CAS 51-21-8: 5-Fluorouracil

Description: 5-Fluorouracil (5-FU) is a synthetic pyrimidine analog that serves as an antimetabolite in cancer treatment, primarily targeting rapidly dividing cells. Its chemical formula is C4H3FN2O2, and it is characterized by the presence of a fluorine atom at the 5-position of the uracil ring, which alters its metabolic pathways. 5-FU is typically administered intravenously or topically, depending on the type of cancer being treated, such as colorectal, breast, and skin cancers. The mechanism of action involves the inhibition of thymidylate synthase, leading to a depletion of thymidine triphosphate and ultimately disrupting DNA synthesis and repair. 5-Fluorouracil is known for its side effects, which can include gastrointestinal disturbances, myelosuppression, and mucositis, due to its impact on normal rapidly dividing cells. Its efficacy can be enhanced when used in combination with other chemotherapeutic agents. As a potent chemotherapeutic agent, 5-FU remains a critical component in oncological pharmacotherapy.

Formula: C₄H₃FN₂O₂

InChI: InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChI key: InChIKey=GHASVSINZRGABV-UHFFFAOYSA-N

SMILES: O=C1NC=C(F)C(=O)N1

Synonyms:

• 1-fluoropyrimidine-2,4(1H,3H)-dione
• 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
• 2,4-Dihydroxy-5-fluoropyrimidine
• 2,4-Dioxo-5-fluoropyrimidine
• 5-Fluoracyl
• 5-Fluoro Uracil
• 5-Fluoro-1H-pyrimidine-2,4-dione
• 5-Fluoro-2,4(1H,3H)-pyrimidinedione
• 5-Fluoro-2,4-(1H,3H)-pyrimidindion
• 5-Fluoro-2,4-Pyrimidinedione
• 5-Fluoro-2,4-dihydroxypyrimidine
• 5-Fluoropyrimidine-2,4-Dione
• 5-Fluoropyrimidine-2,4-diol
• 5-Fluoruracil
• 5-Fu
• 5-Oncouracil
• Adrucil
• Arumel
• Carac
• Carzonal
• Efudex
• Efudix
• Efurix
• FU
• Fluoracil
• Fluoroblastin
• Fluoroplex
• Fluorouracil
• Fluorouracil, 5-
• Fluorouracile
• Fluorouracile Accord
• Fluorouracilo
• Fluorouracilum
• Fluoruracil
• Flurablastin
• Fluracedyl
• Fluracil
• Fluracilum
• Fluri
• Fluril
• Ftoruracil
• Kecimeton
• Nsc 19893
• Phthoruracil
• Phtoruracil
• Queroplex
• Ro 2-9757
• Sigma 03738
• Tegadifure
• Timazin
• U 8953
• Ulup
• Uracil, 5-Fluoro-

5-Fluorouracil

CAS: 51-21-8

Thymidylate synthase inhibitor; anti-cancer drug

• Formula: C₄H₃FN₂O₂
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 130.08 g/mol

5-Fluorouracil (5-FU) Exiplus, Multi-Compendial, 99%

CAS: 51-21-8

• Formula: C₄H₃FN₂O₂
• Purity: min. 99%
• Color and Shape: White to off white, Crystalline powder, Clear, Colourless
• Molecular weight: 130.08

5-Fluorouracil (5-FU) extrapure, 99%

CAS: 51-21-8

• Formula: C₄H₃FN₂O₂
• Purity: min. 99%
• Color and Shape: White to off white, Crystalline powder, Clear, Colourless
• Molecular weight: 130.08