CAS 51-52-5

Propylthiouracil

Description:

Propylthiouracil (PTU) is an antithyroid medication primarily used to manage hyperthyroidism, particularly in conditions like Graves' disease. It functions by inhibiting the enzyme thyroid peroxidase, which is crucial for the synthesis of thyroid hormones, thereby reducing their production. PTU is a white to off-white crystalline powder that is slightly soluble in water and more soluble in organic solvents. Its molecular formula is C7H10N2OS, and it has a molecular weight of approximately 170.24 g/mol. The compound is known for its ability to cross the placenta and is sometimes used in pregnant women to treat hyperthyroidism, although caution is advised due to potential side effects. Common side effects include rash, liver toxicity, and agranulocytosis, necessitating regular monitoring of blood counts during treatment. Propylthiouracil is typically administered orally and is available in tablet form. Its pharmacokinetics involve rapid absorption and a relatively short half-life, requiring multiple daily doses for effective management of thyroid hormone levels.

Formula: C₇H₁₀N₂OS

InChI: InChI=1/C7H10N2OS/c1-2-4-9-5-3-6(10)8-7(9)11/h3,5H,2,4H2,1H3,(H,8,10,11)

InChI key: InChIKey=KNAHARQHSZJURB-UHFFFAOYSA-N

SMILES: C(CC)C1=CC(=O)NC(=S)N1

Synonyms:

• 1-propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
• 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone
• 2-Mercapto-4-hydroxy-6-n-propylpyrimidine
• 2-Mercapto-4-hydroxy-6-propylpyrimidine
• 2-Mercapto-6-propylpyrimidin-4-ol
• 2-Thio-4-oxo-6-propyl-1,3-pyrimidine
• 2-Thio-6-propyl-1,3-pyrimidin-4-one
• 4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo-
• 6-Propyl-2-Thiouracyle
• 6-Propyl-2-thio-2,4(1H,3H)pyrimidinedione
• 6-Propyl-2-thiouracil
• 6-Propyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
• 6-Propylthiouracil
• 6-n-Propyl-2-thiouracil
• 6-n-Propylthiouracil
• Nsc 6498
• Nsc 70461
• PTU
• PTU (thyreostatic)
• Procasil
• Propacil
• Propiltiouracilo
• Propycil
• Propyl-Thiorist
• Propyl-Thyracil
• Propylthiorit
• Propylthiouracil
• Propylthiouracile
• Prothiucil
• Prothiurone
• Prothycil
• Prothyran
• Protiural
• Thiuragyl
• Thyreostat II
• Uracil, 4-Propyl-2-Thio-
• Uracil, 6-propyl-2-thio-
• 2,3-dihydro-6-propyl-2-thioxo-4(1h)-pyrimidinon
• 2-Mercapto-6-propyl-4-pyrimidone
• 2-THIO-4-HYDROXY-6-N-PROPYL-PYRIMIDINE
• 4-PROPYL-2-THIOURACIL
• 4-HYDROXY-2-MERCAPTO-6-PROPYLPYRIMIDINE
• 6-N-PROPYL-2-MERCAPTO-4-HYDROXYPYRIMIDINE
• OTAVA-BB BB7012240174

6-Propyl-2-thiouracil

CAS: 51-52-5

Formula: C₇H₁₀N₂OS

Purity: >99.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 170.23

Ref: 3B-P0533

PROPYLTHIOURACIL RS

CAS: 51-52-5

PROPYLTHIOURACIL RS

Formula: C₇H₁₀N₂OS

Molecular weight: 170.2321

Ref: 41-ICRS0403

PROPYLTHIOURACIL CRS

CAS: 51-52-5

PROPYLTHIOURACIL CRS

Formula: C₇H₁₀N₂OS

Color and Shape: Crystalline Powder. White. Crystals. Powder.

Molecular weight: 170.2321

Ref: 41-P3700000

Propylthiouracil

CAS: 51-52-5

Drugs containing a pyrimidine ring (whether or not hydr

Formula: C₇H₁₀N₂OS

Color and Shape: White Crystalline Powder

Molecular weight: 170.23 g/mol

Ref: 45-1578000

Propylthiouracil

CAS: 51-52-5

Formula: C₇H₁₀N₂OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 170.2321

Ref: IN-DA003HIA

Propylthiouracil

CAS: 51-52-5

Propylthiouracil (6-n-Propylthiouracil) is a thyroid peroxidase inhibitor and also a 5' -deiodinase inhibitor.

Formula: C₇H₁₀N₂OS

Purity: 99.24%

Color and Shape: White Crystalline Powder Of Starch-Like Appearance To Eye And To Touch Saturated Solution Is Neutral Or Slightly Acid To Litmus (Ntp 1992)

Molecular weight: 170.23

Ref: TM-T1309

Propylthiouracil

CAS: 51-52-5

Propylthiouracil

Purity: ≥98%

Molecular weight: 170.23g/mol

Ref: 54-BUP14156

6-Propyl-2-thiouracil

CAS: 51-52-5

Formula: C₇H₁₀N₂OS

Color and Shape: Neat

Molecular weight: 170.23

Ref: 04-C16530500

Propylthiouracil

CAS: 51-52-5

Formula: C₇H₁₀N₂OS

Color and Shape: Neat

Molecular weight: 170.23

Ref: 86-MM3284.00

6-Propyl-2-thiouracil

CAS: 51-52-5

6-Propyl-2-thiouracil

Formula: C₇H₁₀N₂OS

Purity: 97%

Color and Shape: white powder

Molecular weight: 170.2321g/mol

Ref: 54-OR11311

6-Propyl-2-thiouracil

CAS: 51-52-5

Formula: C₇H₁₀N₂OS

Purity: ≥ 97.5%

Color and Shape: White to pale yellow crystalline powder

Molecular weight: 170.23

Ref: 7W-GK3084

Propylthiouracil

Controlled Product

CAS: 51-52-5

Applications Antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen.
References Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 6, 457 (1977), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984),

Formula: C₇H₁₀N₂OS

Color and Shape: White To Off-White

Molecular weight: 170.23

Ref: TR-P838310

6-Propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

CAS: 51-52-5

Formula: C₇H₁₀N₂OS

Purity: 95%

Color and Shape: Crystalline,Powder

Molecular weight: 170.23

Ref: 10-F463632

Propylthiouracil

CAS: 51-52-5

Color and Shape: Neat

Ref: 61-FOR3284.00