CAS 51-21-8
:5-Fluorouracil
Description:
5-Fluorouracil (5-FU) is a synthetic pyrimidine analog that serves as an antimetabolite in cancer treatment, primarily targeting rapidly dividing cells. Its chemical formula is C4H3FN2O2, and it is characterized by the presence of a fluorine atom at the 5-position of the uracil ring, which alters its metabolic pathways. 5-FU is typically administered intravenously or topically, depending on the type of cancer being treated, such as colorectal, breast, and skin cancers. The mechanism of action involves the inhibition of thymidylate synthase, leading to a depletion of thymidine triphosphate and ultimately disrupting DNA synthesis and repair. 5-Fluorouracil is known for its side effects, which can include gastrointestinal disturbances, myelosuppression, and mucositis, due to its impact on normal rapidly dividing cells. Its efficacy can be enhanced when used in combination with other chemotherapeutic agents. As a potent chemotherapeutic agent, 5-FU remains a critical component in oncological pharmacotherapy.
Formula:C4H3FN2O2
InChI:InChI=1/C4H3FN2O2/c5-7-2-1-3(8)6-4(7)9/h1-2H,(H,6,8,9)
InChI key:InChIKey=GHASVSINZRGABV-UHFFFAOYSA-N
SMILES:O=C1C(F)=CNC(=O)N1
Synonyms:- 1-fluoropyrimidine-2,4(1H,3H)-dione
- 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
- 2,4-Dihydroxy-5-fluoropyrimidine
- 2,4-Dioxo-5-fluoropyrimidine
- 5-Fluoracyl
- 5-Fluoro Uracil
- 5-Fluoro-1H-pyrimidine-2,4-dione
- 5-Fluoro-2,4(1H,3H)-pyrimidinedione
- 5-Fluoro-2,4-(1H,3H)-pyrimidindion
- 5-Fluoro-2,4-Pyrimidinedione
- 5-Fluoro-2,4-dihydroxypyrimidine
- 5-Fluoropyrimidine-2,4-Dione
- 5-Fluoropyrimidine-2,4-diol
- 5-Fluoruracil
- 5-Fu
- 5-Oncouracil
- Adrucil
- Arumel
- Carac
- Carzonal
- Efudex
- Efudix
- Efurix
- FU
- Fluoracil
- Fluoroblastin
- Fluoroplex
- Fluorouracil
- Fluorouracil, 5-
- Fluorouracile
- Fluorouracile Accord
- Fluorouracilo
- Fluorouracilum
- Fluoruracil
- Flurablastin
- Fluracedyl
- Fluracil
- Fluracilum
- Fluri
- Fluril
- Ftoruracil
- Kecimeton
- Nsc 19893
- Phthoruracil
- Phtoruracil
- Queroplex
- Ro 2-9757
- Sigma 03738
- Tegadifure
- Timazin
- U 8953
- Ulup
- Uracil, 5-Fluoro-
- 5-faracil
- 3h)-pyrimidinedione,5-fluoro-4(1h
- 5-FLUOROURACIL
- 5-Fluor-2,4-dihydroxypyrimidin
- 1-FLUORO-1H-PYRIMIDINE-2,4-DIONE
- 5-FLUOROPYRIMIDINE-2,4(1H,3H)-DIONE
- 5-fluor-2,4(1h,3h)-pyrimidindion
- [180]-5-Fluorouracil
- See more synonyms
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5-Fluorouracil
CAS:Formula:C4H3FN2O2Purity:>99.0%(HPLC)(T)Color and Shape:White to Almost white powder to crystalMolecular weight:130.085-Fluorouracil, 99%
CAS:5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratosesFormula:C4H3FN2O2Purity:99%Color and Shape:Crystalline powder, White to pale creamMolecular weight:130.08Fluorouracil
CAS:Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureFormula:C4H3FN2O2Color and Shape:White Off-White PowderMolecular weight:130.017865-Fluorouracil
CAS:5-FluorouracilFormula:C4H3FN2O2Purity:99%Color and Shape:White Solid-PowderMolecular weight:130.077225-Fluorouracil
CAS:5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis.Formula:C4H3FN2O2Purity:98% - >99.99%Color and Shape:White SolidMolecular weight:130.07725-Fluorouracil
CAS:Formula:C4H3FN2O2Purity:≥ 99.0%Color and Shape:White to almost white crystalline powderMolecular weight:130.08Fluorouracil-13C-15N2
CAS:Formula:C313CH3F15N2O2Color and Shape:Pale Yellow SolidMolecular weight:133.065-Fluorouracil (Standard)
CAS:5-Fluorouracil (Standard) is a reference standard for research and analysis in studies involving 5-Fluorouracil. 5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis. 5-Fluorouracil has antitumor activity and affects pyrimidine synthesis through inhibition of thymidylate synthase. 5-Fluorouracil causes apoptosis and autophagy.Formula:C4H3FN2O2Color and Shape:SolidMolecular weight:130.07725-Fluoro Uracil
CAS:Controlled ProductImpurity Flucytosine EP Impurity A
Applications 5-Fluoro Uracil is is an DNA/RNA synthesis inhibitor. It is used as a potent antitumor agent since it interrupts nucleotide synthetic by inhibiting thymidylate synthase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Longley, D., et al.: Nat. Rev. Cancer, 3, 330 (2003); Bollag, W., et al.: Eur. J. Cancer, 16, 427 (1980); Pinedo, H., et al.: J. Clin. Oncol., 6, 1653 (1988); Ishikawa, T., et al.: Biochem. Pharmacol., 55, 1091 (1998); Schuller, J., et al.: Cancer Chemother. Pharmacol., 45, 291 (2000);Formula:C4H3FN2O2Color and Shape:NeatMolecular weight:130.085-Fluorouracil
CAS:5-Fluoropyrimidine-2,4(1H,3H)-dioneFormula:C4H3FN2O2Purity:98%Molecular weight:130.08
