CAS 51-21-8

5-Fluorouracil

Description:

5-Fluorouracil (5-FU) is a synthetic pyrimidine analog that serves as an antimetabolite in cancer treatment, primarily targeting rapidly dividing cells. Its chemical formula is C4H3FN2O2, and it is characterized by the presence of a fluorine atom at the 5-position of the uracil ring, which alters its metabolic pathways. 5-FU is typically administered intravenously or topically, depending on the type of cancer being treated, such as colorectal, breast, and skin cancers. The mechanism of action involves the inhibition of thymidylate synthase, leading to a depletion of thymidine triphosphate and ultimately disrupting DNA synthesis and repair. 5-Fluorouracil is known for its side effects, which can include gastrointestinal disturbances, myelosuppression, and mucositis, due to its impact on normal rapidly dividing cells. Its efficacy can be enhanced when used in combination with other chemotherapeutic agents. As a potent chemotherapeutic agent, 5-FU remains a critical component in oncological pharmacotherapy.

Formula: C₄H₃FN₂O₂

InChI: InChI=1/C4H3FN2O2/c5-7-2-1-3(8)6-4(7)9/h1-2H,(H,6,8,9)

InChI key: InChIKey=GHASVSINZRGABV-UHFFFAOYSA-N

SMILES: O=C1C(F)=CNC(=O)N1

Synonyms:

• 1-fluoropyrimidine-2,4(1H,3H)-dione
• 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
• 2,4-Dihydroxy-5-fluoropyrimidine
• 2,4-Dioxo-5-fluoropyrimidine
• 5-Fluoracyl
• 5-Fluoro Uracil
• 5-Fluoro-1H-pyrimidine-2,4-dione
• 5-Fluoro-2,4(1H,3H)-pyrimidinedione
• 5-Fluoro-2,4-(1H,3H)-pyrimidindion
• 5-Fluoro-2,4-Pyrimidinedione
• 5-Fluoro-2,4-dihydroxypyrimidine
• 5-Fluoropyrimidine-2,4-Dione
• 5-Fluoropyrimidine-2,4-diol
• 5-Fluoruracil
• 5-Fu
• 5-Oncouracil
• Adrucil
• Arumel
• Carac
• Carzonal
• Efudex
• Efudix
• Efurix
• FU
• Fluoracil
• Fluoroblastin
• Fluoroplex
• Fluorouracil
• Fluorouracil, 5-
• Fluorouracile
• Fluorouracile Accord
• Fluorouracilo
• Fluorouracilum
• Fluoruracil
• Flurablastin
• Fluracedyl
• Fluracil
• Fluracilum
• Fluri
• Fluril
• Ftoruracil
• Kecimeton
• Nsc 19893
• Phthoruracil
• Phtoruracil
• Queroplex
• Ro 2-9757
• Sigma 03738
• Tegadifure
• Timazin
• U 8953
• Ulup
• Uracil, 5-Fluoro-
• 5-faracil
• 3h)-pyrimidinedione,5-fluoro-4(1h
• 5-FLUOROURACIL
• 5-Fluor-2,4-dihydroxypyrimidin
• 1-FLUORO-1H-PYRIMIDINE-2,4-DIONE
• 5-FLUOROPYRIMIDINE-2,4(1H,3H)-DIONE
• 5-fluor-2,4(1h,3h)-pyrimidindion
• [180]-5-Fluorouracil

5-Fluorouracil

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purity: >99.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 130.08

Ref: 3B-F0151

5-Fluorouracil, 99%

CAS: 51-21-8

5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses

Formula: C₄H₃FN₂O₂

Purity: 99%

Color and Shape: Crystalline powder, White to pale cream

Molecular weight: 130.08

Ref: 02-A13456

Flucytosine EP Impurity A

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Molecular weight: 130.1

Ref: ST-EA-CP-F3001

Fluorouracil

CAS: 51-21-8

Color and Shape: Neat

Ref: 61-FOR0593.00

Fluorouracil

CAS: 51-21-8

Fluorouracil

Color and Shape: White

Ref: 47-995

FLUOROURACIL RS

CAS: 51-21-8

FLUOROURACIL RS

Formula: C₄H₃FN₂O₂

Molecular weight: 130.0772

Ref: 41-ICRS0312

FLUOROURACIL CRS

CAS: 51-21-8

FLUOROURACIL CRS

Color and Shape: Added Modified

Ref: 41-F0250000

Fluorouracil

CAS: 51-21-8

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₄H₃FN₂O₂

Color and Shape: White Off-White Powder

Molecular weight: 130.01786

Ref: 45-1279000

5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 130.0772

Ref: IN-DA003MRU

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis.

