CAS 432545-63-6

L-Glutamic acid,N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methyl-d3-amino]benzoyl]- (9CI)

Description:

L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methyl-d3-amino]benzoyl]- (9CI), with the CAS number 432545-63-6, is a synthetic compound that features a complex structure incorporating both amino acid and pteridine moieties. As a derivative of L-glutamic acid, it retains the characteristic carboxylic acid and amino functional groups, which contribute to its solubility in water and its role in biological systems. The presence of the pteridine ring suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific biological pathways. This compound may exhibit properties such as being a substrate or inhibitor in enzymatic reactions, and its structural modifications could influence its binding affinity and selectivity towards biological targets. Additionally, the incorporation of deuterium (d3) in its structure may enhance its stability and alter its metabolic profile. Overall, this compound represents a unique intersection of amino acid chemistry and heterocyclic compounds, making it of interest in both research and therapeutic contexts.

Formula: C₂₀H₁₉D₃N₈O₅

Synonyms:

• Methotrexate-D3

Methotrexate-d3

CAS: 432545-63-6

Methotrexate-d3 is a deuterated compound of Methotrexate.

Formula: C₂₀H₁₉D₃N₈O₅

Color and Shape: Solid

Molecular weight: 457.46

Ref: TM-TMIH-0335

Methotrexate-d3 Tetraglutamate Trifluoroacetate

CAS: 432545-63-6

Formula: C₃₅H₄₀D₃N₁₁O₁₄·(C₂HF₃O₂)n

Molecular weight: 844.80

Ref: 4Z-M-7025

Methotrexate-d3 Diglutamate Trifluoroacetate

CAS: 432545-63-6

Formula: C₂₅H₂₆D₃N₉O₈·(C₂HF₃O₂)n

Molecular weight: 586.57

Ref: 4Z-M-7021

Methotrexate-d3 Heptaglutamate Trifluoroacetate

CAS: 432545-63-6

Formula: C₅₀H₆₁D₃N₁₄O₂₃·C₂HF₃O₂

Molecular weight: 1232.14

Ref: 4Z-M-7027

Methotrexate-d3 Triglutamate Trifluoroacetate

CAS: 432545-63-6

Formula: C₃₀H₃₃D₃N₁₀O₁₁·(C₂HF₃O₂)m

Molecular weight: 715.69

Ref: 4Z-M-7023

Methotrexate-d3 Diglutamate Trifluoroacetate

Controlled Product

CAS: 41600-13-9, 432545-63-6

Applications Methotrexate-d3 Diglutamate is the isotope labelled analog of Methotrexate Diglutamate (M260720); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)

Formula: C₂₅H₂₆D₃N₉O₈•x(C₂HF₃O₂)•xH₂SO₄

Color and Shape: Neat

Molecular weight: 586.5811402981

Ref: TR-M260722

Methotrexate-d3 Tetraglutamate Trifluoroacetate

Controlled Product

CAS: 432545-63-6, 73610-81-8

Stability Hygroscopic
Applications Methotrexate-d3 Tetraglutamate is the isotope labelled analog of Methotrexate Tetraglutamate (M260730); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)

Formula: C₃₅H₄₀D₃N₁₁O₁₄•(C₂HF₃O₂)x

Color and Shape: Neat

Molecular weight: 844.8

Ref: TR-M260732

Methotrexate-d3

Controlled Product

CAS: 432545-63-6

Applications Labelled Methotrexate (M260675). A Folic acid antagonist. Used as a antineoplastic and antirheumatic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),

Formula: C₂₀H₁₉D₃N₈O₅

Color and Shape: Neat

Molecular weight: 457.46

Ref: TR-M260677

Methotrexate-d3 (Technical Grade) (100ug/mL in Methanol with 1% 0.1N NaOH)

Controlled Product

CAS: 432545-63-6

Formula: C₂₀H₁₉D₃N₈O₅

Color and Shape: Single Solution

Molecular weight: 457.46

Ref: TR-KIT0312

Methotrexate-d3 Pentaglutamate Trifluoroacetate (>90%)

Controlled Product

CAS: 432545-63-6, 80801-54-3

Applications Methotrexate-d3 Pentaglutamate is the isotope labelled analog of Methotrexate Pentaglutamate (M260735); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)

Formula: C₄₀H₄₇D₃N₁₂O₁₇(C₂HF₃O₂)x

Purity: >90%

Color and Shape: Neat

Molecular weight: 973.91

Ref: TR-M260737

Methotrexate-d3 Triglutamate Trifluoroacetate

Controlled Product

CAS: 41600-14-0, 432545-63-6

Stability Hygroscopic
Applications Methotrexate-d3 Triglutamate is the isotope labelled analog of Methotrexate Triglutamate (M260725); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)

Formula: C₃₀H₃₃D₃N₁₀O₁₁(C₂HF₃O₂)x

Color and Shape: Neat

Molecular weight: 715.69

Ref: TR-M260727

Methotrexate-d3 Heptaglutamate Trifluoroacetate

Controlled Product

CAS: 432545-63-6, 59-05-2

Formula: C₅₀H₆₁D₃N₁₄O₂₃xC₂HF₃O₂

Color and Shape: Neat

Molecular weight: 1232.142

Ref: TR-M260692