CAS 51-21-8

5-Fluorouracil

Description:

5-Fluorouracil (5-FU) is a synthetic pyrimidine analog that serves as an antimetabolite in cancer treatment, primarily targeting rapidly dividing cells. Its chemical formula is C4H3FN2O2, and it is characterized by the presence of a fluorine atom at the 5-position of the uracil ring, which alters its metabolic pathways. 5-FU is typically administered intravenously or topically, depending on the type of cancer being treated, such as colorectal, breast, and skin cancers. The mechanism of action involves the inhibition of thymidylate synthase, leading to a depletion of thymidine triphosphate and ultimately disrupting DNA synthesis and repair. 5-Fluorouracil is known for its side effects, which can include gastrointestinal disturbances, myelosuppression, and mucositis, due to its impact on normal rapidly dividing cells. Its efficacy can be enhanced when used in combination with other chemotherapeutic agents. As a potent chemotherapeutic agent, 5-FU remains a critical component in oncological pharmacotherapy.

Formula: C₄H₃FN₂O₂

InChI: InChI=1/C4H3FN2O2/c5-7-2-1-3(8)6-4(7)9/h1-2H,(H,6,8,9)

InChI key: InChIKey=GHASVSINZRGABV-UHFFFAOYSA-N

SMILES: O=C1C(F)=CNC(=O)N1

Synonyms:

• 1-fluoropyrimidine-2,4(1H,3H)-dione
• 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
• 2,4-Dihydroxy-5-fluoropyrimidine
• 2,4-Dioxo-5-fluoropyrimidine
• 5-Fluoracyl
• 5-Fluoro Uracil
• 5-Fluoro-1H-pyrimidine-2,4-dione
• 5-Fluoro-2,4(1H,3H)-pyrimidinedione
• 5-Fluoro-2,4-(1H,3H)-pyrimidindion
• 5-Fluoro-2,4-Pyrimidinedione
• 5-Fluoro-2,4-dihydroxypyrimidine
• 5-Fluoropyrimidine-2,4-Dione
• 5-Fluoropyrimidine-2,4-diol
• 5-Fluoruracil
• 5-Fu
• 5-Oncouracil
• Adrucil
• Arumel
• Carac
• Carzonal
• Efudex
• Efudix
• Efurix
• FU
• Fluoracil
• Fluoroblastin
• Fluoroplex
• Fluorouracil
• Fluorouracil, 5-
• Fluorouracile
• Fluorouracile Accord
• Fluorouracilo
• Fluorouracilum
• Fluoruracil
• Flurablastin
• Fluracedyl
• Fluracil
• Fluracilum
• Fluri
• Fluril
• Ftoruracil
• Kecimeton
• Nsc 19893
• Phthoruracil
• Phtoruracil
• Queroplex
• Ro 2-9757
• Sigma 03738
• Tegadifure
• Timazin
• U 8953
• Ulup
• Uracil, 5-Fluoro-
• 5-faracil
• 3h)-pyrimidinedione,5-fluoro-4(1h
• 5-FLUOROURACIL
• 5-Fluor-2,4-dihydroxypyrimidin
• 1-FLUORO-1H-PYRIMIDINE-2,4-DIONE
• 5-FLUOROPYRIMIDINE-2,4(1H,3H)-DIONE
• 5-fluor-2,4(1h,3h)-pyrimidindion
• [180]-5-Fluorouracil

5-Fluorouracil

CAS: 51-21-8

5-Fluorouracil is a cytotoxic drug used to treat cancer. It is a prodrug that is converted to 5-fluoro-2'-deoxyuridine 5'-triphosphate (5-FUdR) in cells, and inhibits RNA synthesis by interacting with the enzyme thymidylate synthase. This drug has minimal toxicity in humans and has shown promising results against wild-type strains of bacteria. 5-Fluorouracil also has demonstrated synergistic activity when combined with the taxane docetaxel in the treatment of non-small cell lung cancer. 5-Fluorouracil's oral prodrug, fluorouracil, can be administered as an alternative to intravenous administration. The drug is found in many pharmaceutical preparations, including benzalkonium chloride wipes, which are used as topical agents for skin disinfection before surgery or other medical procedures. Blood samples may be drawn from patients who have been

Formula: C₄H₃FN₂O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 130.08 g/mol

Ref: 3D-FF05372

5-Fluorouracil

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 130.078

Ref: 10-F003241

5-Fluorouracil (5-FU) Exiplus, Multi-Compendial, 99%

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purity: min. 99%

Color and Shape: White to off white, Crystalline powder, Clear, Colourless

Molecular weight: 130.08

Ref: SR-59333

5-Fluorouracil (5-FU) extrapure, 99%

CAS: 51-21-8

Formula: C₄H₃FN₂O₂

Purity: min. 99%

Color and Shape: White to off white, Crystalline powder, Clear, Colourless

Molecular weight: 130.08

Ref: SR-15088