CAS 4291-63-8: Cladribine
Description:Cladribine is a synthetic purine nucleoside analog, primarily used in the treatment of certain types of leukemia and multiple sclerosis. Its chemical formula is C10H12ClN5O3, and it features a chlorinated adenine structure, which allows it to interfere with DNA synthesis and repair. Cladribine is characterized by its ability to selectively target lymphocytes, leading to a reduction in their proliferation and survival. This mechanism makes it effective in managing autoimmune conditions and hematological malignancies. The substance is typically administered intravenously or orally, and its pharmacokinetics involve rapid distribution and metabolism, with a relatively short half-life. Cladribine's side effects may include immunosuppression, which necessitates careful monitoring of patients during treatment. Additionally, it is classified as a hazardous substance, requiring appropriate handling and disposal measures in clinical settings. Overall, Cladribine represents a significant therapeutic option in oncology and neurology, demonstrating the importance of nucleoside analogs in modern medicine.
Formula:C10H12ClN5O3
InChI:InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
InChI key:InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N
SMILES:ClC=1N=C(N)C=2N=CN(C2N1)C3OC(CO)C(O)C3
- Synonyms:
- (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
- 2-CdA
- 2-Chloro-2'-deoxy-β-adenosine
- 2-Chloro-2'-deoxyadenosine
- 2-Chloro-6-amino-9-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)purine
- 2-Chloro-6-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine
- 2-Chlorodeoxyadenosine
- Biodribin
- Cladarabine
- Cladribine
- See more synonyms
- CldAdo
- Jk 6251
- Leustat
- Leustatin
- Litak
- Mavenclad
- Nsc 105014
- Nsc 105014-F
- Rwj 26251
- Vero-Cladribine
- Adenosine, 2-chloro-2′-deoxy-
