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CAS 705260-08-8

:

Vorapaxar sulfate

Description:
Vorapaxar sulfate is a synthetic compound primarily used as an antiplatelet medication. It functions as a protease-activated receptor-1 (PAR-1) antagonist, inhibiting thrombin-induced platelet activation, which is crucial in preventing thrombotic cardiovascular events. The substance is characterized by its ability to selectively block the PAR-1 receptor, thereby reducing the risk of heart attacks and strokes in patients with a history of cardiovascular issues. Vorapaxar sulfate is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Its pharmacokinetics are influenced by factors such as liver metabolism and protein binding. Common side effects may include bleeding complications, which necessitate careful patient selection and monitoring. Vorapaxar sulfate is often used in conjunction with other antiplatelet therapies, enhancing its efficacy in managing cardiovascular diseases. As with any medication, it is essential to consider contraindications and potential drug interactions when prescribing Vorapaxar sulfate.
Formula:C29H33FN2O4·H2O4S
InChI:InChI=1S/C29H33FN2O4.H2O4S/c1-3-35-29(34)32-23-10-11-24-20(14-23)15-26-27(17(2)36-28(26)33)25(24)12-9-22-8-7-19(16-31-22)18-5-4-6-21(30)13-18;1-5(2,3)4/h4-9,12-13,16-17,20,23-27H,3,10-11,14-15H2,1-2H3,(H,32,34);(H2,1,2,3,4)/b12-9+;/t17-,20+,23-,24-,25+,26-,27+;/m1./s1
InChI key:InChIKey=NQRYCIGCIAWEIC-CKLVGUEFSA-N
SMILES:C(=C/C1=CC=C(C=N1)C2=CC(F)=CC=C2)\[C@@H]3[C@]4([C@@](C[C@]5([C@]3(CC[C@@H](NC(OCC)=O)C5)[H])[H])(C(=O)O[C@@H]4C)[H])[H].S(=O)(=O)(O)O
Synonyms:
  • Carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester, sulfate (1:1)
  • Carbamic acid, [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester, sulfate (1:1)
  • Sch 530348
  • Vorapaxar sulphate
  • Zontivity
  • Vorapaxar sulfate
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Found 11 products.