CAS 54301-15-4

Amsacrine hydrochloride

Description:

Amsacrine hydrochloride is a synthetic compound primarily used as an antineoplastic agent in cancer treatment, particularly for certain types of leukemia and lymphomas. It belongs to the class of acridine derivatives and functions as a topoisomerase II inhibitor, disrupting DNA replication and transcription, which ultimately leads to cell death in rapidly dividing cancer cells. The compound is typically administered intravenously and is known for its ability to penetrate cellular membranes effectively. Amsacrine hydrochloride is characterized by its solubility in water and its stability under acidic conditions, which is important for its formulation and storage. Its chemical structure includes a tricyclic acridine core, contributing to its biological activity. While it has shown efficacy in clinical settings, it is also associated with potential side effects, including myelosuppression and cardiotoxicity, necessitating careful monitoring during treatment. As with many chemotherapeutic agents, its use is often balanced against the potential for adverse effects, making patient management crucial in therapeutic applications.

Formula: C₂₁H₂₀ClN₃O₃S

InChI: InChI=1/C21H19N3O3S.ClH/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21;/h3-13,24H,1-2H3,(H,22,23);1H

InChI key: InChIKey=WDISRLXRMMTXEV-UHFFFAOYSA-N

SMILES: N(C=1C2=C(N=C3C1C=CC=C3)C=CC=C2)C4=C(OC)C=C(NS(C)(=O)=O)C=C4.Cl

Synonyms:

• 4′-(Acridin-9-ylamino)-3′-methoxymethanesulfonanilide hydrochloride
• AMSA hydrochloride
• Methanesulfonamide, N-[4- (9-acridinylamino)-3-methoxyphenyl]-, monohydrochloride
• N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide hydrochloride
• N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide hydrochloride (1:1)
• N-[4-(Acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide hydrochloride (1:1)
• NSC 141549
• m-AMSA hydrochloride
• methanesulfonamide, N-[4-(9-acridinylamino)-3-methoxyphenyl]-, hydrochloride (1:1)
• 4’-((9-acridinyl)amino)-methanesulfon-m-anisidinhydrochloride
• m-AMSA, 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride
• 4’-(9-acridinylamino)-methanesulfon-m-anisididmonohydrochloride
• Amsacrine hydrochloride, ≥98% (HPLC)
• M-Amsacrine
• AMSACRINE HYDROCHLORIDE
• N-(4-(acridin-9-ylaMino)-3-Methoxyphenyl)MethanesulfonaMide hydrochloride
• Methanesulfone-m-anisidine-4'-[(9-acridinyl)amino] hydrochloride
• 4’-(9-acridinylamino)methanesulfon-m-anisidemonohydrochloride
• Methansulfon-m-aniside, 4'-(9-acridinylamino)-, monohydrochloride
• nsc141549
• META-AMSACRINE
• n-(4-(9-acridinylamino)-3-methoxyphenyl)-methanesulfonamidmonohydrochlor
• Methanesulfon-m-anisidide 4'-(9-acridinylamino)-
• M-AMSA, HCL
• acridinyl anisidide hydrochloride
• AMine hydrochloride benzene acridine
• 4’-(9-acridinylamino)-methanesulfonyl-m-anisidinmonohydrochloride
• 4-[9-ACRIDINYLAMINO]-N-[METHANE-SULFONYL]-M-ANISIDINE HYDROCHLORIDE
• Amsacrine Hydrochloride, 4-(9-Acridinylamino)-N-(Methanesulfonyl)-M-Anisidine Hydrochloride

Amsacrine hydrochloride

CAS: 54301-15-4

Formula: C₂₁H₂₀ClN₃O₃S

Purity: %

Color and Shape: Solid

Molecular weight: 429.9198

Ref: IN-DA00ILP1

N-(4-(Acridin-9-Ylamino)-3-Methoxyphenyl)Methanesulfonamide Hydrochloride

CAS: 54301-15-4

N-(4-(Acridin-9-Ylamino)-3-Methoxyphenyl)Methanesulfonamide Hydrochloride

Purity: 98+%

Molecular weight: 429.92g/mol

Ref: 54-OR1027547

Amsacrine hydrochloride

CAS: 54301-15-4

Amsacrine hydrochloride

Purity: ≥98%

Molecular weight: 429.92g/mol

Ref: 54-BUP15742

Amsacrine hydrochloride

CAS: 54301-15-4

Formula: C₂₁H₁₉N₃O₃S·HCl

Purity: ≥ 98.0% (dried basis)

Color and Shape: Red to brown powder

Molecular weight: 429.92

Ref: 7W-GL7076

Amsacrine hydrochloride

CAS: 54301-15-4

Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.

Formula: C₂₁H₂₀ClN₃O₃S

Purity: 99.05% - 99.92%

Color and Shape: Solid

Molecular weight: 429.92

Ref: TM-T5820

Amsacrine Hydrochloride

CAS: 54301-15-4

Formula: C₂₁H₁₉N₃O₃S·HCl

Color and Shape: Neat

Molecular weight: 429.9

Ref: TR-A898600

Amsacrine hydrochloride

CAS: 54301-15-4

Purity: 98%

Molecular weight: 429.920013427734

Ref: 10-F864006

Amsacrine Hydrochloride

CAS: 51264-14-3, 54301-15-4

Formula: C₂₁H₁₉N₃O₃S·HCl

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: Light yellow to Amber to Dark green powder to crystal

Molecular weight: 429.92

Ref: 3B-A2777