CAS 638-94-8

Desonide

Description:

Desonide is a synthetic corticosteroid primarily used for its anti-inflammatory and immunosuppressive properties in dermatological applications. It is characterized by its relatively low potency compared to other corticosteroids, making it suitable for treating mild to moderate skin conditions such as eczema, dermatitis, and psoriasis. Desonide is typically formulated in topical preparations, including creams, ointments, and lotions, allowing for localized treatment with minimal systemic absorption. The chemical structure of desonide includes a steroid nucleus, which is essential for its biological activity, and it exhibits a favorable safety profile, particularly for use in sensitive areas of the skin. Its mechanism of action involves the inhibition of inflammatory mediators, thereby reducing redness, swelling, and itching. As with all corticosteroids, prolonged use may lead to potential side effects, including skin thinning and tolerance, so it is recommended to use desonide under the guidance of a healthcare professional. Overall, desonide serves as an effective option for managing various inflammatory skin disorders while minimizing the risk of adverse effects associated with more potent corticosteroids.

Formula: C₂₄H₃₂O₆

InChI: InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1

InChI key: InChIKey=WBGKWQHBNHJJPZ-LECWWXJVSA-N

SMILES: C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)(C)O2)[H])([C@]4([C@]([C@@H](O)C3)([C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H])[H]

Synonyms:

• (11β,16α)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
• 11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide
• 11β,21-Dihydroxy-16α,17α-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
• 16α,17α-(Isopropylidenedioxy)prednisolone
• 16α-Hydroxyprednisolone 16,17-acetonide
• 16α-Hydroxyprednisolone 16α,17α-acetonide
• 16α-Hydroxyprednisolone acetonide
• 2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregna-1,4-diene-3,20-dione deriv.
• Apolar
• Budesonide acetonide
• D 2083
• Desonid
• Desonida
• Desowen
• Locapred
• Prednacinolone
• Prednacinolone acetonide
• Prednisolone acetonide
• Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α)-
• Pregna-1,4-diene-3,20-dione, 11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
• Prenacid
• Sterax
• Steroderm
• Topifug
• Tridesilon

Desonide

CAS: 638-94-8

Adrenal cortical hormones and their derivatives nesoi

Formula: C₂₄H₃₂O₆

Color and Shape: White Off-White Powder

Molecular weight: 416.21989

Ref: 45-1173304

Desonide

CAS: 638-94-8

Desonide is a synthetic topical steroid that reduces inflammation by inhibiting key inflammatory mediators.

Formula: C₂₄H₃₂O₆

Purity: 99.5% - 99.74%

Color and Shape: Solid

Molecular weight: 416.51

Ref: TM-T1168

(1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one

CAS: 638-94-8

Formula: C₂₄H₃₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 416.5073

Ref: IN-DA003AX4

Desonide

CAS: 638-94-8

Formula: C₂₄H₃₂O₆

Molecular weight: 416.51

Ref: 7W-GP4906

Desonide

CAS: 638-94-8

Desonide

Purity: 98%

Molecular weight: 416.51g/mol

Ref: 54-OR1030351

Desonide

CAS: 638-94-8

Desonide

Purity: ≥98%

Molecular weight: 416.51g/mol

Ref: 54-BUP17870

Desonide (Budesonide EP Impurity F)

CAS: 638-94-8

Formula: C₂₄H₃₂O₆

Color and Shape: White To Off-White Solid

Molecular weight: 416.51

Ref: 4Z-D-411

Desonide

CAS: 638-94-8

Formula: C₂₄H₃₂O₆

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 416.51

Ref: 3B-D5578

16α,17-[1-Methylethylidenebis(oxy)]-11β,21-dihydroxypregna-1,4-diene-3,20-dione (Desonide)

CAS: 638-94-8

Color and Shape: White

Ref: 86-MM0204.06

Desonide-d6 (Budesonide EP Impurity F-d6)

CAS: 638-94-8

Formula: C₂₄H₂₆D₆O₆

Molecular weight: 422.55

Ref: 4Z-D-4123

Desonide-13C3

Controlled Product

CAS: 638-94-8

Applications Anti-inflammatory.
References Phillips, et al.: Toxicol. Appl. Pharmacol., 20, 522 (1971), Sanen, F.J., et al.: Int. J. Clin. Pharmacol. Biopharm., 12, 174 (1975), Tarayre, J.P., et al.: Pharmacol., 19, 323 (1979).

Formula: C₂₁₁₃C₃H₃₂O₆

Color and Shape: Neat

Molecular weight: 419.49

Ref: TR-D296942

Desonide

CAS: 638-94-8

Purity: 98%

Molecular weight: 416.5140075683594

Ref: 10-F787579

Budesonide EP Impurity F

CAS: 638-94-8

Formula: C₂₄H₃₂O₆

Molecular weight: 416.51

Ref: ST-EA-CP-B19006

Desonide

Controlled Product

CAS: 638-94-8

Impurity Budesonide EP Impurity F
Applications Desonide(Budesonide EP Impurity F) is an impurity of Budesonide (B689490), an anti-inflammatory.
References Phillips, et al.: Toxicol. Appl. Pharmacol., 20, 522 (1971), Sanen, F.J., et al.: Int. J. Clin. Pharmacol. Biopharm., 12, 174 (1975), Tarayre, J.P., et al.: Pharmacol., 19, 323 (1979).

Formula: C₂₄H₃₂O₆

Color and Shape: White

Molecular weight: 416.51

Ref: TR-D296940

Desonide

CAS: 638-94-8

Desonide is a synthetic, low-potency corticosteroid with antiinflammatory activity. It is chemically stable and has only minimal potential for skin irritation. The pharmacokinetics of desonide have been studied in humans and rats. Desonide is metabolized to betamethasone, its active form, which binds to glucocorticoid receptors in the nucleus of cells. This binding inhibits the transcription of genes that regulate inflammatory responses, leading to relief from symptoms such as redness, swelling, and itching. Desonide has shown efficacy in the treatment of alopecia areata (hair loss) with topical application.

Formula: C₂₄H₃₂O₆

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 416.51 g/mol

Ref: 3D-FD21374

21-Carboxy-20-hydroxy-Desonide

Controlled Product

CAS: 638-94-8

Applications 21-Carboxy-20-hydroxy-Desonide is an impurity in the synthesis of Desonide (D296940), an anti-inflammatory.
References Phillips, et al.: Toxicol. Appl. Pharmacol., 20, 522 (1971), Sanen, F.J., et al.: Int. J. Clin. Pharmacol. Biopharm., 12, 174 (1975), Tarayre, J.P., et al.: Pharmacol., 19, 323 (1979).

Formula: C₂₄H₃₂O₇

Color and Shape: Neat

Molecular weight: 432.507

Ref: TR-C178495