Formula: C₄H₃FN₂O₂

Purity: 98% - >99.99%

Color and Shape: White To Practically White Crystalline Powder Neoplastic Drug Chemosterilant For Insects (Epa 1998)

Molecular weight: 130.08

Ref: TM-T0984

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil

Purity: ≥98%

Molecular weight: 130.08g/mol

Ref: 54-BUP17413

5-Fluorouracil

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purity: ≥ 99.0%

Color and Shape: White to almost white crystalline powder

Molecular weight: 130.08

Ref: 7W-GP6168

Fluorouracil-13C-15N2

CAS: 51-21-8

Formula: C₃₁₃CH₃F₁₅N₂O₂

Color and Shape: Pale Yellow Solid

Molecular weight: 133.06

Ref: 4Z-F-532

Fluorouracil

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 130.08

Ref: 4Z-F-536

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil

Formula: C₄H₃FN₂O₂

Purity: 99%

Color and Shape: white solid

Molecular weight: 130.07722g/mol

Ref: 54-PC4380

5-Fluorouracil

Controlled Product

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Color and Shape: Neat

Molecular weight: 130.08

Ref: 04-C13799500

Fluorouracil

CAS: 51-21-8

Color and Shape: Neat

Ref: 86-MM0593.00

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil

Formula: C₄H₃FN₂O₂

Purity: 99%

Color and Shape: white to off-white solid

Molecular weight: 130.07722g/mol

Ref: 54-BIF0123

5-Fluoro Uracil

Controlled Product

CAS: 51-21-8

Impurity Flucytosine EP Impurity A
Applications 5-Fluoro Uracil is is an DNA/RNA synthesis inhibitor. It is used as a potent antitumor agent since it interrupts nucleotide synthetic by inhibiting thymidylate synthase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Longley, D., et al.: Nat. Rev. Cancer, 3, 330 (2003); Bollag, W., et al.: Eur. J. Cancer, 16, 427 (1980); Pinedo, H., et al.: J. Clin. Oncol., 6, 1653 (1988); Ishikawa, T., et al.: Biochem. Pharmacol., 55, 1091 (1998); Schuller, J., et al.: Cancer Chemother. Pharmacol., 45, 291 (2000);

Formula: C₄H₃FN₂O₂

Color and Shape: White

Molecular weight: 130.08

Ref: TR-F596000

5-Fluorouracil - Bio-X ™

CAS: 51-21-8

5-Fluorouracil is a cytotoxic drug that inhibits the synthesis of DNA. It is used in combination therapy to treat cancer and is a pyrimidine analog. This drug inhibits the formation of thymidylate synthase from uracil. As a result, this leads to DNA and RNA synthesis inhibition and cell death.

Formula: C₄H₃FN₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 130.08 g/mol

Ref: 3D-BF166014

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil is a cytotoxic drug used to treat cancer. It is a prodrug that is converted to 5-fluoro-2'-deoxyuridine 5'-triphosphate (5-FUdR) in cells, and inhibits RNA synthesis by interacting with the enzyme thymidylate synthase. This drug has minimal toxicity in humans and has shown promising results against wild-type strains of bacteria. 5-Fluorouracil also has demonstrated synergistic activity when combined with the taxane docetaxel in the treatment of non-small cell lung cancer. 5-Fluorouracil's oral prodrug, fluorouracil, can be administered as an alternative to intravenous administration. The drug is found in many pharmaceutical preparations, including benzalkonium chloride wipes, which are used as topical agents for skin disinfection before surgery or other medical procedures. Blood samples may be drawn from patients who have been

Formula: C₄H₃FN₂O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 130.08 g/mol

Ref: 3D-FF05372

5-Fluorouracil

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 130.078

Ref: 10-F003241

5-Fluorouracil (5-FU) Exiplus, Multi-Compendial, 99%

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purity: min. 99%

Color and Shape: White to off white, Crystalline powder, Clear, Colourless

Molecular weight: 130.08

Ref: SR-59333

5-Fluorouracil (5-FU) extrapure, 99%

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purity: min. 99%

Color and Shape: White to off white, Crystalline powder, Clear, Colourless

Molecular weight: 130.08

Ref: SR-15088