CAS 64224-21-1

Oltipraz

Description:

Oltipraz is a synthetic compound classified as a dithiolethione, primarily known for its potential chemopreventive properties. It is characterized by its unique chemical structure, which includes a dithiolethione moiety that contributes to its biological activity. Oltipraz has been studied for its ability to induce phase II detoxifying enzymes, thereby enhancing the body's defense against carcinogens. It is also recognized for its antioxidant properties, which may help in reducing oxidative stress. The compound has shown promise in various preclinical and clinical studies, particularly in the context of liver health and cancer prevention. Oltipraz is typically administered orally and has been evaluated for its safety and efficacy in different populations. Its pharmacokinetics involve absorption, metabolism, and excretion, which are essential for understanding its therapeutic potential. Overall, Oltipraz represents a significant area of interest in medicinal chemistry and cancer research, with ongoing studies aimed at elucidating its mechanisms of action and potential applications in clinical settings.

Formula: C₈H₆N₂S₃

InChI: InChI=1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3

InChI key: InChIKey=CKNAQFVBEHDJQV-UHFFFAOYSA-N

SMILES: CC1=C(SSC1=S)C=2C=NC=CN2

Synonyms:

• 3H-1,2-Dithiole-3-thione, 4-methyl-5-(2-pyrazinyl)-
• 3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-
• 4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione
• 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione
• 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione
• 5-(2-Pyrazinyl)-4-methyl-1,2-dithiole-3-thione
• Brn 0978110
• Ccris 4048
• Nsc 347901
• Oltipraz [INN]
• Oltiprazum
• Oltiprazum [INN-Latin]
• Rp 35972
• Unii-6N510Jul1Y

Oltipraz

CAS: 64224-21-1

Formula: C₈H₆N₂S₃

Purity: >98.0%(GC)

Color and Shape: Red to Dark red powder to crystal

Molecular weight: 226.33

Ref: 3B-O0611

4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione

CAS: 64224-21-1

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₈H₆N₂S₃

Color and Shape: Red, Powder

Molecular weight: 226.33

Ref: 02-H35120

3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-

CAS: 64224-21-1

Formula: C₈H₆N₂S₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 226.3416

Ref: IN-DA00IBC6

Oltipraz

CAS: 64224-21-1

Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.

Formula: C₈H₆N₂S₃

Purity: 98.79% - 99.77%

Color and Shape: Solid

Molecular weight: 226.34

Ref: TM-T0153

Oltipraz

CAS: 64224-21-1

Oltipraz

Purity: ≥95%

Molecular weight: 226.34g/mol

Ref: 54-BUP15094

4-Methyl-5-(Pyrazin-2-Yl)-3H-1,2-Dithiole-3-Thione

CAS: 64224-21-1

4-Methyl-5-(Pyrazin-2-Yl)-3H-1,2-Dithiole-3-Thione

Purity: 99%

Molecular weight: 226.34g/mol

Ref: 54-OR1011612

Oltipraz

CAS: 64224-21-1

Formula: C₈H₆N₂S₃

Molecular weight: 226.34

Ref: 7W-GL2501

4-Methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione

CAS: 64224-21-1

Formula: C₈H₆N₂S₃

Purity: ≥98%

Molecular weight: 226.33

Ref: 10-F457229

Oltipraz

CAS: 64224-21-1

Applications Oltipraz is a synthetic, substituted 1,2-dithiole-3-thione previously used in humans as an antischistosomal agent. Animal studies have demonstrated that oltipraz is a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Oltipraz is now known to be used for tumor prevention purposes.
References Yu, Z., et al.: Diabetologia., 54, 922 (2011); Benson, A.B., et al.: J. Cell. Biochem. Suppl., 17, 278 (1993);

Formula: C₈H₆N₂S₃

Color and Shape: Red Solid

Molecular weight: 226.34

Ref: TR-O586050

Oltipraz-d3

CAS: 64224-21-1

Oltipraz-d3 is a chemopreventive agent that has been shown to inhibit the production of reactive oxygen species and inflammatory cytokines. Oltipraz-d3 inhibits the activation of the nuclear factor kappa B (NF-κB) pathway by preventing phosphorylation and degradation of IkappaBα, which is an inhibitor of NF-κB. It also reduces oxidative stress in the cell by increasing glutathione levels. Oltipraz-d3 has been shown to reduce DNA damage in human cells exposed to aflatoxin and may be useful for treating chronic liver diseases, such as cancer or injury.

Formula: C₈H₃D₃N₂S₃

Purity: Min. 95%

Molecular weight: 229.36 g/mol

Ref: 3D-PCA22421