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CAS 6104-71-8

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N-desmethylclozapine

Description:
N-desmethylclozapine, with the CAS number 6104-71-8, is a chemical compound that serves as a metabolite of clozapine, an atypical antipsychotic medication primarily used to treat schizophrenia. This compound is characterized by its structural modification, where a methyl group is removed from the clozapine molecule, resulting in altered pharmacological properties. N-desmethylclozapine exhibits affinity for various neurotransmitter receptors, including dopamine and serotonin receptors, which may contribute to its therapeutic effects and side effects. It is generally less potent than clozapine itself but can still influence the central nervous system. The compound is typically studied in the context of pharmacokinetics and pharmacodynamics, particularly regarding its role in the efficacy and safety profile of clozapine treatment. Additionally, understanding its characteristics is crucial for monitoring drug interactions and individual patient responses in clinical settings. As with many metabolites, the biological activity and safety profile of N-desmethylclozapine are important for optimizing therapeutic strategies in psychiatric care.
Formula:C17H17ClN4
InChI:InChI=1/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19,21H,7-10H2
InChI key:InChIKey=JNNOSTQEZICQQP-UHFFFAOYSA-N
SMILES:ClC=1C=C2N=C(C=3C(NC2=CC1)=CC=CC3)N4CCNCC4
Synonyms:
  • 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(1-piperazinyl)-
  • 8-Chloro-11-(1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
  • 8-chloro-11-(piperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine
  • Acp 104
  • Demethylclozapine
  • Desmethylclozapine
  • N-Demethylclozapine
  • Norclozapine
  • N-Desmethylclozapine
  • N-Desmethylclozapine
  • See more synonyms
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