CAS 366-70-1

Procarbazine hydrochloride

Description:

Procarbazine hydrochloride is a pharmaceutical compound primarily used as an antineoplastic agent in the treatment of certain types of cancer, particularly Hodgkin's lymphoma and brain tumors. It is classified as a monoamine oxidase inhibitor (MAOI) and has a unique mechanism of action that involves the inhibition of DNA, RNA, and protein synthesis, which contributes to its cytotoxic effects on rapidly dividing cancer cells. The substance appears as a white to off-white crystalline powder and is soluble in water and alcohol. Procarbazine hydrochloride is typically administered orally and may be associated with various side effects, including myelosuppression, nausea, and potential interactions with other medications due to its MAOI properties. It is important for patients to follow specific dietary restrictions while on this medication to avoid hypertensive crises. As with any chemotherapy agent, careful monitoring and management by healthcare professionals are essential to ensure safety and efficacy during treatment.

Formula: C₁₂H₁₉N₃O·ClH

InChI: InChI=1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H

InChI key: InChIKey=DERJYEZSLHIUKF-UHFFFAOYSA-N

SMILES: C(NC(C)C)(=O)C1=CC=C(CNNC)C=C1.Cl

Synonyms:

• 1-Methyl-2-[p-(isopropylcarbamoyl)benzyl]hydrazine hydrochloride
• 2-[p-(Isopropylcarbamoyl)benzyl]-1-methylhydrazine hydrochloride
• 4-[(2-methylhydrazinyl)methyl]-N-(propan-2-yl)benzamide
• 4-[(2-methylhydrazinyl)methyl]-N-(propan-2-yl)benzamide hydrochloride (1:1)
• Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-, monohydrochloride
• Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazinyl)methyl]-, hydrochloride (1:1)
• Ibenzmethyzin hydrochloride
• Ibenzmethyzine hydrochloride
• Indicarb
• MIH hydrochloride
• Matulane
• N-Isopropyl-p-(2-methylhydrazinomethyl)benzamide hydrochloride
• N-Isopropyl-α-(2-methylhydrazino)-p-toluamide hydrochloride
• NSC 77213
• Nathulane
• Natulan
• Natulan hydrochloride
• Natulanar
• Nci-C 01810
• PCB hydrochloride
• Procarbazine HCL
• Ro 4 6467/1
• Ro 4-6467

Procarbazine HCl

CAS: 366-70-1

N-Isopropyl-4-((2-methylhydrazinyl)methyl)benzamide hydrochloride

Formula: C₁₂H₂₀ClN₃O

Purity: 98%

Molecular weight: 257.76

Ref: IN-DG149099

Procarbazine Hydrochloride

CAS: 366-70-1, 671-16-9

Formula: C₁₂H₁₉N₃O·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 257.76

Ref: 3B-P2550

PROCARBAZINE HYDROCHLORIDE RS

CAS: 366-70-1

PROCARBAZINE HYDROCHLORIDE RS

Formula: C₁₂H₁₉N₃O

Color and Shape: Powder

Molecular weight: 221.2988

Ref: 41-ICRS0399

Procarbazine Hydrochloride

CAS: 366-70-1

Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Formula: C₁₂H₁₉N₃O·HCI

Color and Shape: White Off-White Powder

Molecular weight: 361.06511

Ref: 45-1565009

Procarbazine hydrochloride

CAS: 366-70-1

Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities.

Formula: C₁₂H₁₉N₃O·HCl

Purity: 96.99% - 98.26%

Color and Shape: Solid

Molecular weight: 257.76

Ref: TM-T1488

Procarbazine Hydrochloride

CAS: 366-70-1

Procarbazine Hydrochloride

Formula: C₁₂H₂₀ClN₃O

Purity: 98%

Molecular weight: 257.76

Ref: 54-OR1029552

Procarbazine hydrochloride

CAS: 366-70-1

Procarbazine hydrochloride

Formula: C₁₂H₁₉N₃O·HCl

Purity: ≥80%

Molecular weight: 257.76

Ref: 54-BUP14909

Procarbazine HCl

CAS: 366-70-1

Formula: C₁₂H₁₉N₃O·HCl

Molecular weight: 221.30 36.46

Ref: 4Z-P-309001

Procarbazine Hydrochloride

Controlled Product

CAS: 366-70-1

Formula: C₁₂H₁₉N₃O·ClH

Color and Shape: Neat

Molecular weight: 257.76

Ref: 86-MM3239.00

Procarbazine hydrochloride

CAS: 366-70-1

Formula: C₁₂H₁₉N₃O·HCl

Purity: 98.0 - 102.0 % (dried basis)

Color and Shape: White to off-white powder

Molecular weight: 257.76

Ref: 7W-GP0917

Procarbazine Hydrochloride

Controlled Product

CAS: 366-70-1

Applications Antineoplastic.
References Rucki, R.J., et al.: Anal. Profiles Drug Subs., 5, 403 (1976), Massound, M., et al.: Eur. J. Cancer, 40, 1924 (2004),

Formula: C₁₂H₁₉N₃O·ClH

Color and Shape: Neat

Molecular weight: 257.76

Ref: TR-P755400

Procarbazine HCl - Bio-X ™

CAS: 366-70-1

Procarbazine is an alkylating agent used in chemotherapy to treat brain cancer and Hodgkin's lymphoma. It methylates guanine in DNA which causes the strands to become prone to breakage, thus inhibiting both DNA and RNA synthesis. The drug has been shown to be effective in vitro against a variety of human carcinoma cell lines.

Formula: C₁₂H₂₀ClN₃O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 257.76 g/mol

Ref: 3D-BP164298

Procarbazine hydrochloride

CAS: 366-70-1

Anti-cancer alkylating agent; inhibits protein, RNA and DNA synthesis

Formula: C₁₂H₁₉N₃O•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 257.76 g/mol

Ref: 3D-FP27166

4-[(2-methylhydrazin-1-yl)methyl]-N-(propan-2-yl)benzamide hydrochloride

CAS: 366-70-1

Formula: C₁₂H₂₀ClN₃O

Purity: 98%

Molecular weight: 257.76

Ref: 10-F358114

Procarbazine Hydrochloride

CAS: 366-70-1

Formula: C₁₂H₁₉N₃OHCl

Molecular weight: 221.30 : 36.46

Ref: ST-EA-CP-P298000