CAS 6144-78-1

2-Pyridinecarboxamide,N-methyl-(9CI)

Description:

2-Pyridinecarboxamide, N-methyl- (CAS 6144-78-1) is an organic compound characterized by its pyridine ring structure, which is a six-membered aromatic ring containing one nitrogen atom. This compound features a carboxamide functional group, which is characterized by the presence of a carbonyl group (C=O) directly attached to a nitrogen atom (N). The N-methyl substitution indicates that one of the hydrogen atoms on the nitrogen is replaced by a methyl group (–CH3), enhancing its lipophilicity and potentially influencing its biological activity. 2-Pyridinecarboxamide derivatives are often studied for their pharmacological properties, including antimicrobial and anti-inflammatory activities. The compound is typically a solid at room temperature and may exhibit moderate solubility in polar solvents due to the presence of the amide group. Its chemical behavior is influenced by the electron-withdrawing nature of the pyridine nitrogen, which can affect reactivity in various chemical reactions. Overall, this compound is of interest in medicinal chemistry and related fields.

Formula: C₇H₈N₂O

InChI: InChI=1S/C7H8N2O/c1-8-7(10)6-4-2-3-5-9-6/h2-5H,1H3,(H,8,10)

InChI key: HXXAUIXTYRHFNO-UHFFFAOYSA-N

SMILES: CNC(=O)C1=CC=CC=N1

Synonyms:

• N-Methyl PicolinaMide
• N-Methylpicolinamide (Sorafenib Impurity)
• 2-Pyridinecarboxamide,N-methyl-(9CI)
• Sorafenib Related Compound 27
• N-Methyl-2-pyridinecarboxaMide
• 2-Pyridinecarboxamide, N-methyl-

N-Methylpicolinamide (Sorafenib Impurity)

CAS: 6144-78-1

N-Methylpicolinamide (Sorafenib Impurity)

Formula: C₇H₈N₂O

Purity: 97%

Molecular weight: 136.15

Ref: 54-OR1035618

Sorafenib Impurity 40 HCl

CAS: 6144-78-1

Formula: C₇H₈N₂O·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 136.15 36.46

Ref: 4Z-S-2747

Sorafenib impurity 4

CAS: 6144-78-1

Sorafenib impurity 4 is an impurity of Sorafenib.

Formula: C₇H₈N₂O

Molecular weight: 136.1512

Ref: TM-TYD-05049

N-methylpicolinamide

CAS: 6144-78-1

Formula: C₇H₈N₂O

Purity: 97%

Color and Shape: Liquid

Molecular weight: 136.1512

Ref: IN-DA00EF5M

N-METHYLPYRIDINE-2-CARBOXAMIDE

CAS: 6144-78-1

Purity: 97%

Color and Shape: Liquid (Oil)

Molecular weight: 136.154007

Ref: 10-F854533

N-Methyl Picolinamide

Controlled Product

CAS: 6144-78-1

Applications N-Substituted picolinamides as drowsiness-free central muscle relaxants.
References Takahashi, H., et al.: Bioorg. Med. Chem. Lett., 19, 5436 (2009),

Formula: C₇H₈N₂O

Color and Shape: Neat

Molecular weight: 136.15

Ref: TR-M326290

N-Methyl picolinamide

CAS: 6144-78-1

N-Methyl picolinamide is a novel anticancer agent that inhibits the activity of BCR-ABL kinase. It has been shown to be effective against human colon cancer cells (HCT116) and breast cancer cells (MCF-7). N-Methyl picolinamide binds to the ATP binding site of BCR-ABL kinase, inhibiting its enzymatic activity. The compound also binds to annexin II and blocks cell cycle progression at G2/M phase. The chemical structure of N-Methyl picolinamide includes an amide group, which may lead to low bioavailability. This drug has significant inhibitory activities against nitrogen atoms and inhibition constants for both the A and B forms of the enzyme.

Formula: C₇H₈N₂O

Purity: Min. 95%

Color and Shape: Colorless Powder

Molecular weight: 136.15 g/mol

Ref: 3D-FM25544

N-Methyl Picolinamide

CAS: 6144-78-1

Formula: C₇H₈N₂O

Molecular weight: 136.15

Ref: ST-EA-CP-S16026