CAS 42424-50-0

polyinosinic-polycytidylic acid sodium

Description:

Polyinosinic-polycytidylic acid sodium, commonly referred to as poly(I:C), is a synthetic double-stranded RNA molecule that serves as a potent immunostimulant. It is composed of alternating inosine and cytidine nucleotides, mimicking viral RNA, which triggers an immune response. Poly(I:C) is known to activate pattern recognition receptors, particularly Toll-like receptor 3 (TLR3), leading to the production of interferons and other cytokines that enhance antiviral defenses. This compound is often used in research and therapeutic applications, particularly in vaccine development and cancer immunotherapy, due to its ability to stimulate innate immunity. Poly(I:C) is typically administered in its sodium salt form, which enhances its solubility and stability in biological systems. Its characteristics include a high molecular weight, a negative charge due to the phosphate backbone, and the ability to form secondary structures that can influence its biological activity. Overall, poly(I:C) is a valuable tool in immunology and therapeutic research, providing insights into immune responses and potential treatment strategies.

Synonyms:

• Polyinosinic Acid . Polycytidylic Acid, Sodium Salt, Double
• Polyinosinic-Polycytidylic Acid Sodium Salt

Polyinosinic-polycytidylic acid sodium

CAS: 42424-50-0

Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and

Formula: (C₁₀H₁₃N₄O₈P)x·(C₉H₁₄N₃O₈P)x·xNa

Purity: 98%

Color and Shape: Solid

Molecular weight: 695.403

Ref: TM-T12516

Polyinosinic-polycytidylic acid sodium

CAS: 42424-50-0

Polyinosinic-polycytidylic acid sodium

Purity: ≥95%

Molecular weight: 695.403g/mol

Ref: 54-BUP08974

Polyinosinic Polycytidylic Acid Sodium Salt

CAS: 42424-50-0

Polyinosinic Polycytidylic Acid Sodium Salt

Ref: 54-OR1014786

Polyinosinic-polycytidylic acid sodium salt

CAS: 42424-50-0

Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure. PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations.  Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes. We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.
For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

Formula: (C₁₀H₁₃N₄O₈P)x•(C₉H₁₄N₃O₈P)x•Nax

Color and Shape: White Powder

Ref: 3D-TP36521