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CAS 500287-72-9

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Rilpivirine

Description:
Rilpivirine is an antiretroviral medication primarily used in the treatment of HIV-1 infection. It belongs to the class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and functions by inhibiting the reverse transcriptase enzyme, which is crucial for viral replication. Rilpivirine is characterized by its relatively long half-life, allowing for once-daily dosing, which enhances patient adherence to treatment regimens. The compound is typically administered in the form of a tablet and is often combined with other antiretroviral agents to improve efficacy and reduce the risk of resistance. Rilpivirine is known for its favorable side effect profile compared to some other antiretrovirals, with a lower incidence of certain adverse effects such as gastrointestinal disturbances and metabolic complications. However, it is contraindicated in patients with a high viral load or those taking certain medications that may interact adversely. Overall, Rilpivirine represents an important option in the management of HIV, contributing to improved outcomes for patients.
Formula:C22H18N6
InChI:InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+
InChI key:InChIKey=YIBOMRUWOWDFLG-ONEGZZNKSA-N
SMILES:N(C1=C(C)C=C(/C=C/C#N)C=C1C)C2=NC(NC3=CC=C(C#N)C=C3)=NC=C2
Synonyms:
  • 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
  • 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile
  • 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
  • Benzonitrile, 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-
  • R 278474
  • R-278474，Tmc-278
  • Rekambys
  • Rilpivirine
  • Tmc 278
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