CAS 63968-75-2

4-chloro-N-(2-methyl-1H-indol-1-yl)-3-sulfamoylbenzamide

Description:

4-Chloro-N-(2-methyl-1H-indol-1-yl)-3-sulfamoylbenzamide, with the CAS number 63968-75-2, is a chemical compound characterized by its complex structure, which includes a chloro group, an indole moiety, and a sulfonamide functional group. This compound typically exhibits properties associated with sulfonamides, such as potential antibacterial activity, due to the presence of the sulfonamide group. The indole structure contributes to its biological activity, often influencing interactions with biological targets. The chloro substituent can enhance lipophilicity, potentially affecting the compound's solubility and permeability. In terms of physical properties, it may be a solid at room temperature, with specific melting and boiling points dependent on its molecular interactions. The compound's reactivity can be influenced by the functional groups present, making it a candidate for various chemical reactions, including nucleophilic substitutions and coupling reactions. Overall, this compound's unique structure suggests potential applications in medicinal chemistry and drug development, particularly in targeting specific biological pathways.

Formula: C₁₆H₁₄ClN₃O₃S

InChI: InChI=1/C16H14ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-9H,1H3,(H,19,21)(H2,18,22,23)

SMILES: Cc1cc2ccccc2n1N=C(c1ccc(c(c1)S(=O)(=O)N)Cl)O

Indapamide impurity B

CAS: 63968-75-2

Indapamide impurity B

Color and Shape: Beige

Ref: 47-1000

INDAPAMIDE IMPURITY B CRS

CAS: 63968-75-2

INDAPAMIDE IMPURITY B CRS

Ref: 41-I0150020

Indapamide Related Compound A (4-chloro-N-(2-methyl-1H-indol-1-yl)-3-sulfamoylbenzamide)

CAS: 63968-75-2

Sulfonamides, nesoi

Formula: C₁₆H₁₄ClN₃O₃S

Color and Shape: Yellow Brown Powder

Molecular weight: 363.04444

Ref: 45-1338812

Dehydroindapamide

CAS: 63968-75-2

Dehydroindapamide

Formula: C₁₆H₁₄ClN₃O₃S

Purity: ≥98%

Molecular weight: 363.82

Ref: 54-BUP23745

INDAPAMIDE RELATED COMPOUND A (50 MG) (4-CHLORO-N-(2-METHYL-INDOL-1-YL)-3-SULFAMOYLBEN-ZAMIDE) (AS)

CAS: 63968-75-2

Formula: C₁₆H₁₄ClN₃O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 363.8187

Ref: IN-DA00EFCL

Indapamide EP Impurity B (Indapamide USP Related Compound A, Dehydro Indapamide)

CAS: 63968-75-2

Formula: C₁₆H₁₄ClN₃O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 363.83

Ref: 4Z-I-136

Indapamide

Controlled Product

CAS: 26807-65-8, 63968-75-2

Formula: C₁₆H₁₄ClN₃O₃S

Color and Shape: White To Off-White

Molecular weight: 363.82

Ref: 86-MM0477.00

4-Chloro-N-(2-methyl-1H-indol-1-yl)-3-sulphamoylbenzamide

Controlled Product

CAS: 63968-75-2

Formula: C₁₆H₁₄ClN₃O₃S

Color and Shape: White To Light Brown

Molecular weight: 363.82

Ref: 86-MM0477.02

Indapamide EP Impurity B

CAS: 63968-75-2

Formula: C₁₆H₁₄ClN₃O₃S

Molecular weight: 363.82

Ref: ST-EA-CP-I21002

Dehydro Indapamide

Controlled Product

CAS: 63968-75-2

Impurity Indapamide USP Related Compound A/ Indapamide EP Impurity B
Applications A metabolite of Indapamide (M5). A dehydrogenation pathway by cytochromes P450. Indapamide USP Related Compound A
References Tamura A., et al.: Chem. Pharm. Bull., 38, 225 (1990), Harlow, G.R., et al.: J. Biol. Chem., 272, 5396 (1997), Ozden, T., et al.: Pharm. Pharmacol. Commun., 4, 397 (1998), Gruciani, G., et al.: J. Med. Chem., 48, 6970 (2005), Sun, H., et al.: Drug. Metab. Dispos., 37, 672 (2009),

Formula: C₁₆H₁₄ClN₃O₃S

Color and Shape: Neat

Molecular weight: 363.82

Ref: TR-D229660

Dehydroindapamide

CAS: 63968-75-2

Dehydroindapamide is the indole form of Indapamide that serves as a quantitative analytical standard for measuring Indapamide turnover by CYP3A4, demonstrating approximately tenfold higher metabolic turnover than Indoline and slightly enhanced CYP3A4 affinity, thereby supporting detailed studies of drug metabolism, enzyme kinetics, and pharmacokinetic profiling.

Formula: C₁₆H₁₄ClN₃O₃S

Purity: 99.65%

Color and Shape: White Solid

Molecular weight: 363.82

Ref: TM-T200811

Dehydro indapamide

CAS: 63968-75-2

Dehydro indapamide is a drug that belongs to the class of antihypertensive agents. It is a prodrug that is metabolized in vivo to indapamide and hydrochlorothiazide. Dehydro indapamide has been shown to be efficacious in the treatment of hypertension, and it has a pharmacokinetic profile similar to other diuretics. The clinical data for this drug are limited, but there have been no serious side effects reported with its use.

Formula: C₁₆H₁₄ClN₃O₃S

Purity: Min. 95%

Molecular weight: 363.82 g/mol

Ref: 3D-FD20918