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CAS 63-92-3

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Phenoxybenzamine hydrochloride

Description:
Phenoxybenzamine hydrochloride is a non-selective alpha-adrenergic antagonist primarily used in the treatment of conditions such as pheochromocytoma, a type of tumor that can cause excessive catecholamine release. It is characterized by its ability to irreversibly bind to alpha-adrenergic receptors, leading to prolonged vasodilation and decreased blood pressure. The compound is typically administered orally and is known for its relatively long duration of action due to its irreversible binding mechanism. Phenoxybenzamine hydrochloride is a white to off-white crystalline powder, soluble in water and alcohol, and has a pH range that is generally neutral. Its pharmacological effects can include side effects such as orthostatic hypotension, tachycardia, and nasal congestion. Due to its mechanism of action, it is important to monitor patients closely for cardiovascular responses. As with any medication, it should be used under the guidance of a healthcare professional, considering potential interactions and contraindications.
Formula:C18H22ClNO·ClH
InChI:InChI=1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H
InChI key:InChIKey=VBCPVIWPDJVHAN-UHFFFAOYSA-N
SMILES:C(N(C(COC1=CC=CC=C1)C)CCCl)C2=CC=CC=C2.Cl
Synonyms:
  • 2-(N-benzyl-2-chloroethylamino)-1-phenoxypropane hydrochloride
  • Bensylyt Nen
  • Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride
  • Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride (1:1)
  • Benzyl(2-Chloroethyl)(1-Methyl-2-Phenoxyethyl)Amine Hydrochloride
  • Benzylamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride
  • Dibenzylin
  • Dibenzyline chloride
  • Dibenzyline hydrochloride
  • Dibenzyran
  • See more synonyms
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