CAS 63-92-3

Phenoxybenzamine hydrochloride

Description:

Phenoxybenzamine hydrochloride is a non-selective alpha-adrenergic antagonist primarily used in the treatment of conditions such as pheochromocytoma, a type of tumor that can cause excessive catecholamine release. It is characterized by its ability to irreversibly bind to alpha-adrenergic receptors, leading to prolonged vasodilation and decreased blood pressure. The compound is typically administered orally and is known for its relatively long duration of action due to its irreversible binding mechanism. Phenoxybenzamine hydrochloride is a white to off-white crystalline powder, soluble in water and alcohol, and has a pH range that is generally neutral. Its pharmacological effects can include side effects such as orthostatic hypotension, tachycardia, and nasal congestion. Due to its mechanism of action, it is important to monitor patients closely for cardiovascular responses. As with any medication, it should be used under the guidance of a healthcare professional, considering potential interactions and contraindications.

Formula: C₁₈H₂₂ClNO·ClH

InChI: InChI=1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H

InChI key: InChIKey=VBCPVIWPDJVHAN-UHFFFAOYSA-N

SMILES: C(N(C(COC1=CC=CC=C1)C)CCCl)C2=CC=CC=C2.Cl

Synonyms:

• 2-(N-benzyl-2-chloroethylamino)-1-phenoxypropane hydrochloride
• Bensylyt Nen
• Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride
• Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride (1:1)
• Benzyl(2-Chloroethyl)(1-Methyl-2-Phenoxyethyl)Amine Hydrochloride
• Benzylamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride
• Dibenzylin
• Dibenzyline chloride
• Dibenzyline hydrochloride
• Dibenzyran
• Fenoxybenzamin
• N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine hydrochloride
• N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride
• N-2-Phenoxyisopropyl-N-benzyl-β-chloroethylamine hydrochloride
• N-2-phenoxyisopropyl-N-benzyl-chloroethylamine hydrochloride
• N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-aminium
• N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-aminium chloride
• N-phenoxyisopropyl-N-benzyl-beta-chloroethylamine hydrochloride
• NSC 37448
• Phenoxybenzamide Hydrochloride
• Phenoxybenzamide, HCl
• Phenoxybenzamine HCL

Phenoxybenzamine Hydrochloride

CAS: 63-92-3

Formula: C₁₈H₂₂ClNO·HCl

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 340.29

Ref: 3B-D0158

Phenoxybenzamine hydrochloride

CAS: 63-92-3

Selective alpha adrenergic blocking agent. Irreversible calmodulin inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or

Formula: C₁₈H₂₃Cl₂NO

Color and Shape: White to off-white, Powder

Molecular weight: 340.29

Ref: 02-J61900

Phenoxybenzamine Hydrochloride

CAS: 63-92-3

Color and Shape: Neat

Ref: 61-FOR0778.00

Phenoxybenzamine hydrochloride

CAS: 63-92-3

Phenoxybenzamine hydrochloride

Formula: C₁₈H₂₂CINOHCl

Purity: 97.0%

Color and Shape: White

Molecular weight: 443.05129

Ref: 47-1072

PHENOXYBENZAMINE HYDROCHLORIDE CRS

CAS: 63-92-3

PHENOXYBENZAMINE HYDROCHLORIDE CRS

Ref: 41-Y0002282

Phenoxybenzamine Hydrochloride

CAS: 63-92-3

Aromatic drugs of amino-alcohols, other than those contg > one kind of oxygen function, their ethers and esters; salts thereof, nesoi

Formula: C₁₈H₂₂ClNO·HCI

Color and Shape: White Off-White Powder

Molecular weight: 443.05129

Ref: 45-1526007

Phenoxybenzamine hydrochloride

CAS: 63-92-3

Phenoxybenzamine hydrochloride: non-selective, irreversible alpha-blocker; antihypertensive, vasodilator, may cause tachycardia, potential carcinogen.

Formula: C₁₈H₂₃Cl₂NO

Purity: 98.04% - >99.99%

Color and Shape: Antihypertensive Drug

Molecular weight: 340.3

Ref: TM-T1158

Phenoxybenzamine hydrochloride

CAS: 63-92-3

Formula: C₁₈H₂₂ClNO·HCl

Molecular weight: 340.29

Ref: 7W-GL1636

Phenoxybenzamine HCl

CAS: 63-92-3

Formula: C₁₈H₂₂ClNO·HCl

Molecular weight: 303.83 36.46

Ref: 4Z-P-0812

Phenoxybenzamine HCl

CAS: 63-92-3

Phenoxybenzamine HCl

Purity: 98%

Molecular weight: 340.30g/mol

Ref: 54-OR1014632

Phenoxybenzamine hydrochloride

CAS: 63-92-3

Phenoxybenzamine hydrochloride

Purity: ≥98%

Molecular weight: 340.3g/mol

Ref: 54-BUP18326

Phenoxybenzamine Hydrochloride

CAS: 63-92-3

Formula: C₁₈H₂₂ClNO·ClH

Color and Shape: Neat

Molecular weight: 340.29

Ref: 86-MM0778.00

Phenoxybenzamine hydrochloride

CAS: 63-92-3

Phenoxybenzamine hydrochloride is a drug with pharmacological properties, which is used in the treatment of carcinoid syndrome. It is a combination therapy group that can be used to treat patients with neurological disorders. Phenoxybenzamine inhibits the activity of the 5-HT2 receptors and has been shown to reduce neuronal death. In addition, it has been shown to increase chemiluminescence in cells infected with HIV. Phenoxybenzamine also has effects on cardiac function and can be used to treat congestive heart failure as well as high levels of natriuretic peptides in maternal blood during pregnancy. It has also been shown to be effective against infectious diseases, such as tuberculosis and malaria.

Formula: C₁₈H₂₃Cl₂NO

Purity: Min. 90 Area-%

Color and Shape: Powder

Molecular weight: 340.29 g/mol

Ref: 3D-FP26891

Phenoxybenzamine.HCl

CAS: 63-92-3

M02323 - Phenoxybenzamine.HCl

Formula: C₁₈H₂₃Cl₂NO

Purity: 98%+(HPLC);RG

Color and Shape: Solid

Molecular weight: 340.29

Ref: 10-M02323

Phenoxybenzamine Hydrochloride

Controlled Product

CAS: 63-92-3

Applications An irreversible α-antagonist. Used in the treatment of hypertension, it has a relatively slow onset and prolonged effect when compared to alternative α-blockers.
References Glass, B., et al.: J. Pharm. Pharm. Sci., 9, 398 (2006), Huang, R., et al.: Chem. Res. Toxicol., 21, 659 (2008), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),

Formula: C₁₈H₂₂ClNO·ClH

Color and Shape: Neat

Molecular weight: 340.29

Ref: TR-P227990