CAS 4291-63-8

Cladribine

Description:

Cladribine is a synthetic purine nucleoside analog, primarily used in the treatment of certain types of leukemia and multiple sclerosis. Its chemical formula is C10H12ClN5O3, and it features a chlorinated adenine structure, which allows it to interfere with DNA synthesis and repair. Cladribine is characterized by its ability to selectively target lymphocytes, leading to a reduction in their proliferation and survival. This mechanism makes it effective in managing autoimmune conditions and hematological malignancies. The substance is typically administered intravenously or orally, and its pharmacokinetics involve rapid distribution and metabolism, with a relatively short half-life. Cladribine's side effects may include immunosuppression, which necessitates careful monitoring of patients during treatment. Additionally, it is classified as a hazardous substance, requiring appropriate handling and disposal measures in clinical settings. Overall, Cladribine represents a significant therapeutic option in oncology and neurology, demonstrating the importance of nucleoside analogs in modern medicine.

Formula: C₁₀H₁₂ClN₅O₃

InChI: InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1

InChI key: InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N

SMILES: NC1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)C3)=NC(Cl)=N1

Synonyms:

• (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
• 2-CdA
• 2-Chloro-2'-deoxy-β-adenosine
• 2-Chloro-2'-deoxyadenosine
• 2-Chloro-6-amino-9-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)purine
• 2-Chloro-6-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine
• 2-Chlorodeoxyadenosine
• Biodribin
• Cladarabine
• Cladribine
• CldAdo
• Jk 6251
• Leustat
• Leustatin
• Litak
• Mavenclad
• Nsc 105014
• Nsc 105014-F
• Rwj 26251
• Vero-Cladribine

Cladribine

CAS: 4291-63-8

Formula: C₁₀H₁₂ClN₅O₃

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 285.69

Ref: 3B-C2499

CLADRIBINE CRS

CAS: 4291-63-8

CLADRIBINE CRS

Color and Shape: Added Modified

Ref: 41-Y0000639

CLADRIBINE FOR PEAK IDENTIFICATION CRS

CAS: 4291-63-8

CLADRIBINE FOR PEAK IDENTIFICATION CRS

Formula: C₁₀H₁₂ClN₅O₃

Molecular weight: 285.687

Ref: 41-Y0000609

Cladribine

CAS: 4291-63-8

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₀H₁₂ClN₅O₃

Color and Shape: White Off-White Powder

Molecular weight: 285.06287

Ref: 45-1134200

(2R,3S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol

CAS: 4291-63-8

Formula: C₁₀H₁₂ClN₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 285.6870

Ref: IN-DA003P0J

Cladribine-13C-15N2

CAS: 4291-63-8

Formula: C₉₁₃CH₁₂ClN₃₁₅N₂O₃

Molecular weight: 288.67

Ref: 4Z-C-160014

2-Chloro-2'-deoxyadenosine

CAS: 4291-63-8

2-Chloro-2'-deoxyadenosine

Formula: C₁₀H₁₂ClN₅O₃

Purity: By hplc: >99% (Typical Value in Batch COA)

Color and Shape: white to off white crystals

Molecular weight: 285.69g/mol

Ref: 54-BIMN2008

Cladribine

CAS: 4291-63-8

Cladribine

Purity: ≥98%

Molecular weight: 285.69g/mol

Ref: 54-BUP14487

Cladribine

CAS: 4291-63-8

Formula: C₁₀H₁₂ClN₅O₃

Purity: ≤ 0.1% (HPLC)

Color and Shape: White to off-white powder

Molecular weight: 285.69

Ref: 7W-GP2063

Cladribine

CAS: 4291-63-8

Formula: C₁₀H₁₂ClN₅O₃

Color and Shape: White To Off-White Solid

Molecular weight: 285.69

Ref: 4Z-C-160001

Cladribine

Controlled Product

CAS: 4291-63-8

Formula: C₁₀H₁₂ClN₅O₃

Color and Shape: Neat

Molecular weight: 285.69

Ref: 86-MM3381.00

Cladribine

CAS: 4291-63-8

Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.

Formula: C₁₀H₁₂ClN₅O₃

Purity: 99.58% - >99.99%

Color and Shape: White Crystalline Solid

Molecular weight: 285.69

Ref: TM-T2558

Cladribine-13C5

CAS: 4291-63-8

Formula: C₅₁₃C₅H₁₂ClN₅O₃

Molecular weight: 290.65

Ref: 4Z-C-160011

Cladribine

CAS: 4291-63-8

Applications It is a substituted purine nucleoside with antileukemic activity.
References Seto, S., et al.: J. Clin. Invest., 75, 377 (1985), Piro, L.D., et al.: N. Engl. J. Med., 322, 1117 (1990);

Formula: C₁₀H₁₂ClN₅O₃

Color and Shape: White To Light Yellow

Molecular weight: 285.69

Ref: TR-C557500

Cladribine - Bio-X ™

CAS: 4291-63-8

Cladribine is a purine nucleoside analogue that interferes with DNA synthesis by acting as a false building block in the DNA chain during replication. Cladribine is incorporated into the growing DNA chain, causing chain termination and leading to DNA damage, apoptosis (programmed cell death), and ultimately cell death. Cladribine is structurally similar to adenosine, but is partially resistant to breakdown by adenosine deaminase due to a chlorine molecule at position 2. This causes it to accumulate in cells and interfere with the targeted cell's ability to process DNA. This mechanism of action makes cladribine an effective treatment for certain types of cancer and autoimmune diseases, where it targets rapidly dividing cells.

Formula: C₁₀H₁₂ClN₅O₃

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 285.69 g/mol

Ref: 3D-BC164318

Cladribine

CAS: 4291-63-8

Deoxyadenosine analog resistant to adenosine deaminase

Formula: C₁₀H₁₂ClN₅O₃

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 285.69 g/mol

Ref: 3D-NC06337

2-Chloro-2′-deoxyadenosine

CAS: 4291-63-8

Formula: C₁₀H₁₂ClN₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 285.69

Ref: 10-F078689