CAS 500287-72-9

Rilpivirine

Description:

Rilpivirine is an antiretroviral medication primarily used in the treatment of HIV-1 infection. It belongs to the class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and functions by inhibiting the reverse transcriptase enzyme, which is crucial for viral replication. Rilpivirine is characterized by its relatively long half-life, allowing for once-daily dosing, which enhances patient adherence to treatment regimens. The compound is typically administered in the form of a tablet and is often combined with other antiretroviral agents to improve efficacy and reduce the risk of resistance. Rilpivirine is known for its favorable side effect profile compared to some other antiretrovirals, with a lower incidence of certain adverse effects such as gastrointestinal disturbances and metabolic complications. However, it is contraindicated in patients with a high viral load or those taking certain medications that may interact adversely. Overall, Rilpivirine represents an important option in the management of HIV, contributing to improved outcomes for patients.

Formula: C₂₂H₁₈N₆

InChI: InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+

InChI key: InChIKey=YIBOMRUWOWDFLG-ONEGZZNKSA-N

SMILES: N(C1=C(C)C=C(/C=C/C#N)C=C1C)C2=NC(NC3=CC=C(C#N)C=C3)=NC=C2

Synonyms:

• 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
• 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile
• 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
• Benzonitrile, 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-
• R 278474
• R-278474，Tmc-278
• Rekambys
• Rilpivirine
• Tmc 278

Rilpivirine

CAS: 500287-72-9

Rilpivirine

Purity: 98%

Molecular weight: 366.42g/mol

Ref: 54-OR1026494

Rilpivirine

CAS: 500287-72-9

Rilpivirine

Purity: ≥95%

Molecular weight: 366.42g/mol

Ref: 54-BUP13006

Rilpivirine

CAS: 500287-72-9

Formula: C₂₂H₁₈N₆

Purity: ≥ 98.0%

Color and Shape: White to beige or light yellow powder

Molecular weight: 366.42

Ref: 7W-GP3165

Rilpivirine

CAS: 500287-72-9

Formula: C₂₂H₁₈N₆

Color and Shape: Yellow Solid

Molecular weight: 366.43

Ref: 4Z-R-3410

Rilpivirine

CAS: 500287-72-9

Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment

Formula: C₂₂H₁₈N₆

Purity: 97.22% - 98.83%

Color and Shape: Solid

Molecular weight: 366.42

Ref: TM-T2330

Rilpivirine

Controlled Product

CAS: 500287-72-9

Applications A novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.
References Sun, et al.: J. Med. Chem., 41, 4648 (1998), Kashiwada, et al.: Bioorg. Med. Chem. Lett., 11, 183 (2001),

Formula: C₂₂H₁₈N₆

Color and Shape: Yellow

Molecular weight: 366.42

Ref: TR-R509800

Rilpivirine

CAS: 500287-72-9

Anti-viral; non-nucleoside reverse transcriptase inhibitor

Formula: C₂₂H₁₈N₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 366.42 g/mol

Ref: 3D-FR15845

(2S,3R,4R,5S)-6-((2-((2-((4-Cyanophenyl)amino)pyrimidin-4-yl)amino)-5-((E)-2-cyanovinyl)-3-methylbenzyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid

Controlled Product

CAS: 500287-72-9

Formula: C₂₈H₂₆N₆O₇

Color and Shape: Neat

Molecular weight: 558.542

Ref: TR-C990338

(2S,3R,4R,5S)-6-((2-((2-((4-Cyanophenyl)amino)pyrimidin-4-yl)amino)-5-((E)-2-cyanovinyl)-3-(hydroxymethyl)benzyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid

Controlled Product

CAS: 500287-72-9

Formula: C₂₈H₂₆N₆O₈

Color and Shape: Neat

Molecular weight: 574.541

Ref: TR-C990340