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CAS 50-18-0

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cyclophosphamide

Description:
Cyclophosphamide is a synthetic alkylating agent primarily used in chemotherapy for various cancers, including lymphomas and leukemias. It belongs to the class of nitrogen mustards and is characterized by its ability to interfere with DNA replication, leading to cell death, particularly in rapidly dividing cells. Cyclophosphamide is a prodrug, meaning it requires metabolic activation in the liver to convert into its active form, which exerts its cytotoxic effects. The compound is typically administered intravenously or orally and is known for its immunosuppressive properties, making it useful in treating autoimmune diseases as well. Its chemical structure includes a phosphoramide group, which contributes to its reactivity. Cyclophosphamide can cause a range of side effects, including nausea, vomiting, and potential long-term risks such as secondary malignancies. Due to its potent effects, careful monitoring and dosage adjustments are essential during treatment. Overall, cyclophosphamide remains a critical agent in oncology and immunology, highlighting its significance in medical therapeutics.
Formula:C7H15Cl2N2O2P
InChI:InChI=1/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
InChI key:InChIKey=CMSMOCZEIVJLDB-UHFFFAOYSA-N
SMILES:N(CCCl)(CCCl)P1(=O)NCCCO1
Synonyms:
  • (RS)-Cyclophosphamide
  • 1-(Bis(2-Chloroethyl)Amino)-1-Oxo-2-Aza-5-Oxaphosphoridine
  • 2-(Bis(2-Chloroethyl)Amino)-1,3,2-Oxazaphosphorinane 2-Oxide
  • 2-(Bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorine 2-oxide
  • 2-(Di(2-Chloroethyl)Amino)-1-Oxa-3-Aza-2-Phosphacyclohexane 2-Oxide
  • 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide
  • 2H-1,3,2-Oxazaphosphorin, 2-amine, N,N-bis((2-chloroethyl)tetrahydro-, 2-oxide
  • 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide
  • Asta B 518
  • B 518
  • See more synonyms
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