CAS 500287-72-9: Rilpivirine

Description: Rilpivirine is an antiretroviral medication primarily used in the treatment of HIV-1 infection. It belongs to the class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and functions by inhibiting the reverse transcriptase enzyme, which is crucial for viral replication. Rilpivirine is characterized by its relatively long half-life, allowing for once-daily dosing, which enhances patient adherence to treatment regimens. The compound is typically administered in the form of a tablet and is often combined with other antiretroviral agents to improve efficacy and reduce the risk of resistance. Rilpivirine is known for its favorable side effect profile compared to some other antiretrovirals, with a lower incidence of certain adverse effects such as gastrointestinal disturbances and metabolic complications. However, it is contraindicated in patients with a high viral load or those taking certain medications that may interact adversely. Overall, Rilpivirine represents an important option in the management of HIV, contributing to improved outcomes for patients.

Formula: C₂₂H₁₈N₆

InChI: InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+

InChI key: InChIKey=YIBOMRUWOWDFLG-ONEGZZNKSA-N

SMILES: N#CC=CC=1C=C(C(NC2=NC(=NC=C2)NC3=CC=C(C#N)C=C3)=C(C1)C)C

Synonyms:

• 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
• 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile
• 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
• Benzonitrile, 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-
• R 278474
• R-278474，Tmc-278
• Rekambys
• Rilpivirine
• Tmc 278

Rilpivirine

CAS: 500287-72-9

• Purity: 98%
• Molecular weight: 366.42g/mol

Rilpivirine

CAS: 500287-72-9

• Purity: 98.82%
• Molecular weight: 366.42g/mol

Rilpivirine

CAS: 500287-72-9

• Formula: C₂₂H₁₈N₆
• Purity: ≥ 98.0%
• Color and Shape: White to beige or light yellow powder
• Molecular weight: 366.42

Rilpivirine

CAS: 500287-72-9

• Formula: C₂₂H₁₈N₆
• Color and Shape: Yellow Solid
• Molecular weight: 366.43

Rilpivirine

CAS: 500287-72-9

Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 …

• Formula: C₂₂H₁₈N₆
• Purity: 97.22% - 98.83%
• Color and Shape: Solid
• Molecular weight: 366.42

Rilpivirine

CAS: 500287-72-9

Applications A novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less …

• Formula: C₂₂H₁₈N₆
• Color and Shape: Yellow
• Molecular weight: 366.42

Rilpivirine

CAS: 500287-72-9

Anti-viral; non-nucleoside reverse transcriptase inhibitor

• Formula: C₂₂H₁₈N₆
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 366.42 g/mol

(2S,3R,4R,5S)-6-((2-((2-((4-Cyanophenyl)amino)pyrimidin-4-yl)amino)-5-((E)-2-cyanovinyl)-3-methylbenzyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid

CAS: 500287-72-9

• Formula: C₂₈H₂₆N₆O₇
• Color and Shape: Neat
• Molecular weight: 558.542

(2S,3R,4R,5S)-6-((2-((2-((4-Cyanophenyl)amino)pyrimidin-4-yl)amino)-5-((E)-2-cyanovinyl)-3-(hydroxymethyl)benzyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid

CAS: 500287-72-9

• Formula: C₂₈H₂₆N₆O₈
• Color and Shape: Neat
• Molecular weight: 574.541