CAS 444731-52-6

Pazopanib

Description:

Pazopanib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of cancer, including renal cell carcinoma and soft tissue sarcoma. Its mechanism of action involves the inhibition of multiple receptor tyrosine kinases, which play a crucial role in tumor growth and angiogenesis. Chemically, pazopanib is characterized by its complex structure, which includes a pyrimidine ring and various functional groups that contribute to its pharmacological activity. It is typically administered orally and exhibits a moderate to high bioavailability. Pazopanib is known for its side effects, which can include hypertension, diarrhea, and liver enzyme elevations, necessitating regular monitoring during treatment. The substance is classified as a targeted therapy, reflecting its specificity for cancer cells while sparing normal cells to some extent. Its development has significantly impacted cancer treatment protocols, providing an important option for patients with advanced disease. Overall, pazopanib exemplifies the advancements in targeted cancer therapies aimed at improving patient outcomes.

Formula: C₂₁H₂₃N₇O₂S

InChI: InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)

InChI key: InChIKey=CUIHSIWYWATEQL-UHFFFAOYSA-N

SMILES: CC1=C2C(C=C(N(C)C3=NC(NC4=CC(S(N)(=O)=O)=C(C)C=C4)=NC=C3)C=C2)=NN1C

Synonyms:

• 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide hydrochloride (1:1)
• 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide
• 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide
• Ae 941
• Benzenesulfonamide, 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-
• Gw 786034
• Votrient
• Pazopanib

Pazopanib

CAS: 444731-52-6

Pazopanib (GW786034) is an inhibitor of protein tyrosine kinases that inhibits VEGFR1/2/3. Pazopanib has antitumor activity. Cost-effective and quality-assured.

Formula: C₂₁H₂₃N₇O₂S

Purity: 98.78% - 99.85%

Color and Shape: White Powder

Molecular weight: 437.52

Ref: TM-T0097L

Pazopanib

CAS: 444731-52-6

Formula: C₂₁H₂₃N₇O₂S

Purity: ≥ 98.0% (dried basis)

Color and Shape: Off-white to light-yellow or beige powder

Molecular weight: 437.52

Ref: 7W-GP3530

Pazopanib

CAS: 444731-52-6

Pazopanib

Purity: 98%

Molecular weight: 437.52g/mol

Ref: 54-OR1029862

Pazopanib

CAS: 444731-52-6

Pazopanib

Purity: ≥98%

Molecular weight: 437.52g/mol

Ref: 54-BUP17708

Pazopanib

CAS: 444731-52-6

Formula: C₂₁H₂₃N₇O₂S

Color and Shape: White To Off-White Solid

Molecular weight: 437.53

Ref: 4Z-P-129001

Pazopanib

CAS: 444731-52-6

Formula: C₂₁H₂₃N₇O₂S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 437.52

Ref: 3B-P2996

Pazopanib

Controlled Product

CAS: 444731-52-6

Applications An oral angiogenesis inhibitor targeting VEGFR and PDGFR.
References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),

Formula: C₂₁H₂₃N₇O₂S

Color and Shape: Neat

Molecular weight: 437.52

Ref: TR-P210925

Pazopanib

CAS: 444731-52-6

Multitargeted tyrosine kinase inhibitor; angiogenesis inhibitor

Formula: C₂₁H₂₃N₇O₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 437.52 g/mol

Ref: 3D-FD26771

Pazopanib - Bio-X ™

CAS: 444731-52-6

Pazopanib is an antineoplastic agent that is used to treat advanced renal cell cancer and advanced soft tissues sarcoma. This drug is a multitargeted tyrosine kinase inhibitor against vascular endothelial growth factor receptor 1, 2, 3 and c-kit. As a result, it increases tumor apoptosis and decreases tumor blood flow.

Formula: C₂₁H₂₃N₇O₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 437.52 g/mol

Ref: 3D-BD164238