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CAS 54029-12-8

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(±)-Albendazole sulfoxide

Description:
(±)-Albendazole sulfoxide is a chemical compound that serves as a metabolite of the anthelmintic drug albendazole, which is widely used to treat parasitic infections. It is characterized by its sulfoxide functional group, which contributes to its biological activity. The compound is typically a white to off-white solid, exhibiting low solubility in water but higher solubility in organic solvents. Its molecular structure includes a benzimidazole ring, which is crucial for its pharmacological properties. (±)-Albendazole sulfoxide is known for its ability to inhibit the polymerization of tubulin, thereby disrupting microtubule formation in parasites. This mechanism of action makes it effective against a variety of helminths and some protozoa. The compound is also notable for its relatively low toxicity in humans, which enhances its therapeutic profile. In terms of stability, it is generally stable under normal conditions but may degrade under extreme pH or temperature. Overall, (±)-Albendazole sulfoxide plays a significant role in the treatment of parasitic diseases, contributing to the efficacy of albendazole-based therapies.
Formula:C12H15N3O3S
InChI:InChI=1/C7H9NO3S/c1-12(10,11)8-6-2-4-7(9)5-3-6/h2-5,8-9H,1H3
InChI key:InChIKey=VXTGHWHFYNYFFV-UHFFFAOYSA-N
SMILES:S(CCC)(=O)C=1C=C2C(N=C(NC(OC)=O)N2)=CC1
Synonyms:
  • Albendazole S-oxide
  • Albendazole Sulfoxide
  • Carbamic acid, N-[6-(propylsulfinyl)-1H-benzimidazol-2-yl]-, methyl ester
  • Carbamic acid, [5-(propylsulfinyl)-1H-benzimidazol-2-yl]-, methyl ester
  • Methyl [5-(propylsulfinyl)-1H-benzimidazol-2-yl]carbamate
  • N-(4-hydroxyphenyl)methanesulfonamide
  • Ricobendazole
  • Rs 8852
  • Rycobendazole
  • methyl (5-propylsulfinyl-3H-benzoimidazol-2-yl)aminoformate
  • See more synonyms
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