CAS 56-49-5

3-Methylcholanthrene

Description:

3-Methylcholanthrene is a polycyclic aromatic hydrocarbon (PAH) characterized by its complex structure, which includes multiple fused aromatic rings. It is a derivative of cholanthrene, with a methyl group attached at the third position. This compound is known for its significant role in cancer research, particularly in studies related to carcinogenesis, as it is a potent mutagen and has been shown to induce tumors in laboratory animals. 3-Methylcholanthrene is typically a solid at room temperature and is insoluble in water but soluble in organic solvents such as benzene and chloroform. Its chemical formula is C18H14, and it exhibits a characteristic fluorescence under ultraviolet light. The compound is also known for its stability and persistence in the environment, raising concerns regarding its potential health effects and ecological impact. Due to its carcinogenic properties, handling 3-Methylcholanthrene requires strict safety precautions in laboratory settings.

Formula: C₂₁H₁₆

InChI: InChI=1/C21H16/c1-13-11-15-6-4-7-16-12-19-17-8-3-2-5-14(17)9-10-18(19)20(13)21(15)16/h2-10,12-13H,11H2,1H3

InChI key: InChIKey=PPQNQXQZIWHJRB-UHFFFAOYSA-N

SMILES: CC1=C2C3=C(C=4C(C=C3C=C1)=C5C(=CC4)C=CC=C5)CC2

Synonyms:

• 1,2-Dihydro-3-methylbenz(j)aceanthrylene
• 1-Methyl-1,2-Dihydrocyclopenta[Ij]Tetraphene
• 20-Mc
• 20-Methylcholanthrene
• 3-Mc
• 3-Mch
• 3-MeCA
• 3-Methoxycholanthrene
• 3-Methyl-1,2-Dihydrocyclopenta[Ij]Tetraphene
• 3-Methyl-1,2-dihydrobenzo[j]aceanthrylene
• 3-Methyl-I,J-cyclopentabenz(a)anthracene
• 3-Methylbenz(j)aceanthrene
• 3-Methylchloanthrene
• 3-Methylcholanthren
• 3-Methylcholanthren [German]
• 3-Methylcyclopentabenzophenanthrene
• 3-Metilcolantreno
• Ai3-50462
• Benz(j)aceanthrylene, 1,2-dihydro-3-methyl-
• Brn 1913890
• Ccris 386
• Cholanthrene, 3-methyl-
• Hsdb 2942
• MCA
• Methylcholanthrene
• Nsc 21970
• RCRA waste no. U157
• RCRA waste number U157
• 4-05-00-02648 (Beilstein Handbook Reference)
• 1,2-dihydro-3-methyl-benz(j)aceanthrylen
• 20-methylchlolanthrene
• 3-METHYLCHOLANTHRENE
• 3-methyl-cholanthren
• 3-Methylcholanthrene-(20)
• 3-MCA

3-Methylcholanthrene

CAS: 56-49-5

Formula: C₂₁H₁₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 268.3517

Ref: IN-DA00DEP5

3-Methyl-1,2-dihydrocyclopenta[ij]tetraphene

CAS: 56-49-5

3-Methyl-1,2-dihydrocyclopenta[ij]tetraphene

Purity: 98%

Molecular weight: 268.36g/mol

Ref: 54-OR1067137

EPA Method 610 Additions PAH Mixture 446 1000 µg/mL in Dichloromethane

Controlled Product

CAS: 189-55-9, 189-64-0, 192-65-4, 194-59-2, 205-82-3, 224-42-0, 226-36-8, 56-49-5

Color and Shape: Mixture

Ref: 04-A50000446DI

EPA Method 8270 Appendix IX Mixture 2 1000 µg/mL in Dichloromethane

Controlled Product

CAS: 100-52-7, 101-84-8, 105-60-2, 120-58-1, 123-91-1, 130-15-4, 140-57-8, 143-50-0, 1888-71-7, 224-42-0, 2303-16-4, 23950-58-5, 465-73-6, 510-15-6, 56-49-5, 56-57-5, 57-97-6, 608-93-5, 62-44-2, 62-50-0, 66-27-3, 76-01-7, 82-68-8, 87-65-0, 90-13-1, 92-52-4, 94-59-7, 95-94-3, 97-63-2, 98-86-2, 99-35-4

