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CAS 530-43-8

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Chloramphenicol palmitate

Description:
Chloramphenicol palmitate is an ester derivative of chloramphenicol, a broad-spectrum antibiotic. It is primarily used in the treatment of bacterial infections, particularly in pediatric medicine due to its palmitate form, which enhances its solubility and absorption in the gastrointestinal tract. The substance appears as a white to off-white crystalline powder and is typically administered in oral formulations. Chloramphenicol palmitate is characterized by its ability to inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit, making it effective against a variety of gram-positive and gram-negative bacteria. However, its use is limited due to potential side effects, including the risk of aplastic anemia and gray baby syndrome in neonates. The compound is also subject to strict regulatory controls in many countries due to these safety concerns. Proper storage conditions are essential to maintain its stability, and it should be kept in a cool, dry place, away from light.
Formula:C27H42Cl2N2O6
InChI:InChI=1S/C27H42Cl2N2O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-24(32)37-20-23(30-27(34)26(28)29)25(33)21-16-18-22(19-17-21)31(35)36/h16-19,23,25-26,33H,2-15,20H2,1H3,(H,30,34)/t23-,25-/m1/s1
InChI key:InChIKey=PXKHGMGELZGJQE-ILBGXUMGSA-N
SMILES:[C@@H]([C@@H](COC(CCCCCCCCCCCCCCC)=O)NC(C(Cl)Cl)=O)(O)C1=CC=C(N(=O)=O)C=C1
Synonyms:
  • (2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl hexadecanoate
  • 2-[(Dichloroacetyl)Amino]-3-Hydroxy-3-(4-Nitrophenyl)Propyl Hexadecanoate
  • <span class="text-smallcaps">D</span>-(-)-Chloramphenicol palmitate
  • Acetamide, 2,2-dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl]-, α-palmitate, <span class="text-smallcaps">D</span>-threo-
  • Ai3-51715
  • Brn 2826438
  • CAP-palmitate
  • Cap-P
  • Chlorambon
  • Chloramphenicol monopalmitate
  • See more synonyms
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Found 17 products.