CAS 60-87-7: (±)-Promethazine
Description:(±)-Promethazine is a first-generation antihistamine belonging to the phenothiazine class, primarily used for its antihistaminic, antiemetic, and sedative properties. It is characterized by its ability to block H1 histamine receptors, which helps alleviate allergic reactions and symptoms such as itching, runny nose, and sneezing. Additionally, (±)-Promethazine exhibits anticholinergic effects, contributing to its use in preventing motion sickness and as a preoperative sedative. The compound is typically administered in various forms, including tablets, syrups, and injections. Its chemical structure features a phenothiazine backbone, which is responsible for its pharmacological activity. The substance is known for its potential side effects, including drowsiness, dry mouth, and dizziness, and it should be used with caution in certain populations, such as the elderly or those with specific medical conditions. Due to its sedative effects, (±)-Promethazine is often prescribed for short-term management of sleep disturbances or anxiety. Overall, it is a versatile medication with a range of therapeutic applications, but it requires careful monitoring due to its side effect profile.
Formula:C17H20N2S
InChI:InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
InChI key:InChIKey=PWWVAXIEGOYWEE-UHFFFAOYSA-N
SMILES:S1C=2C=CC=CC2N(C=3C=CC=CC13)CC(N(C)C)C
- Synonyms:
- (.+-.)-Promethazine
- (2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
- 10-[2-(Dimethylamino)propyl]phenothiazine
- 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl- (9CI)
- Dimapp
- Diphergan
- N,N,α-Trimethyl-10H-phenothiazine-10-ethanamine
- Nsc 30321
- Phenothiazine, 10-[2-(dimethylamino)propyl]-
- Proazamine
- See more synonyms
- Procit
- Prometazin
- Prometazina
- Promethazin
- Protazine
- Prothazin
- Rp 3277
- Vallergine
- Promethaine
- 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-
- 10-(2-dimethylaminopropyl)phenothiazine
