pharm., 32, 1433 (2013);

Formula: C₃₂H₄₄N₂O₈

Purity: >90%

Color and Shape: Neat

Molecular weight: 584.70

Ref: TR-L175850