CAS 404950-80-7

Panobinostat

Description:

Panobinostat is a hydroxamic acid derivative and a potent pan-inhibitor of histone deacetylases (HDACs), which play a crucial role in the regulation of gene expression through chromatin remodeling. It is primarily utilized in the treatment of multiple myeloma, particularly in patients who have received prior therapies. Panobinostat exhibits a unique mechanism of action by inducing hyperacetylation of histones and non-histone proteins, leading to the activation of tumor suppressor genes and the inhibition of oncogenes. This compound is typically administered in combination with other agents, such as proteasome inhibitors, to enhance its therapeutic efficacy. In terms of its physical properties, panobinostat is a white to off-white solid, soluble in organic solvents, and has a relatively low molecular weight. Its pharmacokinetics involve extensive metabolism, primarily via the liver, and it is excreted through both urine and feces. As with many HDAC inhibitors, panobinostat can have side effects, including gastrointestinal disturbances and hematological toxicities, necessitating careful monitoring during treatment.

Formula: C₂₁H₂₃N₃O₂

InChI: InChI=1/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+

InChI key: InChIKey=FPOHNWQLNRZRFC-ZHACJKMWSA-N

SMILES: C(CNCC1=CC=C(/C=C/C(NO)=O)C=C1)C=2C=3C(NC2C)=CC=CC3

Synonyms:

• (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide
• (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide
• (E)-N-Hydroxy-3-(4-{[2-(2-Methyl-1H-Indol-3-Yl)-Ethylamino]-Methyl}-Phenyl)-Acrylamide
• 2-Propenamide, N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-
• Farydak
• Lbh-589
• N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide
• Nvp-Lbh-589
• Panobinostat
• panobinostat (HDAC inhibitor)
• LBH-589/Panobinostat
• Panobinostat (LBH589)
• NVP-LBH589

Panobinostat

CAS: 404950-80-7

Formula: C₂₁H₂₃N₃O₂

Purity: >93.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 349.43

Ref: 3B-P3137

(2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide

CAS: 404950-80-7

Formula: C₂₁H₂₃N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 349.4262

Ref: IN-DA0038RC

Panobinostat

CAS: 404950-80-7

(E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide

Formula: C₂₁H₂₃N₃O₂

Purity: 98%

Molecular weight: 349.43

Ref: IN-DG223959

Panobinostat

CAS: 404950-80-7

Panobinostat

Formula: C₂₁H₂₃N₃O₂

Purity: ≥95%

Color and Shape: Solid

Molecular weight: 349.43

Ref: 54-BUP17792

Panobinostat

CAS: 404950-80-7

Formula: C₂₁H₂₃N₃O₂

Molecular weight: 349.43

Ref: 4Z-P-841

Panobinostat

CAS: 404950-80-7

Panobinostat (NVP-LBH589) is a broad-spectrum HDAC inhibitor (IC50=5 nM) with oral activity and non-selectivity.

Formula: C₂₁H₂₃N₃O₂

Purity: 97.2% - 99.81%

Color and Shape: Solid

Molecular weight: 349.43

Ref: TM-T2383

Panobinostat-d8 (Major) Hydrochloride Salt

Controlled Product

CAS: 1185237-51-7, 404950-80-7

Applications The novel labelled histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells.
References Claus, R., et al.: Oncogene, 22, 6489 (2003), Johnstone, R., et al.: Cancer Cell., 4, 13 (2003), Ying, J., et al.: Clin. Cancer Res., 11, 6442 (2005), Catley, L., et al.: Blood, 108, 3441 (2006), Steinberg, M., et al.: Clin. Ther., 29, 2289 (2007),

Formula: C₂₁H₁₆D₈ClN₃O₂

Color and Shape: Neat

Molecular weight: 393.94

Ref: TR-P180502

Panobinostat(LBH-589)

Controlled Product

CAS: 404950-80-7

Applications The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Potent Histone deacetylase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Claus, R., et al.: Oncogene, 22, 6489 (2003), Johnstone, R., et al.: Cancer Cell., 4, 13 (2003), Ying, J., et al.: Clin. Cancer Res., 11, 6442 (2005), Catley, L., et al.: Blood, 108, 3441 (2006), Steinberg, M., et al.: Clin. Ther., 29, 2289 (2007),

Formula: C₂₁H₂₃N₃O₂

Color and Shape: Neat

Molecular weight: 349.43

Ref: TR-P180500

Panobinostat

CAS: 404950-80-7

Inhibitor of histone deacetylases

Formula: C₂₁H₂₃N₃O₂

Purity: Min. 97.5 Area-%

Color and Shape: Off-White Slightly Brown Yellow Powder

Molecular weight: 349.43 g/mol

Ref: 3D-FH26749

(E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide

CAS: 404950-80-7

Formula: C₂₁H₂₃N₃O₂

Purity: 98%

Color and Shape: Solid, White to off-white powder

Molecular weight: 349.434

Ref: 10-F091845

Panobinostat

CAS: 404950-80-7

Formula: C₂₁H₂₃N₃O₂

Molecular weight: 349.43

Ref: ST-EA-CP-P152000