CAS 608141-41-9

Apremilast

Description:

Apremilast is a small molecule drug primarily used in the treatment of autoimmune conditions such as psoriasis and psoriatic arthritis. It functions as a selective inhibitor of phosphodiesterase 4 (PDE4), an enzyme that plays a crucial role in the inflammatory response by degrading cyclic adenosine monophosphate (cAMP). By inhibiting PDE4, Apremilast increases intracellular cAMP levels, leading to a reduction in the production of pro-inflammatory cytokines and promoting anti-inflammatory mediators. The substance is characterized by its oral bioavailability and a relatively favorable pharmacokinetic profile, allowing for once-daily dosing. Apremilast is typically well-tolerated, though it may cause gastrointestinal side effects in some patients. Its chemical structure includes a pyrimidine core, contributing to its biological activity. As a therapeutic agent, Apremilast represents a targeted approach to managing chronic inflammatory diseases, offering an alternative to traditional systemic therapies.

Formula: C₂₂H₂₄N₂O₇S

InChI: InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1

InChI key: InChIKey=IMOZEMNVLZVGJZ-QGZVFWFLSA-N

SMILES: [C@H](CS(C)(=O)=O)(N1C(=O)C=2C(C1=O)=CC=CC2NC(C)=O)C3=CC(OCC)=C(OC)C=C3

Synonyms:

• (S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
• (S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
• Acetamide, N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
• Cc 10004
• N-[2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide
• N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
• Otezla
• Unii-up7qbp99pn
• Apremilast

Apremilast

CAS: 608141-41-9

Other aromatic organo-sulfur compounds (excluding pesticides)

Formula: C₂₂H₂₄N₂O₇S

Molecular weight: 460.13042

Ref: 45-1041850

N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide

CAS: 608141-41-9

Formula: C₂₂H₂₄N₂O₇S

Purity: 98%

Color and Shape: Solid

Molecular weight: 460.5002

Ref: IN-DA0039OD

Apremilast

CAS: 608141-41-9

Apremilast

Purity: ≥98%

Molecular weight: 460.5g/mol

Ref: 54-BUP17786

Apremilast

CAS: 608141-41-9

Apremilast

Purity: 98%

Molecular weight: 460.5g/mol

Ref: 54-OR1029550

Apremilast

CAS: 608141-41-9

Formula: C₂₂H₂₄N₂O₇S

Color and Shape: Pale Yellow Solid

Molecular weight: 460.50

Ref: 4Z-A-182001

Apremilast

CAS: 608141-41-9

Color and Shape: Neat

Ref: 86-MM3907.00

Apremilast

CAS: 608141-41-9

Formula: C₂₂H₂₄N₂O₇S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 460.50

Ref: 3B-A3669

Apremilast

CAS: 608141-41-9

Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.

Formula: C₂₂H₂₄N₂O₇S

Purity: 98.13% - 99.95%

Color and Shape: Solid

Molecular weight: 460.50

Ref: TM-T2923

Apremilast

CAS: 608141-41-9

Applications Apremilast is an oral phosphodiesterase 4 inhibitor used in the treatment of psoriatic arthritis.
References Gan, E., et al.: BioDrugs, 27, 359 (2013); Pathan, E., et al.: Annal. Rheum. DIs., 72, 1475 (2013);

Formula: C₂₂H₂₄N₂O₇S

Color and Shape: Neat

Molecular weight: 460.50

Ref: TR-A729700

Apremilast

CAS: 608141-41-9

Purity: 99%

Molecular weight: 460.5

Ref: 10-F862501

Apremilast

CAS: 608141-41-9

Apremilast is the commercial name of a phosphodiesterase4 (PDE4) inhibitor developed to treat chronic inflammatory disorders. Similarly to thalidomide, the apremilast molecule carries a phthalimide ring, but it lacks however the glutarimide ring needed to bind to cereblon, specifically targeted by thalidomide. As a drug, apremilast is indicated for the treatment of psoriasis and psoriatic arthritis.

Formula: C₂₂H₂₄N₂O₇S

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 460.5 g/mol

Ref: 3D-FA29510

Apremilast - Bio-X ™

CAS: 608141-41-9

Apremilast is the commercial name of a phosphodiesterase-4 (PDE4) inhibitor developed to treat chronic inflammatory disorders. Similarly to thalidomide, the apremilast molecule carries a phthalimide ring, but it lacks however the glutarimide ring needed to bind to cereblon, specifically targeted by thalidomide. As a drug, apremilast is indicated for the treatment of psoriasis and psoriatic arthritis.

Formula: C₂₂H₂₄N₂O₇S

Purity: Min. 99 Area-%

Color and Shape: White/Off-White Solid

Molecular weight: 460.5 g/mol

Ref: 3D-BA164215