CAS 404844-02-6

N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4-(piperazin-1-ylmethyl)benzamide

Description:

N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4-(piperazin-1-ylmethyl)benzamide is a complex organic compound characterized by its multi-functional structure, which includes a benzamide core, a piperazine moiety, and a pyrimidine-pyridine linkage. This compound typically exhibits properties such as moderate to high solubility in polar solvents, which is common for many amide derivatives. Its molecular structure suggests potential biological activity, particularly in medicinal chemistry, where such compounds are often explored for their roles as enzyme inhibitors or receptor modulators. The presence of multiple aromatic rings may contribute to its ability to interact with biological targets through π-π stacking and hydrogen bonding. Additionally, the piperazine ring can enhance the compound's pharmacokinetic properties, such as absorption and distribution. Overall, this compound's unique structural features make it a candidate for further research in drug development and therapeutic applications.

Formula: C₂₈H₂₉N₇O

InChI: InChI=1/C28H29N7O/c1-20-4-9-24(17-26(20)34-28-31-12-10-25(33-28)23-3-2-11-30-18-23)32-27(36)22-7-5-21(6-8-22)19-35-15-13-29-14-16-35/h2-12,17-18,29H,13-16,19H2,1H3,(H,32,36)(H,31,33,34)

SMILES: Cc1ccc(cc1Nc1nccc(c2cccnc2)n1)NC(=O)c1ccc(cc1)CN1CCNCC1

Synonyms:

• N-Desmethyl Imatinib
• N-Desmethyl gleevec

Imatinib impurity standard

CAS: 220127-57-1, 404844-02-6, 571186-93-1

Imatinib impurity standard

Color and Shape: Off-White

Ref: 47-1303

N-Desmethyl imatinib

CAS: 404844-02-6

N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.

Formula: C₂₈H₂₉N₇O

Purity: 98.60%

Color and Shape: Off-White To Pale-Yellow Solid

Molecular weight: 479.58

Ref: TM-T11641

N-Desmethyl Imatinib

CAS: 404844-02-6

Formula: C₂₈H₂₉N₇O

Purity: 90%

Color and Shape: Solid

Molecular weight: 479.5762

Ref: IN-DA0035DI

N-Desmethyl imatinib

CAS: 404844-02-6

N-Desmethyl imatinib

Purity: ≥95%

Molecular weight: 479.58g/mol

Ref: 54-BUP05121

N-(4-Methyl-3-((4-(Pyridin-3-Yl)Pyrimidin-2-Yl)Amino)Phenyl)-4-(Piperazin-1-Ylmethyl)Benzamide

CAS: 404844-02-6

N-(4-Methyl-3-((4-(Pyridin-3-Yl)Pyrimidin-2-Yl)Amino)Phenyl)-4-(Piperazin-1-Ylmethyl)Benzamide

Purity: 99%

Molecular weight: 479.58g/mol

Ref: 54-OR1024004

Imatinib EP Impurity C (N-Desmethyl Imatinib)

CAS: 404844-02-6

Formula: C₂₈H₂₉N₇O

Color and Shape: Pale Yellow Solid

Molecular weight: 479.59

Ref: 4Z-I-093

N-Desmethyl Imatinib

Controlled Product

CAS: 404844-02-6

Impurity Imatinib EP Impurity C
Applications N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.
References Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),

Formula: C₂₈H₂₉N₇O

Color and Shape: Neat

Molecular weight: 479.58

Ref: TR-D292045

Imatinib EP Impurity C

CAS: 404844-02-6

Formula: C₂₈H₂₉N₇O

Molecular weight: 479.59

Ref: ST-EA-CP-I5073

N-Desmethyl imatinib

CAS: 404844-02-6

Purity: 98%

Molecular weight: 479.24

Ref: 10-F554444