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CAS 618385-01-6

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Vorapaxar

Description:
Vorapaxar is a synthetic small molecule that functions as a protease-activated receptor-1 (PAR-1) antagonist, primarily used in the prevention of thrombotic cardiovascular events. It selectively inhibits thrombin-induced platelet activation, thereby reducing the risk of blood clots. Vorapaxar is characterized by its high affinity for the PAR-1 receptor, which plays a crucial role in platelet aggregation and vascular biology. The compound is administered orally and has a long half-life, allowing for once-daily dosing. Vorapaxar is metabolized primarily by the liver, with cytochrome P450 enzymes playing a significant role in its biotransformation. Its pharmacokinetics can be influenced by factors such as age, liver function, and concomitant medications. While effective in reducing cardiovascular events, Vorapaxar is associated with an increased risk of bleeding, necessitating careful patient selection and monitoring. Overall, Vorapaxar represents a novel approach in antiplatelet therapy, particularly for patients with a history of myocardial infarction or peripheral artery disease.
Formula:C29H33FN2O4
InChI:InChI=1/C29H33FN2O4/c1-3-35-29(34)32-23-10-11-24-20(14-23)15-26-27(17(2)36-28(26)33)25(24)12-9-22-8-7-19(16-31-22)18-5-4-6-21(30)13-18/h4-9,12-13,16-17,20,23-27H,3,10-11,14-15H2,1-2H3,(H,32,34)/b12-9+/t17-,20+,23-,24-,25+,26-,27+/m1/s1
InChI key:InChIKey=ZBGXUVOIWDMMJE-QHNZEKIYSA-N
SMILES:C(=C/C1=CC=C(C=N1)C2=CC(F)=CC=C2)\[C@@H]3[C@]4([C@@](C[C@]5([C@]3(CC[C@@H](NC(OCC)=O)C5)[H])[H])(C(=O)O[C@@H]4C)[H])[H]
Synonyms:
  • Carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester
  • Carbamic acid, [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester
  • Ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]vinyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate
  • Sch 530348
  • Tra-Sch 530348
  • carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester
  • ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate
  • Vorapaxar
  • Voarapaxar
  • MK-5348
  • See more synonyms
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