CAS 61-75-6

bretylium tosylate

Description:

Bretylium tosylate is a quaternary ammonium compound primarily used as an antiarrhythmic agent in medical applications. It is characterized by its ability to block adrenergic receptors, which helps in the management of certain types of cardiac arrhythmias. The compound is typically presented as a white to off-white crystalline powder and is soluble in water and alcohol, making it suitable for intravenous administration. Bretylium tosylate acts by inhibiting the release of norepinephrine from sympathetic nerve endings, leading to a decrease in heart rate and myocardial contractility. Its pharmacological effects are particularly beneficial in emergency situations, such as ventricular fibrillation or tachycardia. However, it may also cause side effects, including hypotension and gastrointestinal disturbances. Due to its specific action on the cardiovascular system, bretylium tosylate is often used in conjunction with other antiarrhythmic medications to enhance therapeutic efficacy. As with all medications, its use should be carefully monitored by healthcare professionals to mitigate potential adverse effects.

Formula: C₁₁H₁₇BrN·C₇H₇O₃S

InChI: InChI=1S/C11H17BrN.C7H8O3S/c1-4-13(2,3)9-10-7-5-6-8-11(10)12;1-6-2-4-7(5-3-6)11(8,9)10/h5-8H,4,9H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1

InChI key: InChIKey=KVWNWTZZBKCOPM-UHFFFAOYSA-M

SMILES: S(=O)(=O)([O-])C1=CC=C(C)C=C1.C([N+](CC)(C)C)C1=C(Br)C=CC=C1

Synonyms:

• (2-Bromophenyl)Methyl-Ethyl-Dimethyl-Ammonium
• (o-Bromobenzyl)ethyldimethylammonium p-toluenesulfonate
• 2-Bromobenzylethyldimethylammonium Toluene-4-Sulphonate
• 4-Methylbenzenesulfonic Acid
• Ammonium, (o-bromobenzyl)ethyldimethyl-, p-toluenesulfonate
• Asl 603
• Benzenemethanaminium, 2-bromo-N-ethyl-N,N-dimethyl-, 4-methylbenzenesulfonate (1:1)
• Benzenemethanaminium, 2-bromo-N-ethyl-N,N-dimethyl-, salt with 4-methylbenzenesulfonic acid (1:1)
• Bretylan
• Bretylate
• Bretylium Tosilate
• Bretylium p-toluenesulfonate
• Bretylol
• Darenthin
• N-(2-bromobenzyl)-N,N-dimethylethanaminium 4-methylbenzenesulfonate
• N-(4-bromobenzyl)-N,N-dimethylethanaminium 4-methylbenzenesulfonate
• N-Ethyl-N-(o-bromobenzyl)-N,N-dimethylammonium tosylate
• NSC 62164
• Ornid

Bretylium Tosylate

CAS: 61-75-6

Formula: C₁₈H₂₄BrNO₃S

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 414.36

Ref: 3B-B6544

Bretylium Tosylate

CAS: 61-75-6

Quaternary ammonium salts and hydroxides, whether or not chemically defined, nesoi

Formula: C₁₈H₂₄BrNO₃S

Color and Shape: White Powder

Molecular weight: 413.06603

Ref: 45-1076352

Bretylium tosylate

CAS: 61-75-6

Bretylium tosylate

Formula: C₁₈H₂₄BrNO₃S

Purity: ≥98%

Molecular weight: 414.36

Ref: 54-BUP09809

Bretylium Tosylate

CAS: 61-75-6

Bretylium Tosylate

Formula: C₁₈H₂₄BrNO₃S

Purity: 99% (HPLC)

Molecular weight: 414.36

Ref: 54-OR1026293

Bretylium tosylate

CAS: 61-75-6

Formula: C₁₈H₂₄BrNO₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 414.3571

Ref: IN-DA00E8Y0

Bretylium tosylate

CAS: 61-75-6

N-(2-Bromobenzyl)-N,N-dimethylethanaminium 4-methylbenzenesulfonate

Formula: C₁₈H₂₄BrNO₃S

Purity: 99% (HPLC)

Molecular weight: 414.36

Ref: IN-DG118682

Bretylium tosylate

CAS: 61-75-6

Bretylium tosylate is an inhibitor of the presynaptic release of vasoconstrictor neurotransmitters, a available antiarrhythmic drug for ventricular arrhythmias.

Formula: C₁₈H₂₄BrNO₃S

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 414.357

Ref: TM-T7386

Bretylium tosylate

CAS: 61-75-6

Inhibitor of sodium/potassium ATP-ase; anti-arrhythmic

Formula: C₁₈H₂₄BrNO₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 414.36 g/mol

Ref: 3D-FB61550

BRETYLIUM TOSYLATE

CAS: 61-75-6

Purity: 99% (HPLC)

Molecular weight: 414.3599854

Ref: 10-F813341

Bretylium Tosylate

Controlled Product

CAS: 61-75-6

Applications Bretylium tosylate has a biphasic response, initially inducing norepinephrine release followed by sympathetic ganglionic blockade. Bretylium tosylate is a class III antiarrhythmic agent and a competitive inhibitor of acetylcholinesterase.
References Kuntzman, R., et al.: Clin. Pharmacol. Ther., 11, 829 (1970), Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Carter, J.E., et al.: Anal. Profiles Drug Subs., 9, 71 (1980),

Formula: C₁₁H₁₇BrN·C₇H₇O₃S

Color and Shape: Neat

Molecular weight: 414.36

Ref: TR-B677370

Bretylium tosilate

CAS: 61-75-6

Bretylium tosilate

Formula: C₁₈H₂₄BrNO₃S

Purity: 97.3%

Color and Shape: White To Off-White

Molecular weight: 413.06603

Ref: 47-612