CAS 402960-38-7

2-Aminopyrimidine-5-boronic acid pinacol ester

Description:

2-Aminopyrimidine-5-boronic acid pinacol ester is a chemical compound characterized by its boronic acid functionality, which is known for its ability to form reversible covalent bonds with diols and is often utilized in various organic synthesis applications. This compound features a pyrimidine ring, which contributes to its aromatic properties and potential biological activity. The presence of the amino group enhances its reactivity and solubility in polar solvents, making it suitable for various chemical reactions, including Suzuki coupling reactions, which are pivotal in the formation of carbon-carbon bonds. The pinacol ester moiety provides stability and can facilitate the handling and storage of the boronic acid derivative. This compound is of interest in medicinal chemistry and materials science due to its potential applications in drug development and the synthesis of complex organic molecules. As with many boronic acids, it may exhibit sensitivity to moisture and air, necessitating careful storage conditions to maintain its integrity and reactivity.

Formula: C₁₀H₁₆BN₃O₂

InChI: InChI:1S/C10H16BN3O2/c1-9(2)10(3,4)16-11(15-9)7-5-13-8(12)14-6-7/h5-6H,1-4H3,(H2,12,13,14)

Synonyms:

• 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine
• 5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine
• 2-Aminopyrimidine-5-Boronic Acid, Pinacol Ester

2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

CAS: 402960-38-7

Formula: C₁₀H₁₆BN₃O₂

Purity: >98.0%(GC)(T)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 221.07

Ref: 3B-A3087

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

CAS: 402960-38-7

Formula: C₁₀H₁₆BN₃O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 221.0639

Ref: IN-DA0073P4

2-Aminopyrimidine-5-boronic acid, pinacol ester

CAS: 402960-38-7

2-Aminopyrimidine-5-boronic acid, pinacol ester

Formula: C₁₀H₁₆BN₃O₂

Purity: 98%

Color and Shape: tan solid

Molecular weight: 221.06g/mol

Ref: 54-OR59880

2-Aminopyrimidine-5-boronic acid pinacol ester

CAS: 402960-38-7

Purity: 98%

Molecular weight: 221.07

Ref: FT-A2103

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-pyrimidin-2-amine

CAS: 402960-38-7

Formula: C₁₀H₁₆BN₃O₂

Purity: 95%

Color and Shape: Solid, Light brown needles

Molecular weight: 221.07

Ref: 10-F064470

2-Aminopyrimidine-5-boronic Acid Pinacol Ester

Controlled Product

CAS: 402960-38-7

Applications 2-Aminopyrimidine-5-boronic Acid Pinacol Ester is used in the preparation of phosphoinositide-3-kinases (PI3K) inhibitors.
References Burger, M.T. et al.: ACS Med. Chem. Lett., 2, 774 (2011); Heffron, T.P. et al.: J. Med. Chdem., 55, 8007 (2012);

Formula: C₁₀H₁₆BN₃O₂

Color and Shape: Neat

Molecular weight: 221.06

Ref: TR-A629055

2-Aminopyrimidine-5-boronic acid pinacol ester

CAS: 402960-38-7

2-Aminopyrimidine-5-boronic acid pinacol ester is a boronic acid derivative that has been shown to inhibit the activity of protein kinase C. This compound is also an effective linker for cross-coupling reactions and has a low reactivity with nucleophiles, which makes it safer than other boronic acids. 2-Aminopyrimidine-5-boronic acid pinacol ester has been shown to be potent against cancer cells in vitro and in vivo and synthetic cells. 2-Aminopyrimidine-5-boronic acid pinacol ester inhibits the growth of cancer cells by binding to the ATP site on protein kinase C, thereby inhibiting its function.

Formula: C₁₀H₁₆BN₃O₂

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 221.06 g/mol

Ref: 3D-FA33574