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CAS 58-33-3

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Promethazine hydrochloride

Description:
Promethazine hydrochloride is an antihistamine medication primarily used to treat allergies, motion sickness, and nausea, as well as to induce sedation. It belongs to the phenothiazine class of compounds and functions by blocking histamine H1 receptors, thereby alleviating allergic symptoms. This substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for various formulations, including tablets, syrups, and injectable forms. Promethazine hydrochloride has a relatively low molecular weight and exhibits a melting point that allows for easy handling and formulation. Its pharmacological effects include sedation, antiemetic properties, and the ability to reduce motion sickness. However, it may cause side effects such as drowsiness, dry mouth, and dizziness. Caution is advised when administering this medication, particularly in young children and the elderly, due to the potential for respiratory depression. Overall, promethazine hydrochloride is a versatile medication with a well-established profile in clinical use.
Formula:C17H21ClN2S
InChI:InChI=1/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H/p-1
InChI key:InChIKey=XXPDBLUZJRXNNZ-UHFFFAOYSA-N
SMILES:C(C(N(C)C)C)N1C=2C(SC=3C1=CC=CC3)=CC=CC2.Cl
Synonyms:
  • 10-[2-(Dimethylamino)propyl]phenothiazine hydrochloride
  • 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, hydrochloride (1:1)
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  • See more synonyms
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