CAS 6104-71-8

N-desmethylclozapine

Description:

N-desmethylclozapine, with the CAS number 6104-71-8, is a chemical compound that serves as a metabolite of clozapine, an atypical antipsychotic medication primarily used to treat schizophrenia. This compound is characterized by its structural modification, where a methyl group is removed from the clozapine molecule, resulting in altered pharmacological properties. N-desmethylclozapine exhibits affinity for various neurotransmitter receptors, including dopamine and serotonin receptors, which may contribute to its therapeutic effects and side effects. It is generally less potent than clozapine itself but can still influence the central nervous system. The compound is typically studied in the context of pharmacokinetics and pharmacodynamics, particularly regarding its role in the efficacy and safety profile of clozapine treatment. Additionally, understanding its characteristics is crucial for monitoring drug interactions and individual patient responses in clinical settings. As with many metabolites, the biological activity and safety profile of N-desmethylclozapine are important for optimizing therapeutic strategies in psychiatric care.

Formula: C₁₇H₁₇ClN₄

InChI: InChI=1/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19,21H,7-10H2

InChI key: InChIKey=JNNOSTQEZICQQP-UHFFFAOYSA-N

SMILES: ClC=1C=C2N=C(C=3C(NC2=CC1)=CC=CC3)N4CCNCC4

Synonyms:

• 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(1-piperazinyl)-
• 8-Chloro-11-(1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
• 8-chloro-11-(piperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine
• Acp 104
• Demethylclozapine
• Desmethylclozapine
• N-Demethylclozapine
• Norclozapine
• N-Desmethylclozapine
• N-Desmethylclozapine
• 8-Chloro-11-(piperazin-1-yl)-5H-dib
• 8-Chloro-11-piperazinyl-5H-dibenzo[b,e][1,4]diazepine, Norclozapine, Normethylclozapine
• Norclozapine (ACP-104)
• Clozapine EP IMpurity C
• N-Desmethyl Clozapine-d8 hydrochloride
• NORCLOZAPINE; DESMETHYLCLOZAPINE; NORMETHYLCLOZAPINE
• N-Desmethylclozapine solution
• Clozapine EP Impurity C
• Clozapine impurity 3/Clozapine EP Impurity C/Clozapine impurity A (USP)/8-chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
• 8-CHLORO-11-1[1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZEPINE
• Clozapine EP Impurity C Q: What is the storage condition of
• Clozapine Impurity 3(Clozapine EP Impurity C)
• Desmethylclozapine (Norclozapine)
• CLOZAPINE, NORMETHYL(NORMETHYLCLOZAPINE, NOR-CLOZAPINE, DESMETHYLC
• Clozapine EP Impurity C Q: What are the applications of
• Norclozapine Solution, 100ppm
• Clozapine EP Impurity C (N-Desmethyl Clozapine)
• Clozapine EP Impurity C Q: What is the CAS Number of
• 3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine
• Normethylclozapine
• 8-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
• Clozapine EP Impurity CQ: What is

Desmethylclozapine (Norclozapine) 1.0 mg/ml in Methanol

CAS: 6104-71-8

Color and Shape: Colourless

Ref: 61-AMP0480.03-01

Desmethylclozapine (Norclozapine)

CAS: 6104-71-8

Color and Shape: Neat

Ref: 61-FOR0480.03

Clozapine EP Impurity C

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄

Color and Shape: Yellow Solid

Molecular weight: 312.80

Ref: 4Z-C-1416

N-Desmethylclozapine

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄

Purity: ≥ 97.0%

Color and Shape: Yellow powder

Molecular weight: 312.80

Ref: 7W-GP9518

N-Desmethylclozapine

CAS: 6104-71-8

N-Desmethylclozapine

Purity: ≥95%

Molecular weight: 312.8g/mol

Ref: 54-BUP10018

N-Desmethylclozapine

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄

Purity: >95.0%(GC)

Color and Shape: White to Yellow powder to crystal

Molecular weight: 312.80

Ref: 3B-D5844

8-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine

Controlled Product

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄

Color and Shape: Neat

Molecular weight: 312.80

Ref: 86-MM0480.03

N-Desmethylclozapine

CAS: 6104-71-8

N-Desmethylclozapine: 5-HT2C antagonist (IC50: 7.1 nM), dopamine D4 antagonist, δ-opioid agonist.

Formula: C₁₇H₁₇ClN₄

Purity: 97.25% - 99.83%

Color and Shape: Yellow Crystalline Solid

Molecular weight: 312.8

Ref: TM-T5158

Clozapine EP Impurity C HCl Salt

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄·HCl

Color and Shape: Yellow Solid

Molecular weight: 312.80 36.46

Ref: 4Z-C-144

Clozapine EP Impurity C

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄

Molecular weight: 312.80

Ref: ST-EA-CP-C63003

N-Desmethyl Clozapine

Controlled Product

CAS: 6104-71-8

Applications N-Desmethyl Clozapine is a metabolite of Clozapine (C587500). N-Desmethyl Clozapine is a potent, allosteric agonist at human M1 receptors and is able to potentiate hippocampal NMDA receptor currents through M1 receptor activation.
References Sur, C., et al.: Proc. Nat. Acad. Sci. U. S. A., 100, 13674 (2003); Kuoppamaki, M. et al.: Eur. J. Pharm. Mol. Pharm. Sect., 245, 179 (1993); Olessen, O.V., et al.: J. Chromatog., 622, 39 (1993); Pirmohamed, M., et al.: J. Pharmacol. Exp. Ther., 272, 984 (1995)

Formula: C₁₇H₁₇ClN₄

Color and Shape: Light Yellow

Molecular weight: 312.80

Ref: TR-D292000

N-Desmethylclozapine

CAS: 6104-71-8

M01651 - N-Desmethylclozapine

Formula: C₁₇H₁₇ClN₄

Purity: >99%

Color and Shape: Solid

Molecular weight: 312.8

Ref: 10-M01651

N-Desmethyl clozapine

CAS: 6104-71-8

N-Desmethyl clozapine is a metabolite of the anti-psychotic drug clozapine. It has been shown to have similar effects to clozapine and can be used as an alternative treatment for chronic schizophrenia. The metabolite has been detected in human serum using a chromatographic method, which is an analytical technique that separates molecules based on their size and charge. N-Desmethyl clozapine was found to have a longer half-life than the parent compound, with a detection limit of 1 ng/mL in human serum. This metabolite also has been shown to inhibit fatty acid synthase activity and COX-1 activity in vitro, which may be responsible for its antipsychotic effects.

Formula: C₁₇H₁₇ClN₄

Purity: Min. 95%

Molecular weight: 312.8 g/mol

Ref: 3D-FD21255

N-DESMETHYLCLOZAPINE

CAS: 6104-71-8

Formula: C₁₇H₁₇ClN₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 312.7967

Ref: IN-DA00EB3S