CAS 449811-01-2

Pamapimod

Description:

Pamapimod is a small molecule inhibitor primarily known for its role as a selective inhibitor of p38 mitogen-activated protein kinase (MAPK). This compound has garnered attention in the field of pharmacology due to its potential therapeutic applications, particularly in inflammatory diseases and conditions associated with excessive cytokine production. Chemically, pamapimod is characterized by its specific structure that allows it to bind to the ATP-binding site of p38 MAPK, thereby inhibiting its activity. This inhibition can lead to a reduction in the production of pro-inflammatory cytokines, making it a candidate for treating various inflammatory disorders. Pamapimod has been studied in clinical trials for conditions such as rheumatoid arthritis and other autoimmune diseases. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are crucial for determining its efficacy and safety profile in therapeutic applications. Overall, pamapimod represents a significant advancement in targeted therapy for inflammation-related conditions.

Formula: C₁₉H₂₀F₂N₄O₄

InChI: InChI=1S/C19H20F2N4O4/c1-25-17-11(10-22-19(24-17)23-13(4-6-26)5-7-27)8-16(18(25)28)29-15-3-2-12(20)9-14(15)21/h2-3,8-10,13,26-27H,4-7H2,1H3,(H,22,23,24)

InChI key: InChIKey=JYYLVUFNAHSSFE-UHFFFAOYSA-N

SMILES: CN1C=2C(C=C(OC3=C(F)C=C(F)C=C3)C1=O)=CN=C(NC(CCO)CCO)N2

Synonyms:

• 6-(2,4-Difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
• Pamapimod
• R 1503
• Ro 4402257
• Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,4-difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methyl-

Pamapimod

CAS: 449811-01-2

Formula: C₁₉H₂₀F₂N₄O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 406.3833

Ref: IN-DA00DB7C

Pamapimod

CAS: 449811-01-2

Pamapimod

Purity: ≥95%

Molecular weight: 406.38g/mol

Ref: 54-BUP12225

Pamapimod

CAS: 449811-01-2

Pamapimod

Molecular weight: 406.38g/mol

Ref: 54-BISN0219

Pamapimod

CAS: 449811-01-2

Formula: C₁₉H₂₀F₂N₄O₄

Molecular weight: 406.39

Ref: 4Z-P-119001

Pamapimod

CAS: 449811-01-2

Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.

Formula: C₁₉H₂₀F₂N₄O₄

Purity: 99.52% - 99.99%

Color and Shape: Solid

Molecular weight: 406.38

Ref: TM-T6927

Pamapimod

Controlled Product

CAS: 449811-01-2

Applications A selective inhibitor of the α-isoform of p38 MAP kinase. It is used in in treatment of patient with rheumatoid arthritis. Pamapimod was tolerable but not effective as Methotrexate.
References Guan, Z., et al.: J. Biol. Chem., 273, 12901 (1998), Lee, J., et al.: Pharmacol. Ther., 82, 389 (1999), Korb, A., et al.: Arthritis Rheum., 54, 2745 (2006),

Formula: C₁₉H₂₀F₂N₄O₄

Color and Shape: White

Molecular weight: 406.38

Ref: TR-P167500