Formula: C₆H₂Cl₄

Color and Shape: Mixture

Molecular weight: 215.89

Ref: 04-GA09000445DI

EPA Method 610 Additions PAH Mixture 445 5-100 µg/mL in Acetonitrile

CAS: 120-12-7, 129-00-0, 189-55-9, 189-64-0, 191-24-2, 192-65-4, 193-39-5, 194-59-2, 205-82-3, 205-99-2, 206-44-0, 207-08-9, 208-96-8, 218-01-9, 224-42-0, 226-36-8, 50-32-8, 53-70-3, 56-49-5, 56-55-3, 83-32-9, 85-01-8, 86-73-7, 91-20-3

Color and Shape: Mixture

Ref: 04-A50000445AL

EPA Method 8270 App. IX Calibration Mixture 602 1000 µg/mL in Dichloromethane

Controlled Product

CAS: 100-51-6, 100-75-4, 10595-95-6, 108-39-4, 109-06-8, 110-86-1, 120-58-1, 122-39-4, 134-32-7, 1888-71-7, 53-96-3, 55-18-5, 56-49-5, 56-57-5, 57-97-6, 58-90-2, 59-89-2, 60-11-7, 608-93-5, 62-44-2, 62-53-3, 76-01-7, 82-68-8, 87-65-0, 88-85-7, 91-59-8, 92-67-1, 924-16-3, 930-55-2, 94-59-7, 95-53-4, 95-94-3, 98-86-2, 99-35-4, 99-55-8, 99-65-0

Color and Shape: Mixture

Ref: 04-A50000602DI

3-Methylcholanthrene

Controlled Product

CAS: 56-49-5

Formula: C₂₁H₁₆

Color and Shape: Neat

Molecular weight: 268.35

Ref: 04-C20850000

EPA Method 8270 Calibration by Class Mixture 2000 µg/mL in Dichloromethane

Controlled Product

CAS: 120-12-7, 129-00-0, 191-24-2, 193-39-5, 205-99-2, 206-44-0, 207-08-9, 208-96-8, 218-01-9, 50-32-8, 53-70-3, 56-49-5, 56-55-3, 83-32-9, 85-01-8, 86-73-7, 90-12-0, 91-20-3, 91-57-6

Formula: C₁₁H₁₀

Color and Shape: Mixture

Molecular weight: 142.20

Ref: 04-GA09000441DI

3-Methylcholanthrene

Controlled Product

CAS: 56-49-5

Applications A carcinogen.

Formula: C₂₁H₁₆

Color and Shape: Yellow To Dark Yellow

Molecular weight: 268.35

Ref: TR-M294460

3-Methylcholanthrene

Controlled Product

CAS: 56-49-5

3-Methylcholanthrene (3MC) is a mutagen that has been shown to be carcinogenic in animals. It binds to the DNA, which causes breaks in the DNA strands and leads to mutations. 3MC is also an inducer of tumor formation and is active against murine sarcoma virus. 3MC has been shown to induce enzyme activities in vitro and can be used to study the effects of enzyme inhibitors on enzymatic activity. 3MC has been shown to have potent inducers of tumor formation, especially when administered at high doses. The potent tumor-promoting effect may be due to its ability to bind with DNA and inhibit the synthesis of RNA, leading to increased proliferation of hepatocyte-like cells.

Formula: C₂₁H₁₆

Purity: Min. 95%

Color and Shape: Yellow Clear Liquid

Molecular weight: 268.35 g/mol

Ref: 3D-FM25802